Effect of torsion on microvenous anastomotic patency in rat model and early thrombolytic phenomenon

Selvaggi, Gennaro; Salgarello, Marzia; Farallo, Eugenio Giuseppe; Anicic, Sylvia; Formaggia, Luca

doi:10.1002/micr.20085

Cited by 12 publications

(12 citation statements)

References 4 publications

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“…[5][6][7] The physiopathological reason of the reduction of the patency rate should be searched in the different blood flow after twisting of the anastomosis, which is, in the experi- Figure 3. Experimental torsion of a steel cylinder where an exceeding critical value has been applied: the original cylindrical shape suddenly changes, and a wave pattern appears on the cylinder surface, which is now highly deformed.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] The interpretation of all the factors involved in the torsion of the microvessel, in its final shape and in the patency rates following different angles of torsion, induced investigators 7 to open a discussion. Topalan et al 6 stated in relation to the arteries that ''the torsional effect of the vessel was distributed to the weakest point of the segment, where its branches exit both proximally and distally,'' and that ''this distribution seems to be homogeneous along the branches.''…”

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Mathematical explanation of the buckling of the vessels after twisting of the microanastomosis

2006

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Mathematical explanation of the buckling of the vessels after twisting of the microanastomosis

2006

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“…Arteries also often experience axial twisting due to body movement or surgical procedures (Barton and Margolis 1975; Pao et al 1992; Han et al 1998; Norris et al 2000; Dobrin et al 2001; Ding et al 2002; Selvaggi et al 2004). Mobile arteries within the torso and lower extremities such as the iliac, superficial femoral, and femoropopliteal are subjected to torsion with hip and knee flexion (Cheng et al 2006; Choi et al 2009; Klein et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Severe twisting of arteries and veins can affect their patency, impair endothelium function and delay wound healing in the anastomosis area, and lead to distal ischemia (Barton and Margolis 1975; Endean et al 1989; Izquierdo et al 1998; Topalan et al 2003; Selvaggi et al 2004; Garcia et al 2017). These changes can cause increased risks for thrombosis and organ dysfunction (Endean et al 1989; Bilgin et al 2003; Selvaggi et al 2004; Chesnutt and Han 2011).…”

Section: Introductionmentioning

confidence: 99%

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Arterial wall remodeling under sustained axial twisting in rats

Wang

Yang

et al. 2017

Journal of Biomechanics

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Blood vessels often experience torsion along their axes and it is essential to understand their biological responses and wall remodeling under torsion. To this end, a rat model was developed to investigate the arterial wall remodeling under sustained axial twisting in vivo. Rat carotid arteries were twisted at 180 degrees along the longitudinal axis through a surgical procedure and maintained for different durations up to 4 weeks. The wall remodeling in these twisted arteries was examined using histology, immunohistochemistry and fluorescent microscopy. Our data showed that arteries remodeled under twisting in a time-dependent manner during the 4 weeks post-surgery. Cell proliferation, MMP-2 and MMP-9 expressions, medial wall thickness and lumen diameter increased while collagen to elastin ratio decreased. While the size and number of internal elastic lamina fenestrae increased with elongated shapes, the endothelial cells elongated and aligned towards the blood flow direction gradually. These results demonstrated that sustained axial twisting results in artery remodeling in vivo. The rat carotid artery twisting model is an effective in vivo model for studying arterial wall remodeling under long-term torsion. These results enrich our understanding of vascular biology and arterial wall remodeling under mechanical stresses.

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Twist buckling behavior of arteries

Garcia

Lamm

Han

2012

Biomech Model Mechanobiol

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Arteries are often subjected to torsion due to body movement and surgical procedures. While it is essential that arteries remain stable and patent under twisting loads, the stability of arteries under torsion is poorly understood. The goal of this work was to experimentally investigate the buckling behavior of arteries under torsion and to determine the critical buckling torque, the critical buckling twist angle, and the buckling shape. Porcine common carotid arteries were slowly twisted in vitro until buckling occurred while subjected to a constant axial stretch ratio (1.1, 1.3, 1.5 (in vivo level), and 1.7) and lumen pressure (20, 40, 70, and 100 mmHg). Upon buckling, the arteries snapped to form a kink. For a group of six arteries, the axial stretch ratio significantly affected the critical buckling torque (p < 0.002) and the critical buckling twist angle (p < 0.001). Lumen pressure also significantly affected the critical buckling torque (p < 0.001) but had no significant effect on the critical twist angle (p = 0.067). Convex material constants for a Fung strain energy function were determined and fit well with the axial force, lumen pressure, and torque data measured pre-buckling. The material constants are valid for axial stretch ratios, lumen pressures, and rotation angles of 1.3 – 1.5, 20 – 100 mmHg, and 0 – 270 degrees, respectively. The current study elucidates the buckling behavior of arteries under torsion and provides new insight into mechanical instability of blood vessels.

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Effect of torsion on microvenous anastomotic patency in rat model and early thrombolytic phenomenon

Cited by 12 publications

References 4 publications

Mathematical explanation of the buckling of the vessels after twisting of the microanastomosis

Mathematical explanation of the buckling of the vessels after twisting of the microanastomosis

Arterial wall remodeling under sustained axial twisting in rats

Twist buckling behavior of arteries

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