Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study

Abstract

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Effects of anesthesia on long-term survival in cancer surgery: A systematic review and meta-analysis

“…Forty-two retrospective cohort studies and two RCTs with a total of 686,923 patients were included in this study [ [19] , [20] , [21] , [22] , [23] , [24] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] ]. Thirty-five trials were single-center studies [ 19 , [21] , [22] , [23] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [50] , [51] , …”

“…Types of cancer surgery and inhalation anesthetics varied between studies. In total, two studies enrolled participants undergoing surgery for glioblastoma [ 47 , 56 ], one study for oral cancer [ 63 ], nine studies for breast cancer [ 34 , 37 , 42 , 45 , 49 , 53 , 59 , 61 , 71 ], five studies for non-small cell lung cancer [ 38 , 55 , 60 , 65 , 69 ], two studies for esophageal cancer [ 36 , 68 ], four studies for gastric cancer [ 40 , 44 , 50 , 57 ], five studies for colorectal cancer [ 34 , 39 , 48 , 54 , 62 ], four studies for hepatobiliary cancer [ 19 , 41 , 43 , 51 ], two studies for pancreatic cancer [ 52 , 64 ], two studies for gynecological cancer [ 21 , 22 ], two studies for urological cancer [ 23 , 58 ], one study for osteosarcoma [ 66 ], and six studies for various cancers [ 20 , 24 , 35 , 46 , 68 , 70 ]. For inhalation anesthetics, seventeen studies used sevoflurane to maintain anesthesia [ 19 , 21 , 34 , 38 , 40 , [47] , [48] , [49] , 53 , 59 , [62] , [63] , [64] , …”

“…For inhalation anesthetics, seventeen studies used sevoflurane to maintain anesthesia [ 19 , 21 , 34 , 38 , 40 , [47] , [48] , [49] , 53 , 59 , [62] , [63] , [64] , [65] , 67 , 70 , 71 ], nine studies used desflurane [ 22 , 39 , [41] , [42] , [43] , 50 , 52 , 56 , 66 ] and eighteen studies administered various inhalation anesthetics [ 20 , 23 , 24 , [35] , [36] , [37] , [44] , [45] , [46] , 51 , 54 , 55 , 57 , 58 , 60 , 61 , 68 , 69 ]. Twenty-six studies included elective surgery [ 19 , 21 , 22 , 36 , [38] , [39] , [40] , [41] , 43 , 44 , [46] , [47] , [48] , [50] , [51] , [52] , [53] , 56 , 60 , [62] , [63] , …”

Comment on "Effect of total intravenous versus inhalation anesthesia on long-term oncological outcomes in patients undergoing curative resection for early-stage non-small cell lung cancer: a retrospective cohort study"

“…the total intravenous anesthesia group compared to the inhalational anesthesia group, analyzing the retrospective data of 1,508 non-small cell lung cancer (NSCLC) patients undergoing curative resection [1]. While the authors are commended for the research endeavors, their findings necessitate careful interpretation considering the following observations.…”

“…Moreover, the CONUT score continued to predict poor OS in the subgroup analysis regardless of the surgical or non-surgical treatment modality. The fact that 9 out of 11 studies in the Peng et al meta-analysis employed surgical resection as the central treatment modality, is worthwhile to elucidate here given Seo et al study was limited to the patients undergoing curative resection [1,4].…”