Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats

Davari, Fatemeh; Alimanesh, Zeynab; Alimanesh, Zahra; Salehi, Omidreza; Hosseini, Seyed Ali

doi:10.1080/13813455.2020.1762663

Cited by 9 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In general, Tfam is regulated by the Pgc-1 coactivator, and Nrf-1 binds together and forms a heterodimer for regulating mitochondrial function (Lu et al, 2020). The binding of Nrf-1 and Pgc-1 coactivator improves the transcription of Nrf-1 (Davari et al, 2020). Here, it is noteworthy to note that these pathways were lessened, corroborating mitochondrial bioenergetics' impairment linked with diabetes and fatty liver (Aguila et al, 2010).…”

Section: B Molecular Biogenesis Markerssupporting

confidence: 71%

See 1 more Smart Citation

Hepatic Mitochondria in Diet-induced Obese Mice (Stereology and Molecular Analysis)

et al. 2021

View full text Add to dashboard Cite

Section: B Molecular Biogenesis Markerssupporting

confidence: 71%

“…The alteration of mitochondria by lipid intake is mediated by the activation of mitochondrial biogenesis generated by Tfam, Pgc-1, and Nrf-1 (Davari et al, 2020). In general, Tfam is regulated by the Pgc-1 coactivator, and Nrf-1 binds together and forms a heterodimer for regulating mitochondrial function (Lu et al, 2020).…”

Section: B Molecular Biogenesis Markersmentioning

confidence: 99%

Hepatic Mitochondria in Diet-induced Obese Mice (Stereology and Molecular Analysis)

et al. 2021

View full text Add to dashboard Cite

“…The testosterone groups received 2 mg/kg (11) testosterone propionate subcutaneously. At the end of the research period, all rats were anesthetized by xylazine 2% (10 mg/kg) and ketamine 10% (50 mg/kg) (12). Then, bone tissue was extracted and transferred to the laboratory.…”

Section: Methodsmentioning

confidence: 99%

Effect of Resistance Training with Palm Pollen and Testosterone on Runx2 Protein and Gene Expression Levels in Bone Tissue of Adult Male Rats

Payandeh

Peeri

Azarbayjani

et al. 2020

Hormozgan medical journal

Self Cite

View full text Add to dashboard Cite

Background: A healthy lifestyle, nutrition, and exercise can improve bone mass via several mechanisms. Objectives: This study assessed the effects of four weeks of palm pollen consumption along with resistance training on protein and gene expression levels of Runt-related transcription factor 2 (Runx2) in bone tissue of rats. Methods: Thirty-six rats were selected and assigned into six groups, including (1) training + testosterone, (2) training + palm pollen, (3) testosterone, (4) palm pollen, (5) training and (6) sham. Then, 100 mg/kg of palm pollen was prescribed five days per week. Resistance training was performed five sessions per week, and 2 mg/kg of testosterone propionate was prescribed peritoneally. Gene expression and protein levels of Runx2 were measured via the real-time PCR and Western blot methods. Results: Training had a significant effect on the increase in Runx2 protein levels (P ≤ 0.05). Training + testosterone, training + palm pollen, testosterone, and palm pollen had significant effects on gene expression and protein levels of Runx2 (P ≤ 0.05). Training + testosterone and training + palm pollen had more favorable effects on the increase of gene expression and protein levels of Runx2 than had testosterone, palm pollen, and training (P ≤ 0.05). Conclusions: Although training, palm pollen, and testosterone alone could increase the Runx2 protein levels in the bone tissue of rats, training with palm pollen and training with testosterone appeared to have more favorable effects on the increase of gene expression and protein levels of Runx2 than either alone.

show abstract

“…The prevalence of obesity and the harms of poor diet have led researchers to seek low-risk, non-invasive methods, such as exercise, to prevent or treat their complications (6). Exercise activates adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) in adipose tissues by activating the stimulating G protein subunit mechanism and cAMP-dependent protein kinase (PKA) phosphorylation (7,8).…”

Section: Introductionmentioning

confidence: 99%

“…the sympathetic system following physical activity activates beta-3 adrenergic receptors and GPCRs and phosphorylates HSL (9). In addition to physical activity, researchers recommend the use of dietary supplements for better results (6). Among them, Oct is an endogenous amine and the active ingredient of some plants, which has lipolysis effects, improves metabolism, and reduces inflammatory factors in adipose tissue by the mechanism of sympathetic nervous system activation and beta-3 adrenergic receptor and HSL phosphorylation (10,11).…”

Section: Introductionmentioning

confidence: 99%

Effect of Aerobic Training and Octopamine Supplementation on the Expression of Octopamine Receptors in the Visceral Adipose Tissue of Rats Exposed to Deep Fried Oils

2021

View full text Add to dashboard Cite

Background: The use of deep fried oils (DFOs) to cook foods is associated with numerous diseases. Although the role of physical activity and some supplements on fat lipolysis has been established, the effect of aerobic training (AT) and octopamine (Oct) on octopamine receptor-dependent lipolysis pathway is not well understood. Objectives: The present study aimed to investigate the effect of AT and Oct supplementation on the expression of Oct receptors in the visceral adipose tissue of DFO-exposed rats. Methods: In this experimental study, 30 male Wistar rats were divided into (1) healthy control (C), (2) DFO, (3) DFO + Oct, (4) DFO + AT, and (5) DFO + Oct + AT groups. Aerobic training was performed for four weeks, five sessions per week at an intensity of 16 - 26 m/min and equivalent to 50% - 65% VO2max, and Otc supplement was interperitoneally injected at 81 µmol/kg five days a week. Results: Aerobic training and Oct supplementation increased tyramin-R and hormone-sensitive lipase (HSL) (P ≤ 0.05), while Oct significantly decreased G protein-coupled receptors (GPCR) (P ≤ 0.05). Also, the interaction of AT and Oct on GPCR reduction was significant (P ≤ 0.05). Conclusions: It seems that AT and Otc alone improve octopamine receptors and lipolysis markers in the visceral adipose tissue of DFO-treated rats, but these two factors have no interactive effects on this pathway.

show abstract

Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats

Cited by 9 publications

References 26 publications

Hepatic Mitochondria in Diet-induced Obese Mice (Stereology and Molecular Analysis)

Hepatic Mitochondria in Diet-induced Obese Mice (Stereology and Molecular Analysis)

Effect of Resistance Training with Palm Pollen and Testosterone on Runx2 Protein and Gene Expression Levels in Bone Tissue of Adult Male Rats

Effect of Aerobic Training and Octopamine Supplementation on the Expression of Octopamine Receptors in the Visceral Adipose Tissue of Rats Exposed to Deep Fried Oils

Contact Info

Product

Resources

About