Effect of training on corticomotor excitability in clinical neck pain

Rittig-Rasmussen, Bjarne; Kasch, Helge; Fuglsang-Frederiksen, Anders; Svensson, Peter; Jensen, Troels Staehelin

doi:10.1002/j.1532-2149.2014.487.x

Cited by 9 publications

(17 citation statements)

References 60 publications

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“…In the present study (Rittig‐Rasmussen et al., ), the authors found that patients with neck pain who underwent a 20‐min weight lifting training session actually presented a decrease in MEP amplitudes compared with baseline values, which could be detected 30 min after training. However, knee pain patients who also underwent the same training programme presented an increase in MEP amplitudes up to an hour after training.…”

supporting

confidence: 52%

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Motor training‐induced cortical plastic changes and its disruption by chronic pain: A puzzle with more pieces than expected

Andrade

2014

European Journal of Pain

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supporting

confidence: 52%

“…In this issue, you will find a paper by Rittig‐Rasmussen et al. titled ‘Effect of training on corticomotor excitability in clinical neck pain’ (Rittig‐Rasmussen et al., ). In this study, the authors compared the effects of motor neck training on corticomotor excitability in patients with neck pain, patients with knee pain and healthy volunteers.…”

mentioning

confidence: 99%

Motor training‐induced cortical plastic changes and its disruption by chronic pain: A puzzle with more pieces than expected

Andrade

2014

European Journal of Pain

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“…Our data indicated that pain induction resulted in a significant decrease in MEP amplitude in the absence of pcTBS intervention. This finding is consistent with previous studies in which MEP amplitude was reduced by chronic pain (Lefaucheur et al, 2006;Cosentino et al, 2014;Rittig-Rasmussen et al, 2014;Parker et al, 2016). Reduced motor cortical output is associated with the imbalance of neurotransmission in the central nervous system evoked by the ascending transmission of nociception.…”

Section: Discussionsupporting

confidence: 93%

Prolonged Continuous Theta Burst Stimulation to Demonstrate a Larger Analgesia as Well as Cortical Excitability Changes Dependent on the Context of a Pain Episode

Liu

Che

et al. 2022

Front. Aging Neurosci.

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A series of neuropathic pain conditions have a prevalence in older adults potentially associated with declined functioning of the peripheral and/or central nervous system. Neuropathic pain conditions demonstrate defective cortical excitability and intermissions, which raises questions of the impact of pain on cortical excitability changes and when to deliver repetitive transcranial magnetic stimulation (rTMS) to maximize the analgesic effects. Using prolonged continuous theta-burst stimulation (pcTBS), a relatively new rTMS protocol to increase excitability, this study was designed to investigate pcTBS analgesia and cortical excitability in the context of pain. With capsaicin application, twenty-nine healthy participants received pcTBS or Sham stimulation either in the phase of pain initialization (capsaicin applied) or pain ascending (20 min after capsaicin application). Pain intensity was measured with a visual-analogic scale (VAS). Cortical excitability was assessed by motor-evoked potential (MEP) and cortical silent period (CSP) which evaluates corticospinal excitability and GABAergic intracortical inhibition, respectively. Our data on pain dynamics demonstrated that pcTBS produced a consistent analgesic effect regardless of the time frame of pcTBS. More importantly, pcTBS delivered at pain initialization induced a larger pain reduction and a higher response rate compared to the stimulation during pain ascending. We further provide novel findings indicating distinct mechanisms of pcTBS analgesia dependent on the context of pain, in which pcTBS delivered at pain initialization was able to reverse depressed MEP, whereby pcTBS during pain ascending was associated with increased CSP. Overall, our data indicate pcTBS to be a potential protocol in pain management that could be delivered before the initialization of a pain episode to improve rTMS analgesia, potentially through inducing early corticospinal excitability changes that would be suppressed by nociceptive transmission.

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“…The majority of the included articles focused on chronic pain conditions (n = 10) (Baarbe et al, 2018 ; Hoeger Bement et al, 2014 ; Masse-Alarie et al, 2016 , 2017b ; Mendonca et al, 2016 ; Parker et al, 2017 ; Rittig-Rasmussen et al, 2014a ; Schwenkreis et al, 2011 ; Tsao et al, 2010 ; Vallence et al, 2013 ), and the remaining articles focused on acute pain in healthy individuals (n = 7) (Boudreau et al, 2007 ; Dancey et al, 2019 ; De Martino, Petrini, et al, 2018 ; De Martino, Zandalasini, et al, 2018 ; Ingham et al, 2011 ; Mavromatis et al, 2017 ; Rittig-Rasmussen et al, 2014b ). The chronic pain conditions included headache (n = 1), pain in the neck region (n = 2), lower back pain (n = 3), painful hand arthritis (n = 1) and fibromyalgia (n = 3).…”

Section: Resultsmentioning

confidence: 99%

Pain’s Adverse Impact on Training-Induced Performance and Neuroplasticity: A Systematic Review

Stanisic

Häggman‐Henrikson

Kothari

et al. 2022

Brain Imaging and Behavior

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Motor training is a widely used therapy in many pain conditions. The brain’s capacity to undergo functional and structural changes i.e., neuroplasticity is fundamental to training-induced motor improvement and can be assessed by transcranial magnetic stimulation (TMS). The aim was to investigate the impact of pain on training-induced motor performance and neuroplasticity assessed by TMS. The review was carried out in accordance with the PRISMA-guidelines and a Prospero protocol (CRD42020168487). An electronic search in PubMed, Web of Science and Cochrane until December 13, 2019, identified studies focused on training-induced neuroplasticity in the presence of experimentally-induced pain, 'acute pain' or in a chronic pain condition, 'chronic pain'. Included studies were assessed by two authors for methodological quality using the TMS Quality checklist, and for risk of bias using the Newcastle–Ottawa Scale. The literature search identified 231 studies. After removal of 71 duplicates, 160 abstracts were screened, and 24 articles were reviewed in full text. Of these, 17 studies on acute pain (n = 7) or chronic pain (n = 10), including a total of 258 patients with different pain conditions and 248 healthy participants met the inclusion criteria. The most common types of motor training were different finger tasks (n = 6). Motor training was associated with motor cortex functional neuroplasticity and six of seven acute pain studies and five of ten chronic pain studies showed that, compared to controls, pain can impede such trainings-induced neuroplasticity. These findings may have implications for motor learning and performance and with putative impact on rehabilitative procedures such as physiotherapy.

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Effect of training on corticomotor excitability in clinical neck pain

Cited by 9 publications

References 60 publications

Motor training‐induced cortical plastic changes and its disruption by chronic pain: A puzzle with more pieces than expected

Motor training‐induced cortical plastic changes and its disruption by chronic pain: A puzzle with more pieces than expected

Prolonged Continuous Theta Burst Stimulation to Demonstrate a Larger Analgesia as Well as Cortical Excitability Changes Dependent on the Context of a Pain Episode

Pain’s Adverse Impact on Training-Induced Performance and Neuroplasticity: A Systematic Review

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