Effect of tramadol abuse on testicular tissue of adult albino rats

Sawy, Marwa M. El; Malak, Hany W. Abdel

doi:10.1097/01.ehx.0000464775.44998.4a

Cited by 10 publications

(6 citation statements)

References 38 publications

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“…Darkly stained nuclei were sloughed into the tubular lumen. The mean values of seminiferous tubules diameter and the mean germinal epithelial height were significantly decreased [21] .…”

Section: Discussionmentioning

confidence: 90%

“…Each tablet is suspended in 20 ml distilled water. It was given as 50mg/kg body weight daily by intragastric gavage for 4 weeks [7] .…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

“…-Group III: (Tramadol treated group): it included 10 animals that received Tramadol at a dose of 50 mg/kg body weight daily orally by intragastric gavage for 4 weeks [7] .…”

Section: Experimental Protocolmentioning

confidence: 99%

“…long-term administration of Tramadol has many complications as psychological addiction, physical addiction, respiratory depression [6] , negative effects on testis, liver, thyroid gland and kidney [7,8] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Histological and Immunohistochemical Study of Tramadol Induced Testicular Toxicity and Protective Effects of Resveratrol in Adult Male Albino Rats

Bana

Sarg

Elwakeel

2019

Journal of Medical Histology

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“…Darkly stained nuclei were sloughed into the tubular lumen. The mean values of seminiferous tubules diameter and the mean germinal epithelial height were significantly decreased [21] .…”

Section: Discussionmentioning

confidence: 90%

“…Each tablet is suspended in 20 ml distilled water. It was given as 50mg/kg body weight daily by intragastric gavage for 4 weeks [7] .…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

“…-Group III: (Tramadol treated group): it included 10 animals that received Tramadol at a dose of 50 mg/kg body weight daily orally by intragastric gavage for 4 weeks [7] .…”

Section: Experimental Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Histological and Immunohistochemical Study of Tramadol Induced Testicular Toxicity and Protective Effects of Resveratrol in Adult Male Albino Rats

Bana

Sarg

Elwakeel

2019

Journal of Medical Histology

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“…Besides, tramadol is used as an effective form of treatment for mild to severe premature ejaculation at therapeutic doses (Bar-Or et al, 2012). Generally, endogenous and exogenous opioids, modulate the gonadotropin-releasing hormone by targeting the opioid receptors in the hypothalamus and so reducing the LH and FSH release that have a direct effect on testosterone production in testes (El Sawy & Malak, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cross Talk Between Down Regulation of Steroidogenic Genes Expression, Oxidative and Apoptotic Biomarkers in Testes Induced by Administration of Tramadol and Boldenone and Their Combination in Male Albino Rats

Asaad¹,

Mowaad

El-Shamarka

et al. 2021

Preprint

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BackgroundThe testis is the male reproductive gland or gonad having two vital functions - to produce both sperm and androgens, primarily testosterone.PurposeThe study aimed to investigate the effect of tramadol and boldenone injected alone or in combinatio for 2 months in rats on testicular function.MethodsGroup 1; normal control, Group 2; tramadol Hcl (TRAM) (20 mg/kg bwt.) (i.p). Group 3; boldenone undecylenate (BOLD) (5 mg/kg bwt) (i.m). Group 4; combination of TRAM (20 mg/kg bwt.) and BOLD (5 mg/kg), respectively for 2 months.ResultsTRAM and BOLD alone and in combination rats showed deteriorated testicular functions, lowered serum steroid levels (FSH, LH and testesterone), elevation in oxidative biomarkers (MDA & NO) and reduction in GSH and SOD, downregulation of StaR and HSD17B3 as well as assessment of testicular histopathological using H&E staining, PAS stain for histochemical assessment of polysaccharides and glycoproteins in the testes and Masson trichrome stain to assess the changes in the collagen fibers.ConclusionThe study illuminated the hazard of administration of these drugs for a long period as well as the prominent deleterious effects reported on concurrent use of both drugs.

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Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil) and opioid (tramadol)

Nna

Akpan

Osim

2016

Asian Pacific Journal of Reproduction

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Effect of tramadol abuse on testicular tissue of adult albino rats

Cited by 10 publications

References 38 publications

The Histological and Immunohistochemical Study of Tramadol Induced Testicular Toxicity and Protective Effects of Resveratrol in Adult Male Albino Rats

The Histological and Immunohistochemical Study of Tramadol Induced Testicular Toxicity and Protective Effects of Resveratrol in Adult Male Albino Rats

Cross Talk Between Down Regulation of Steroidogenic Genes Expression, Oxidative and Apoptotic Biomarkers in Testes Induced by Administration of Tramadol and Boldenone and Their Combination in Male Albino Rats

Hyperprolactinemia contributes to reproductive deficit in male rats chronically administered PDE5 inhibitors (sildenafil and tadalafil) and opioid (tramadol)

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