Effect of transcranial direct current stimulation (tDCS) delivered via dorsolateral prefrontal cortex on central post-stroke pain and depression: a case report

Hassan, Auwal Bello; Danazumi, Musa Sani; Abdullahi, Auwal; Yakasai, Abdulsalam Mohammed

doi:10.1080/09593985.2021.1891591

Cited by 11 publications

(11 citation statements)

References 40 publications

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“…While in An's studies, conventional occupational therapy was used as the concomitant task. No other intervention or pharmacological treatment was mentioned in Hassan and Valiengo's studies ( 42 , 43 , 45 ) except for tDCS.…”

Section: Resultsmentioning

confidence: 99%

“…Six experimental studies of PSD were included in this systematic review ( 40 – 45 ) with tDCS treatment. The methodological quality of Valiengo's randomized, placebo-controlled clinical trial (RCT) was high, with a mean PEDro score of 8 out of 10 (level 1b evidence).…”

Section: Resultsmentioning

confidence: 99%

“…Both Li et al and An et al had a control group and were rated as level 3 on the modified Sackett Scale. The case series study ( 42 ) and the case reports ( 41 , 45 ) were considered as level 4 and 5 evidence, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Transcranial direct current stimulation for the treatment of post-stroke depression: A systematic review

et al. 2023

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BackgroundPost-stroke depression (PSD) is not only a frequent neuropsychiatric manifestation secondary to stroke but is also associated with disability, poor rehabilitation outcomes, sleep disorders, cognitive impairment, and increased mortality. Transcranial direct current stimulation (tDCS), a primary modality of non-invasive brain stimulation (NIBS), has shown promising clinical results in the rehabilitation of patients with PSD recently. The primary aim of this systematic review is to assess the effects of tDCS on PSD.MethodsPubMed and Cochrane databases were used for paper identification up to May 2022. Only English language studies and published data were taken into consideration. The methodological quality of selected studies was assessed according to the modified Sackett Scale, based on Physiotherapy Evidence Database (PEDro) scores.ResultsSix experimental studies were included for the PSD treatment of tDCS and all of them reported that, following the intervention of tDCS, the experimental group shows a statistically significant decrease in the depression level in accordance with different assessment scales.ConclusionThis article simply aims at providing a comprehensive overview of the raw data reported in this field to date. Based on the current evidence, tDCS presents promising results for the treatment of PSD. Moreover, tDCS is also effective in PSD patients with aphasia or CPSP. However, an optimal stimulation protocol is needed to formulate. Thus, the development of robustly controlled, randomized, and high-quality clinical trials to further assess the utility of tDCS as a therapeutic tool for the treatment of PSD survivors is encouraged.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023322076, identifier: CRD42023322076.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Transcranial direct current stimulation for the treatment of post-stroke depression: A systematic review

et al. 2023

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“…Notably, regulating depression and anxiety is an important reason for the improvement of chronic pain (Marshall et al, 2017 ). Many studies have shown that tDCS stimulation improves patients' depression symptoms and reduces pain intensity (Lorenz et al, 2003 ; Khedr et al, 2017 ; Hassan et al, 2021 ). Given the connection between pain, depression, and anxiety, we could expect that reduced depression or anxiety may decrease pain.…”

Section: Discussionmentioning

confidence: 99%

Is transcranial direct current stimulation beneficial for treating pain, depression, and anxiety symptoms in patients with chronic pain? A systematic review and meta-analysis

Wen

Shi

et al. 2022

Front. Mol. Neurosci.

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BackgroundChronic pain is often accompanied by emotional dysfunction. Transcranial direct current stimulation (tDCS) has been used for reducing pain, depressive and anxiety symptoms in chronic pain patients, but its therapeutic effect remains unknown.ObjectivesTo ascertain the treatment effect of tDCS on pain, depression, and anxiety symptoms of patients suffering from chronic pain, and potential factors that modulate the effectiveness of tDCS.MethodsLiterature search was performed on PubMed, Embase, Web of Science, and Cochrane Library from inception to July 2022. Randomized controlled trials that reported the effects of tDCS on pain and depression and anxiety symptoms in patients with chronic pain were included.ResultsTwenty-two studies were included in this review. Overall pooled results indicated that the use of tDCS can effectively alleviate short-term pain intensity [standard mean difference (SMD): −0.43, 95% confidence interval (CI): −0.75 to −0.12, P = 0.007] and depressive symptoms (SMD: −0.31, 95% CI, −0.47 to −0.14, P < 0.001), middle-term depressive symptoms (SMD: −0.35, 95% CI: −0.58 to −0.11, P = 0.004), long-term depressive symptoms (ES: −0.38, 95% CI: −0.64 to −0.13, P = 0.003) and anxiety symptoms (SMD: −0.26, 95% CI: −0.51 to −0.02, P = 0.03) compared with the control group.ConclusiontDCS may be an effective short-term treatment for the improvement of pain intensity and concomitant depression and anxiety symptoms in chronic pain patients. Stimulation site, stimulation frequency, and type of chronic pain were significant influence factors for the therapeutic effect of tDCS.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=297693, identifier: CRD42022297693.

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“…Repetitive transcranial magnetic stimulation analgesic research has been relatively mature and applied to a variety of CNP treatments ( Lefaucheur et al, 2001 ; Lefaucheur, 2006 ; Ayache et al, 2016a ; Nardone et al, 2017 ; Quesada et al, 2018 ; Sun et al, 2019 ). The analgesic mechanisms of rTMS and tDCS are similar, which both alter cortical excitability and synaptic plasticity, regulate the release of related neurotransmitters, and affect the structural and functional connections of brain regions associated with pain processing and regulation ( Figure 4 ; Zheng et al, 2011 ; Thibaut et al, 2017 ; Hassan et al, 2021 ; Molero-Chamizo et al, 2021 ). tDCS has been studied in several studies and was able to manage pain effectively, but its optimal stimulation targets, stimulation intensity, and stimulation time for each type of CNP are still difficult to identify ( Iodice et al, 2017 ; Wen et al, 2017 ; Young et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Non-invasive Brain Stimulation for Central Neuropathic Pain

Yang

Zhang

et al. 2022

Front. Mol. Neurosci.

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The research and clinical application of the noninvasive brain stimulation (NIBS) technique in the treatment of neuropathic pain (NP) are increasing. In this review article, we outline the effectiveness and limitations of the NIBS approach in treating common central neuropathic pain (CNP). This article summarizes the research progress of NIBS in the treatment of different CNPs and describes the effects and mechanisms of these methods on different CNPs. Repetitive transcranial magnetic stimulation (rTMS) analgesic research has been relatively mature and applied to a variety of CNP treatments. But the optimal stimulation targets, stimulation intensity, and stimulation time of transcranial direct current stimulation (tDCS) for each type of CNP are still difficult to identify. The analgesic mechanism of rTMS is similar to that of tDCS, both of which change cortical excitability and synaptic plasticity, regulate the release of related neurotransmitters and affect the structural and functional connections of brain regions associated with pain processing and regulation. Some deficiencies are found in current NIBS relevant studies, such as small sample size, difficulty to avoid placebo effect, and insufficient research on analgesia mechanism. Future research should gradually carry out large-scale, multicenter studies to test the stability and reliability of the analgesic effects of NIBS.

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Effect of transcranial direct current stimulation (tDCS) delivered via dorsolateral prefrontal cortex on central post-stroke pain and depression: a case report

Cited by 11 publications

References 40 publications

Transcranial direct current stimulation for the treatment of post-stroke depression: A systematic review

Transcranial direct current stimulation for the treatment of post-stroke depression: A systematic review

Is transcranial direct current stimulation beneficial for treating pain, depression, and anxiety symptoms in patients with chronic pain? A systematic review and meta-analysis

Non-invasive Brain Stimulation for Central Neuropathic Pain

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