Effect of transcutaneous auricular vagus nerve stimulation on post-stroke dysphagia

Wang, Ying; He, Yuhui; Jiang, Linlin; Chen, Xiaoxu; Zou, Fengjiao; Yin, Ying; Li, Jiani; Li, Changqing; Zhang, Guifang; Ma, Jue; Niu, Lingchuan

doi:10.1007/s00415-022-11465-5

Cited by 13 publications

(11 citation statements)

References 37 publications

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“…16,137 Since the vagus nerve distributes to the skin of the external auditory canal and pinna, and vagal reflex responses have been observed upon auricular stimulation, taVNS has also been developed as a non-invasive tVNS modality for the treatment of various diseases. 138,139,144,145 Studies had demonstrated the efficacy and safety of taVNS combined with conventional rehabilitation training in acute stroke patients. 145 In combination with limb rehabilitation training, taVNS may improve coordinated activity of the muscle groups of upper arms by reducing post-stroke spasticity and increasing motor control.…”

Section: Elevation Of Pns Activitymentioning

confidence: 99%

“…Studies also indicated that taVNS can improve post‐stroke insomnia and cognitive performance 146,147 . Animal experiments had demonstrated that taVNS is an effective treatment strategy for patients and model rats with dysphagia after acute stroke 144,148 . However, to the best of our knowledge, no study has specifically investigated the relationship between taVNS and ICH outcome.…”

Section: Treatment Strategiesmentioning

confidence: 99%

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Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Kang,

Shi,

Liu

et al. 2024

CNS Neurosci Ther

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AimsAutonomic dysfunction with central autonomic network (CAN) damage occurs frequently after intracerebral hemorrhage (ICH) and contributes to a series of adverse outcomes. This review aims to provide insight and convenience for future clinical practice and research on autonomic dysfunction in ICH patients.DiscussionWe summarize the autonomic dysfunction in ICH from the aspects of potential mechanisms, clinical significance, assessment, and treatment strategies. The CAN structures mainly include insular cortex, anterior cingulate cortex, amygdala, hypothalamus, nucleus of the solitary tract, ventrolateral medulla, dorsal motor nucleus of the vagus, nucleus ambiguus, parabrachial nucleus, and periaqueductal gray. Autonomic dysfunction after ICH is closely associated with neurological functional outcomes, cardiac complications, blood pressure fluctuation, immunosuppression and infection, thermoregulatory dysfunction, hyperglycemia, digestive dysfunction, and urogenital disturbances. Heart rate variability, baroreflex sensitivity, skin sympathetic nerve activity, sympathetic skin response, and plasma catecholamine concentration can be used to assess the autonomic functional activities after ICH. Risk stratification of patients according to autonomic functional activities, and development of intervention approaches based on the restoration of sympathetic‐parasympathetic balance, would potentially improve clinical outcomes in ICH patients.ConclusionThe review systematically summarizes the evidence of autonomic dysfunction and its association with clinical outcomes in ICH patients, proposing that targeting autonomic dysfunction could be potentially investigated to improve the clinical outcomes.

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Section: Elevation Of Pns Activitymentioning

confidence: 99%

Section: Treatment Strategiesmentioning

confidence: 99%

Autonomic dysfunction and treatment strategies in intracerebral hemorrhage

Kang,

Shi,

Liu

et al. 2024

CNS Neurosci Ther

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“…55 To date, there have been 9 clinical studies of tVNS in stroke. [56][57][58][59][60][61][62][63][64] These are summarized in the Table.…”

Section: Clinical Evidence For Tvns In Strokementioning

confidence: 99%

“…In addition to upper limb recovery, there have been early promising studies of tVNS in other poststroke neurological deficits including urinary incontinence 60 and dysphagia. 63 Improved arm function after stroke can be driven by changes in muscular strength, postural stability, dexterity, spasticity, speed, and sensation 66 ; these are variably targeted by different rehabilitative interventions and variably measured by different clinical outcome measures. Of the 5 trials investigating tVNS in upper limb impairment, 2 used assistive robotic training, 56,61 2 used a combination of methods (postural control, neuromuscular facilitation, and sensory integration), 59,62 and 1 used repetitive task practice.…”

Section: Chronic Stroke and Rehabilitationmentioning

confidence: 99%

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tVNS in Stroke: A Narrative Review on the Current State and the Future

Baig,

Kamarova,

Bell

et al. 2023

Stroke

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Ischemic stroke is a leading cause of disability and there is a paucity of therapeutic strategies that promote functional recovery after stroke. Transcutaneous vagus nerve stimulation (tVNS) has shown promising evidence as a tool to reduce infarct size in animal models of hyperacute stroke. In chronic stroke, tVNS paired with limb movements has been shown to enhance neurological recovery. In this review, we summarize the current evidence for tVNS in preclinical models and clinical trials in humans. We highlight the mechanistic pathways involved in the beneficial effects of tVNS. We critically evaluate the current gaps in knowledge and recommend the key areas of research required to translate tVNS into clinical practice in acute and chronic stroke.

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