Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarction

Peng, Chaoquan; Yang, Ke; Xiang, Peng; Zhang, Chengxi; Zou, Liyuan; Wu, Xiao; Gao, Ya; Kang, Zhuang; He, Ke-Ke; Liu, Jinlai; Cheng, Mu-Hua; Wang, Jingfeng; Chen, Lin

doi:10.1016/j.ijcard.2011.05.077

Cited by 29 publications

(15 citation statements)

References 14 publications

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“…Analysis of cell surface markers demonstrated that the labeled cells expressed the same markers as the original transplanted cells. Peng et al confirmed these results in another similar porcine study, where SPIO labeled autologous MSCs were delivered by intracoronary infusion 1 week after MI 34. Hypointense areas were visible on MRI after a 3 week MRI follow-up period.…”

Section: Cardiovascular Cell Tracking With Mrimentioning

confidence: 68%

Non-invasive In-Vivo Imaging of Stem Cells after Transplantation in Cardiovascular Tissue

Mathiasen¹,

Kastrup²

2013

Theranostics

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Stem cell therapy for degenerative diseases, including ischemic heart disease is now a clinical reality. In the search for the optimal cell type for each patient category, many different stem cell subpopulations have been used. In addition, different cell processing procedures and delivery methods have been utilized. Moreover, choices of endpoints have varied between studies. Diverging results have been reported from clinical experiences, with some studies demonstrating promising results with improved cardiac function and reduced mortality and clinical symptoms, and others have seen no improvements. To better understand the underlying mechanisms of these results, a reverse translation from bedside to bench has been opened. Non-invasive cell tracking after implantation has a pivotal role in this translation. Imaging based methods can help elucidate important issues such as retention, migration and efficacy of the transplanted cells. Great effort is being made in finding new and better imaging techniques for different imaging modalities, and much have already been learned. But there are still many unanswered questions. In this review, we give an overview of the imaging modalities used for cell tracking and summarize the latest advances within the field.

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Section: Cardiovascular Cell Tracking With Mrimentioning

confidence: 68%

Non-invasive In-Vivo Imaging of Stem Cells after Transplantation in Cardiovascular Tissue

Mathiasen¹,

Kastrup²

2013

Theranostics

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“…This work is motivated by similar studies performed using MSC, which have been shown to improve cardiac function when injected into the heart post-MI. [59][60][61][62] A summary of AFSC implantation studies and results can be found in Table 4.…”

Section: Implantation Of Afsc After Myocardial Infarctmentioning

confidence: 99%

Amniotic Fluid-Derived Stem Cells for Cardiovascular Tissue Engineering Applications

Connell

Camci‐Unal

Khademhosseini

et al. 2013

Tissue Engineering Part B: Reviews

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Recent research has demonstrated that a population of stem cells can be isolated from amniotic fluid removed by amniocentesis that are broadly multipotent and nontumorogenic. These amniotic fluid-derived stem cells (AFSC) could potentially provide an autologous cell source for treatment of congenital defects identified during gestation, particularly cardiovascular defects. In this review, the various methods of isolating, sorting, and culturing AFSC are compared, along with techniques for inducing differentiation into cardiac myocytes and endothelial cells. Although research has not demonstrated complete and high-yield cardiac differentiation, AFSC have been shown to effectively differentiate into endothelial cells and can effectively support cardiac tissue. Additionally, several tissue engineering and regenerative therapeutic approaches for the use of these cells in heart patches, injection after myocardial infarction, heart valves, vascularized scaffolds, and blood vessels are summarized. These applications show great promise in the treatment of congenital cardiovascular defects, and further studies of isolation, culture, and differentiation of AFSC will help to develop their use for tissue engineering, regenerative medicine, and cardiovascular therapies.

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“…Treatment with autologous stem cells from bone marrow has been suggested to reduce myocardial damage in patients with AMI. Results from clinical trials are, however, conflicting with regard to improvement of left ventricular ejection fraction [5–10]. Possible mechanisms by which autologous bone marrow stem cells act are discussed to be cardiac transdifferentiation, paracrine effects, angiogenesis, and reduced apoptosis [11, 12].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction

Furenes

Opstad

Solheim

et al. 2014

Mediators of Inflammation

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Background. Matrix metalloproteinase-9 (MMP-9), regulated by tissue inhibitor of metalloproteinase-9 (TIMP-1) and the extracellular matrix metalloproteinase inducer (EMMPRIN), contributes to plaque instability. Autologous stem cells from bone marrow (mBMC) treatment are suggested to reduce myocardial damage; however, limited data exists on the influence of mBMC on MMPs. Aim. We investigated the influence of mBMC on circulating levels of MMP-9, TIMP-1, and EMMPRIN at different time points in patients included in the randomized Autologous Stem-Cell Transplantation in Acute Myocardial Infarction (ASTAMI) trial (n = 100). Gene expression analyses were additionally performed. Results. After 2-3 weeks we observed a more pronounced increase in MMP-9 levels in the mBMC group, compared to controls (P = 0.030), whereas EMMPRIN levels were reduced from baseline to 2-3 weeks and 3 months in both groups (P < 0.0001). Gene expression of both MMP-9 and EMMPRIN was reduced from baseline to 3 months. MMP-9 and EMMPRIN were significantly correlated to myocardial injury (CK: P = 0.005 and P < 0.001, resp.) and infarct size (SPECT: P = 0.018 and P = 0.008, resp.). Conclusion. The results indicate that the regulation of metalloproteinases is important during AMI, however, limited influenced by mBMC.

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Effect of transplantation with autologous bone marrow stem cells on acute myocardial infarction

Cited by 29 publications

References 14 publications

Non-invasive In-Vivo Imaging of Stem Cells after Transplantation in Cardiovascular Tissue

Non-invasive In-Vivo Imaging of Stem Cells after Transplantation in Cardiovascular Tissue

Amniotic Fluid-Derived Stem Cells for Cardiovascular Tissue Engineering Applications

The Influence of Autologous Bone Marrow Stem Cell Transplantation on Matrix Metalloproteinases in Patients Treated for Acute ST-Elevation Myocardial Infarction

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