Effect of transplanted mesenchymal stem cells from rats of different ages on the improvement of heart function after acute myocardial infarction

Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction

“…Data from our current study demonstrated that MSCs transplantation can indeed restore MI-induced heart dysfunction. This result is consistent with the findings from previous reports (Piao et al 2005; Grauss et al 2007; Wang et al 2008). Our salient finding is that MSC transplantation can significantly ameliorate or abrogate MI-induced echocardiographic, cardiomyocyte contractile and intracellular Ca 2+ dysfunction.…”

“…Our salient finding is that MSC transplantation can significantly ameliorate or abrogate MI-induced echocardiographic, cardiomyocyte contractile and intracellular Ca 2+ dysfunction. Although MSC transplantation may improve the overall heart function (Piao et al 2005; Wang et al 2008), our work revealed for the first time that the improved myocardial contractile function following MSC transplantation may be due to, at least in part, the beneficial effect of cell transplantation in individual cardiomyocytes from the area-at-risk. Nonetheless, the beneficial mechanical responses were coordinated with reduced apoptosis and facilitated angiogenesis but not fibrosis in post-MI myocardium following MSC treatment, indicating possible contributions of anti-apoptosis and angiogenesis in MSCs-exerted myocardial effect following MI.…”

“…One of the major adverse effects of MI in the hearts is the significantly reduced fraction shortening, which is in concert with increased LV end diastolic and end systolic diameters favoring dilation of LV chamber (Piao et al 2005; Wang et al 2008). This notion is supported by the findings from our present observation.…”

“…Among all maneuvers for post-MI treatment, one of the recent promising approaches is the myocardial cell transplantation which involves implantation of muscle cells, progenitor cells and pluripotent stem cells into the infarct region. Accumulating evidence indicates that transplantation of adult stem cells derived from bone marrow may exert a beneficial effect on the overall cardiac function (Piao et al 2005; Grauss et al 2007; Wang et al 2008). Makino and colleagues reported that bone marrow (BM)-derived mesenchymal stem cells (MSC) may be differentiated into the spontaneously beating cardiomyocytes in vitro (Hakuno et al 2002; Makino et al 1999; Tomita et al 2007).…”

Generation of electrophysiologically functional cardiomyocytes from mouse induced pluripotent stem cells

“…Furthermore, there is no evidence that stem cells derived from other sources, such as the bone marrow, are able to give rise to contractile cardiac cells after transplantation into the heart [6]. The therapeutic effect of stem cells is, thought to be, mediated by paracrine mechanisms, such as the release of cytokines and growth factors, which inhibit apoptosis and fibrosis formation, enhance contractility, and activate endogenous regenerative mechanisms [7,8]. Embryonic stem (ES) cells, a type of pluripotent stem cell derived from early developing embryos, can potentially differentiate into all cell types derived from the three germ layers, including cardiac lineages [9–11].…”