Effect of treadmill exercise on serum corticosterone, serum and hippocampal BDNF, hippocampal apoptosis and anxiety behavior in an ovariectomized rat model of post-traumatic stress disorder (PTSD)

Yakhkeshi, Reza; Roshani, Fatemeh; Akhoundzadeh, Kobra; Shafia, Sakineh

doi:10.1016/j.physbeh.2021.113629

Cited by 19 publications

(8 citation statements)

References 70 publications

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“…In agreement with Yakhkeshi et al [24] , our results showed that, in contrast to hippocampal BDNF, serum BDNF levels were lower. However, the direction of small variations in serum BDNF mirrored those in hippocampal BDNF, as it cannot easily pass the blood brain barrier due to its high molecular weight.…”

Section: Discussionsupporting

confidence: 93%

Neuroprotective And Therapeutic Effects of Exercise in Restraint Stress Induced Depression Like Behavior Albino Rat Model

Ibrahim,

Megahed,

Metwally

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Major depressive disorder (MDD) is considered to be a chronic high-risk, recurring mental illness affecting individual's feelings, cognition, and behaviors. Exercise may be a promising target for the treatment of depression but the processes underlying this association between mood and exercise intervention are still poorly understood. Objective: The current work is designed for assessment of beneficial effects of moderate swimming exercise on behavior and neurochemical parameters in a restraint-stress rat model of depression. Materials and Methods: Depression was induced via placing rats in individually into a cylindrical, transparent restraint tube for 2 h/day for 3 weeks. Swimming exercise training was analyzed for its potential health benefits both before and after a period of chronic restraint stress. Results: restraint stress induced depression like behavior, increased corticosterone (p<0.001), MDA (p=0.001) as well as inflammatory markers and decreased hippocampal BDNF (p=0.001) and SOD (p<0.05). swimming exercise was able to prevent and improve these behavioral and biochemical abnormalities. Conclusions: exposure to chronic stress induced depression. Swimming exercise training, on the other hand, has a moderate benefit in reducing these damages if it is undertaken after the stress period. This impact, however, is amplified when swimming exercise is conducted prior to then in combination with restraint stress.

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Section: Discussionsupporting

confidence: 93%

Neuroprotective And Therapeutic Effects of Exercise in Restraint Stress Induced Depression Like Behavior Albino Rat Model

Ibrahim,

Megahed,

Metwally

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…BDNF is a member of the neurotrophic family of proteins. It is extensively distributed in the mammalian central nervous system where it modulates brain development [ 31 ]. BDNF protects neurons from apoptosis in vivo [ 32 ] and in vitro [ 33 ] and is strongly beneficial for cerebral ischemic-reperfusion injury [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

TPPU Downregulates Oxidative Stress Damage and Induces BDNF Expression in PC-12 Cells

Lin

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Ischemia-reperfusion is an ongoing clinical challenge that can lead to a series of pathological changes including oxidative stress. The inhibition of soluble epoxide hydrolase inhibitor (sEH) by 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl]urea (TPPU) results in an anti-inflammatory, cardioprotective, and blood vessel growth-promoting effects. Therefore, this study focused on the protective effect of TPPU on a rat pheochromocytoma (PC-12) cell oxidative stress model induced by H2O2. Methods. CCK-8 and Hoechst 33342 were used to evaluate cell apoptosis and western blot to detect the apoptotic proteins and brain-derived neurotrophic factor (BDNF) expression. Result. The incubation with 100 μM, 50 μM, and 25 μM TPPU significantly increased PC-12 cell viability. Epoxyeicosatrienoic acid (EET) pretreatment also protected PC-12 cells from oxidative stress. In addition, TPPU reduced caspase-3 and Bax expression and induced Bcl-2 expression, and EETs exerted the same effect on caspase-3 expression as TPPU. A positive relationship was found between TPPU or EET incubation and BDNF expression. Conclusion. These results revealed that TPPU reduced PC-12 cell oxidative stress injury induced by H2O2 and promoted BDNF expression.

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“…Exercise alone did not affect anxiety-like behaviours. These results are not surprising as most of the anxiolytic effect of exercise have been described in rat models of pathological states such as post-traumatic stress disorder [ 98 ]; restraint stress [ 99 ]; or in ageing [ 100 ]. Finally, we found that exercise increased the swimming time in the FST in rats treated with antibiotics.…”

Section: Discussionmentioning

confidence: 89%

Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats

Nicolas,

Dohm-Hansen,

Lavelle

et al. 2024

Transl Psychiatry

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Lifestyle factors, especially exercise, impact the manifestation and progression of psychiatric and neurodegenerative disorders such as depression and Alzheimer’s disease, mediated by changes in hippocampal neuroplasticity. The beneficial effects of exercise may be due to its promotion of adult hippocampal neurogenesis (AHN). Gut microbiota has also been showed to be altered in a variety of brain disorders, and disturbances of the microbiota have resulted in alterations in brain and behaviour. However, whether exercise can counteract the negative effects of altered gut microbiota on brain function remains under explored. To this end, chronic disruption of the gut microbiota was achieved using an antibiotic cocktail in rats that were sedentary or allowed voluntary access to running wheels. Sedentary rats with disrupted microbiota displayed impaired performance in hippocampal neurogenesis-dependent tasks: the modified spontaneous location recognition task and the novelty suppressed feeding test. Performance in the elevated plus maze was also impaired due to antibiotics treatment. These behaviours, and an antibiotics-induced reduction in AHN were attenuated by voluntary exercise. The effects were independent of changes in the hippocampal metabolome but were paralleled by caecal metabolomic changes. Taken together these data highlight the importance of the gut microbiota in AHN-dependent behaviours and demonstrate the power of lifestyle factors such as voluntary exercise to attenuate these changes.

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Effect of treadmill exercise on serum corticosterone, serum and hippocampal BDNF, hippocampal apoptosis and anxiety behavior in an ovariectomized rat model of post-traumatic stress disorder (PTSD)

Cited by 19 publications

References 70 publications

Neuroprotective And Therapeutic Effects of Exercise in Restraint Stress Induced Depression Like Behavior Albino Rat Model

Neuroprotective And Therapeutic Effects of Exercise in Restraint Stress Induced Depression Like Behavior Albino Rat Model

TPPU Downregulates Oxidative Stress Damage and Induces BDNF Expression in PC-12 Cells

Exercise mitigates a gut microbiota-mediated reduction in adult hippocampal neurogenesis and associated behaviours in rats

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