Effect of treatment for Chlamydia pneumoniae and Helicobacter pylori on markers of inflammation and cardiac events in patients with acute coronary syndromes. South thames trial of antibiotics in myocardial infarction and unstable angina pectoris (STAMINA)

Is Helicobacter pylori infection a risk factor for acute coronary syndromes?

“…A few studies have reported an association with H. pylori infection and ACS. [40][41][42][43] However, H. pylori infection as a risk factor for IHD remains a controversial issue. In this study, therefore, we focused on incidence cases of ACS and closely investigated whether H. pylori infection is a risk factor or not for ACS.…”

Chronic Helicobacter pylori infection is associated with peripheral arterial disease

“…A small-scale controlled trial has already assessed the effi cacy of two antibiotic regimens for H. pylori in 325 patients with acute coronary syndrome. 24 Compared with the placebo group, patients treated with antibiotics for 1 week showed a signifi cant reduction of cardiac events (primarily admission for unstable angina) after 12 weeks and 1 year of follow-up. How this effect might occur is currently unclear.…”

Seasonal variation in acute myocardial infarction

“…In one large case-control study [31], prior use of antibiotics for infections to which bacteria were susceptible to tetracycline or quinolone antibiotics was associated with decreased risk of first-time acute myocardial infarction. In another study [32], antibiotic use against Helicobacter pylori and Chlamydia pneumoniae significantly reduced adverse cardiac events in patients with acute coronary syndromes, associated with a reduction in C-reactive protein levels.…”