Effect of treatment with inhaled corticosteroid on serum periostin levels in asthma

Hoshino, Makoto; Ohtawa, Junichi; Akitsu, Kenta

doi:10.1111/resp.12687

Cited by 44 publications

(37 citation statements)

References 31 publications

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“…35 Nuijsink et al also found a negative correlation between U-EDN levels and FEV 1 , but could not find any relation to other symptoms. 32 In previous studies, periostin has been linked to decreased lung function 33 and eosinophil inflammation, 41 however, not to severity of disease. Elevated FeNO levels have been related to faster lung function decline in difficult-to-treat asthma.…”

Section: Discussionmentioning

confidence: 95%

Fixed airflow obstruction relates to eosinophil activation in asthmatics

Mogensen

Alving

Dahlén

et al. 2018

Clin Experimental Allergy

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Background: Some asthmatics develop irreversible chronic airflow obstruction, for example, fixed airflow obstruction (fixed-AO). This is probably a consequence of airway remodelling, but neither its relation to inflammation nor which asthma biomarkers can be clinically useful are elucidated. We hypothesized that the presence of type 2 inflammation relates to fixed-AO. Objectives:To evaluate the presence of four markers for type 2 inflammation in fixed airflow obstruction among asthmatics.Methods: This was a cross-sectional study of 403 participants with asthma, aged 17-75 years, from three Swedish centres. Fixed airflow obstruction was defined as forced expiratory volume during the first second (FEV 1 ) over forced vital capacity (FVC) being below the lower limit of normal (LLN). The following type 2 inflammation markers were assessed: exhaled nitric oxide (FeNO), serum periostin, serum eosinophil cationic protein (S-ECP), and urinary eosinophil-derived neurotoxin (U-EDN).Results: Elevated U-EDN (values in the highest tertile, ≥65.95 mg/mol creatinine) was more common in subjects with fixed-AO vs. subjects without fixed-AO: 55% vs. 29%, P < 0.001. Elevated U-EDN related to increased likelihood of having fixed-AO in both all subjects and never-smoking subjects, with adjusted (adjusted for sex, age group, use of inhaled corticosteroids last week, atopy, early-onset asthma, smoking history, and packyears) odds ratios (aOR) of 2.38 (1.28-4.41) and 2.51 (1.04-6.07), respectively. In a separate analysis, having both elevated S-ECP (>20 μg/L) and U-EDN was related to having the highest likelihood of fixed-AO (aOR (95% CI) 6.06(2.32-15.75)). Elevated serum periostin or FeNO did not relate to fixed-AO. Conclusions and clinical relevance:These findings support that type 2 inflammation, and in particular eosinophil inflammation, is found in asthma with fixed-AO.This could indicate a benefit from eosinophil-directed therapies. Further longitudinal studies are warranted to investigate causality and relation to lung function decline.

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Section: Discussionmentioning

confidence: 95%

Fixed airflow obstruction relates to eosinophil activation in asthmatics

Mogensen

Alving

Dahlén

et al. 2018

Clin Experimental Allergy

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“…Other studies have found no differences between eosinophilic and noneosinophilic airway inflammation in terms of serum levels of periostin [41]. Some published studies have also concluded that adult patients with high levels of periostin show a better response to treatment with inhaled corticosteroids [42], omalizumab [44], or lebrikizumab (anti-IL-13) [44], suggesting that periostin is linked to increased inflammatory or immunological activity.…”

Section: Discussionmentioning

confidence: 98%

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Mena

Abejón

Vidigal

et al. 2017

J Investig Allergol Clin Immunol

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Background: Asthma is the most common chronic disease in children. Cases of severe asthma (SA) are underdiagnosed. Periostin is a biomarker for SA in adults, but its role in children is poorly understood. Objectives: The aims of the study were to estimate the percentage of cases of uncontrolled severe asthma (UcSA) in children with poorly controlled asthma and to evaluate the role of periostin as a biomarker. Materials and Methods: We performed an observational study in children aged 5 to 14 years with poorly controlled asthma. Demographic and clinical data were collected in addition to the results of the lung function test, the fraction of exhaled nitric oxide, the skin prick test, total IgE, specific IgE, blood eosinophil count, serum periostin, treatment, asthma control, and quality of life. Variables were compared between the group with UcSA and the other children. Results: Fifty children with poorly controlled asthma (72% male) were included. Nineteen children (38%) had UcSA. Most children had limitations in their activities of daily living and had visited the emergency department. In addition, 38% were hospitalized. Quality of life was poor. Only 42% of the children received appropriate treatment. The UcSA group was more likely to have a total IgE >500 kU A /mL (52.6% vs 19%, P=.02) and less likely to have serum periostin >1000 ng/mL (31.2% vs 63%, P=.04). Conclusions: In our setting, 38% of children with poorly controlled asthma have UcSA, which is associated with higher levels of total serum IgE and lower levels of serum periostin.

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“…IL‐13 stimulates mucin secretion and clinical studies suggest that periostin and IL‐13 are increased in severe asthma . Also, the goblet cell appears to be an immune effector cell .…”

Section: Introductionmentioning

confidence: 99%

Inhibition of IL‐13‐induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC

et al. 2016

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Background and objective: Serum periostin is increased in asthma and serves as a surrogate marker for IL-13 activity in the lung. Serum levels of periostin are the most robust biomarker predicting a favourable response to the anti-IL-13 drug, lebrikizumab. We investigated the mechanisms of IL-13 stimulation of periostin, the polarized secretion of periostin and whether periostin would have a direct effect on mucin secretion by airway cells. Methods: Normal human bronchial epithelial (NHBE) cells were cultured at air-liquid interface (ALI) in the presence of IL-13, and we evaluated the effect of the specific inhibitors, leflunomide (Janus kinase (JAK)/signal transducer and activator of transcription factor 6 (STAT6) inhibitor) or PD98059 (MEK/extracellular regulated protein kinase (ERK) inhibitor), on periostin production. We examined MUC5AC secretion from NHBE cells exposed to recombinant human (rh) periostin or IL-13 in the presence and absence of OC-20, a periostin-neutralizing antibody. Results: IL-13 induced periostin protein which was predominantly secreted towards the basal surface of the cells. Periostin production was much greater from goblet cells than ciliated cells (P < 0.001). Periostin production after exposure to IL-13 was attenuated by both leflunomide (P < 0.001) and PD98059 (P < 0.001). The addition of exogenous periostin modestly increased MUC5AC secretion (P < 0.01), but did not visibly change cell morphology. IL-13-induced MUC5AC secretion was attenuated by OC-20 (P < 0.01). Conclusion: Periostin production in differentiated airway cells is mediated by JAK/STAT6 and MEK/ERK pathways. Periostin secretion is much greater from immunologically active goblet cells. IL-13-driven mucin production is partially inhibited by OC-20.

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Effect of treatment with inhaled corticosteroid on serum periostin levels in asthma

Cited by 44 publications

References 31 publications

Fixed airflow obstruction relates to eosinophil activation in asthmatics

Fixed airflow obstruction relates to eosinophil activation in asthmatics

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Inhibition of IL‐13‐induced periostin in airway epithelium attenuates cellular protein expression of MUC5AC

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