Effect of Triglycyl-Lysine-Vasopressin on Skin Blood Flow and Blood Loss During Wound Excision in Patients With Burns

Garner, W.L.; Thomson, Philip D.; Moore, Nancy; Rodriguez, J. L.; Smith, David J.

doi:10.1097/00004630-199307000-00011

Cited by 11 publications

(3 citation statements)

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“…Laser Doppler flowmetry and LDPI have been used for prolonged, non-invasive monitoring of tissue viability and wound healing, and for the assessment of peripheral vascular disease, inflammation, ischemia, reperfusion, skin graft acceptance (take) and burn depth (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31). LDPI may prove useful in delineating the areas of damage that need to be debrided, avoiding areas with sufficient blood flow.…”

Section: S Ulphur Mustard [Bis(2-chloroethyl)sulphide; Sm]mentioning

confidence: 99%

“…The laser debrided πgrafted sites and sharply excised πgrafted sites behaved similarly. grafted groups, differences were seen between the sharp sites and NT sites on PS day 8, and between both the sharp and TX1A sites and NT sites on PS day 36 (no comparisons with the NT group could be made on PS days [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Differences were again noted between these SM-exposed sites and the softer mid-ventral control sites throughout the postsurgical observation period.…”

Section: Ballistometrymentioning

confidence: 99%

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Bioengineering methods employed in the study of wound healing of sulphur mustard burns

Graham

Schomacker

Glatter

et al. 2002

Skin Research and Technology

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Bioengineering methods were useful in evaluating multiple characteristics during wound healing: (i) reflectance colourimetry for skin colour, (ii) evaporimetry to measure transepidermal water loss as an indicator of barrier function, (iii) laser Doppler perfusion imaging to assess cutaneous blood flow, and (iv) ballistometry to measure the mechanical properties of skin hardness and elasticity. Perhaps the most useful method was evaporimetry, as a restored barrier function was the best indicator of healed wounds. The use of reflectance colourimetry and ballistometry will continue in future wound healing studies for their contributions in judging cosmetic and functional outcomes. While useful, laser Doppler perfusion imaging was found to be rather time consuming. This methodology will be limited in the future to burn depth estimation prior to treatment, and for evaluation of pharmaceuticals specifically designed to improve or sustain blood flow into damaged areas.

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Section: S Ulphur Mustard [Bis(2-chloroethyl)sulphide; Sm]mentioning

confidence: 99%

Section: Ballistometrymentioning

confidence: 99%

Bioengineering methods employed in the study of wound healing of sulphur mustard burns

Graham

Schomacker

Glatter

et al. 2002

Skin Research and Technology

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“…Bleeding is a major problem during early excision of burned skin [1]. Reducing blood loss during burn surgery is important for decreasing patient morbidity from hemodynamic derangement and minimizing the risk of transfusion-associated infections [2]. Different techniques have been used to reduce the intraoperative blood loss in burn surgery including warm saline-soaked pads, topical solutions of thrombin with or without adrenaline, topical vasoconstructors, compressive dressings or tourniquets, and vasopressin continuous intravenous infusion [3,4].…”

Section: Introductionmentioning

confidence: 99%

The Hemeostatic Efficacy of ANKAFERD after Excision of Full Thickness Burns: A Comparative Experimental Study in Rats

Çoban¹,

Özerol²,

Tanber³

et al. 2011

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Objective: In order to evaluate the effects of Ankaferd blood stopper (ABS) on post-excisional burn wound bleeding via monitoring early blood hemoglobin level changes and to make a comparison with a standart topical treatment, a controlled experimental study was conducted. Design and Interventions: A contact burn model of full-thickness injury with 30% TBSA was used. Following the burn injury, excisions of burned areas were done at postburn 48th hour. 24 male Spraque Dawley rats were divided into control, adrenaline, ABS-solution and ABS-pad treatment groups. In control group no treatment was done for bleeding, but the other three groups had topical treatments. Samples were taken at the begining of the study, just before and 1 hour after the burn wound excisions for measurement of haemoglobine (Hb) levels and additionally the external bleeding amounts were measured by weighing the topical pads. Measurements and main results: Baseline Hb levels of control, adrenaline, ABS-solution and ABS-pad treatment groups were 15.06 ± 0,83, 15,82 ± 0.83, 16.23 ± 1.14 and 15.16 ± 1.46 respectively. At the 48th hour of postburn injury, the Hb levels of these groups were 13.82 ± 0.58, 13.68 ± 1.26, 13.79 ± 0.90 and 13.57 ± 0.89. Mean blood loss amounts (ml) after burn wound excisions in groups were 1.44 ± 0.26, 0.65 ± 0.07, 0.53 ± 0.08 and 0.44 ± 0.09. Conclusions: ABS was found to be as effective as topical adrenaline on reducing excisional bleeding in the experimental burn injury model

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Advances in Perioperative and Critical Care of the Burn Patient

Kaiser

Kim

Sharar

et al. 2013

Advances in Anesthesia

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Effect of Triglycyl-Lysine-Vasopressin on Skin Blood Flow and Blood Loss During Wound Excision in Patients With Burns

Cited by 11 publications

References 0 publications

Bioengineering methods employed in the study of wound healing of sulphur mustard burns

Bioengineering methods employed in the study of wound healing of sulphur mustard burns

The Hemeostatic Efficacy of ANKAFERD after Excision of Full Thickness Burns: A Comparative Experimental Study in Rats

Advances in Perioperative and Critical Care of the Burn Patient

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