Effect of Trimethoprim-Sulfamethaxazole in Blastocystis Hominis Infection

Ok, Ülgen Z.; Girginkardeşler, Nogay; Balcıoğlu, Cüneyt; Ertan, Pelin; Pırıldar, Timur; Kilimcioğlu, Ali Ahmet

doi:10.1111/j.1572-0241.1999.01529.x

Cited by 68 publications

(35 citation statements)

References 20 publications

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“…Clinical features related to B. hominis include nausea, anorexia, abdominal pain, flatulence, and acute or chronic diarrhea (8). However other studies state an opponent view point and it is believed that other factors probably are the causing agents of these symptoms (7,(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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A Study of The Genetic Variability of Blastocystis hominis Isolates in Hamadan, West of Iran

Sardarian

Hajilooi

Maghsood

et al. 2012

Jundishapur J Microbiol

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Blastocystis hominis is a common protozoan parasite in the human and many other animals intestine. The parasite pathogenicity is still controversial. A few studies have been conducted on prevalence of B. hominis subtypes in Iran. The results of present study improve our knowledge on B. hominis subtypes in Iran and therefore we can do more investigations on pathogenicity potential of these subtypes in the future. Background:Blastocystis is a common protozoan parasite in mammals, birds, amphibians, reptiles, fish, arthropods, and annelids. This parasite has some subtypes, which pathogenicity status of them still remained controversial. Some of Blastocystis subtypes are potentially pathogenic to human. Objectives: This study has identified the Blastocystis hominis subtypes and their prevalence rates in Hamadan. Materials and Methods: During two months of summer 2011, a total number of 250 human fecal samples referred for parasitology examination to Beasat Hospital and a few clinical laboratories of Hamadan city were collected. The samples were examined by direct method and formalin-ether. 41 samples exhibited positive results for B. hominis thereby were cultured in Locke-egg medium. After the growth and in order to genotype identification, B. hominis isolates were amplified by PCR, using seven pairs of sequencestagged site primers. Results: In this study, three subtypes of B. hominis consisted of one [SB83], two [SB340] and three [SB227] were identified. The most dominant genotype was SB83 with 56.1 % frequency. The prevalence rate of genotype SB227 and SB340 were 22 % and 7.3 %, respectively. Coexistence of genotypes SB83 and SB227 was detected in 14.6 % of positive cases. Conclusions: This is the first study in Hamadan on genotyping of B. hominis, which may trigger other epidemiologic and zoonotic studies on different subtypes and hence control clinical manifestations of infection.

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Section: Introductionmentioning

confidence: 99%

“…The pathogenicity of B. hominis still has been debated. There are some reports supporting the pathogenic potential of this parasite (7). Clinical features related to B. hominis include nausea, anorexia, abdominal pain, flatulence, and acute or chronic diarrhea (8).…”

Section: Introductionmentioning

confidence: 99%

A Study of The Genetic Variability of Blastocystis hominis Isolates in Hamadan, West of Iran

Sardarian

Hajilooi

Maghsood

et al. 2012

Jundishapur J Microbiol

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“…The pathogenicity of B. hominis still has been debated. A report supporting the pathogenic potential of this parasite (Ok et al, 1999); that can be found in patients with or without gastrointestinal symptoms. Some of the symptoms associated with Blastocystis infection include abdominal pain, constipation, and diarrhea, alternating diarrhea and constipation and others (Qadri et al, 1989).…”

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confidence: 99%

Fecal calprotectin among patients infected with some protozoan infections

Salman¹,

Ali²,

Razaq³

2017

Int.J.Curr.Microbiol.App.Sci

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“…Eradikasyonun sağlanmaması durumunda D. fragilis için hastaya aynı dozda ikinci bir seknidazol kürü verilmesi, Blastocystis spp. için ise trimetoprim-sulfametaksazol (320 mg TMP, 1600 mg SMX) 7 gün verilmesi planlanmıştır (22). Sağaltım tamamlandık-tan bir hafta sonra kontroller tekrarlanmıştır.…”

Section: Introductionunclassified

İrrite Bağırsak Sendromunda Dientamoeba fragilis ve Blastocystis spp.'nin Rolü

Mumcuoğlu¹,

Coşkun²,

Aksu³

et al. 2013

TurkiyeParazitolDerg

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ÖZET Amaç: Bu çalışmada, irrite bağırsak sendromu (İBS) tanısı konulmuş hastalarda Dientamoeba fragilis ve Blastocystis spp. parazitlerinin sıklığı ve İBS oluşumuyla ilişkilerinin araştırılması amaçlanmıştır. Yöntemler: İBS tanısı almış 55 hastadan, akut gastroenterit şikayetleri olan 80 hastadan oluşan grubu 1'den (KG-1) ve sağlıklı 50 gönüllüden oluşan Kontrol Grubu 2'den (KG-2) toplanan dışkı örnekleri çalışmaya alınmıştır. Örnekler direkt mikroskobi, trikrom boyama ve spesifik kültür yapılarak incelenmiştir. Bulgular: Blastocystis spp. görülme sıklığı açısından İBS hasta grubu ile KG-1 arasında anlamlı fark görülmezken (p>0,05), KG-2 arasında anlamlı fark bulunmuştur (p<0,05). İBS hasta grubunda, direkt mikroskobide (X40) her sahada 5 ve üzeri Blastocystis spp. görülmesi kontrol gruplarından daha sıktır. Tedavi sonrası takiplerde 4 (%22,2) hasta şikayetlerinin tamamen geçtiğini bildirirken, 11 (%61,1) hasta diğer bulgularda hafifleme olmakla birlikte kabızlığın devam ettiğini, 3 (%16,7) hasta ise şikayetlerinde hiçbir değişiklik olmadığını bildirmiştir. Hiçbir örnekte D. fragilis tespit edilmemiştir. Sonuç: Hiçbir hastada D. fragilis tespit edilememiş olmasının nedeni bölgemizde bu parazitin infeksiyon oranının düşük olmasına bağlı olabilir. İBS hastalarında her mikroskobi sahasında (X40) 5 ve üzeri Blastocystis spp.'nin sık görülmesi ve bu hastaların önemli bir kısmında tedavi ile şikayetlerin gerilemesi, İBS ile Blastocystis spp. enfeksiyonları arasında bir bağlantı olabileceğini düşündürmüştür. (Turkiye Parazitol Derg 2013; 37: 73- Methods: Stool specimens collected from 55 IBS patients, 80 patients with gastroenteritis as control group 1 (CG-1) and 50 healthy volunteers as control group 2 (CG-2) were included the study. Samples were examined by direct microscopy, trichrome staining and culture methods. Results: While there was no significant difference in the prevalence of Blastocystis spp. between IBS patients and CG-1 (p>0.05), a significant difference was found between IBS and CG-2 (p<0.05). Patients with IBS were found to have five or more Blastocystis spp. per field than control groups. After eradication, all symptoms were cured in four patients, there were only constipation problems left in eleven patients and there were no changes in clinical findings in three patients. D. fragilis was not found in any of the samples. Conclusion:The reason we did not find any D. fragilis may be due to the low infection rate in the region. However, significantly having five or more Blastocystis spp. per field (X40) in IBS patients and regression of IBS symptoms after treatment in most of the patients suggested a possible link between IBS and Blastocystis spp. (Turkiye Parazitol Derg 2013; 37: 73-7)

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Effect of Trimethoprim-Sulfamethaxazole in Blastocystis Hominis Infection

Cited by 68 publications

References 20 publications

A Study of The Genetic Variability of Blastocystis hominis Isolates in Hamadan, West of Iran

A Study of The Genetic Variability of Blastocystis hominis Isolates in Hamadan, West of Iran

Fecal calprotectin among patients infected with some protozoan infections

İrrite Bağırsak Sendromunda Dientamoeba fragilis ve Blastocystis spp.'nin Rolü

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