Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract

Huether, Gerald; Pöeggeler, Burkhard; Reimer, Andreas; George, Annette

doi:10.1016/0024-3205(92)90402-b

Cited by 240 publications

(179 citation statements)

References 34 publications

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“…However, in pigs, neither lower circulating levels of insulin during the night (during the dark period) nor reduction of circulating levels of insulin due to exogenous melatonin have been reported to date. Regarding the effects of amino acids, tryptophan has been shown to enhance circulating levels of melatonin in rats, chicken, and goats (Huether, Poeggeler, Reimer, & George, 1992; Ma, Zhang, Song, Sun, & Jia, 2012). However, the effects of lysine have not been reported to date.…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary lysine levels and lighting conditions on intramuscular fat accumulation in growing pigs

Katsumata

Kobayashi

Ashihara

et al. 2018

Animal Science Journal

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This study was conducted to test our hypothesis that intramuscular fat (IMF) accumulation increases in pigs fed on a low lysine diet during the dark period than those fed on the same diet during the light period. Using barrows aged 6 weeks, we monitored whether serum glucose and insulin levels were affected by light conditions. Two diets with different levels of lysine, 0.78% (LL diet) and 1.37% (control diet) were prepared. Eight pigs were fed on the diet during the light period, while the remaining pigs were fed during the dark period. The pigs were fed either the LL diet or the control diet. Although IMF contents of Longissimus dorsi (LD) muscle were higher in the pigs fed on a LL diet (p < .05), the light conditions had no effect. Low dietary lysine caused reduction in serum glucose levels (p < .05) and serum insulin levels (p = .0613). However, they were also unaffected by the lighting conditions. To gain further insights, we determined the messenger RNA levels of insulin receptor, insulin receptor substrate 1, acetyl CoA carboxylase, and fatty acid synthase in LD and Rhomboideus muscles and in the liver.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary lysine levels and lighting conditions on intramuscular fat accumulation in growing pigs

Katsumata

Kobayashi

Ashihara

et al. 2018

Animal Science Journal

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“…In addition to the pineal gland, which is the major source of melatonin, other tissues like retina [35], gastrointestinal tract [36,37] , skin [38] and leukocytes [6] (both in peripheral blood [39] and in bone marrow [40,41]) synthesize melatonin. Melatonin produced by these nonendocrine organs is not regulated by circadian cycles but rather respond to other signals, exerting in fact a paracrine or autocrine effect [6].…”

Section: Melatonin Synthesis and Its Targetsmentioning

confidence: 99%

Melatonin: A pleiotropic molecule regulating inflammation

Radogna

Diederich

Ghibelli

2010

Biochemical Pharmacology

308

247

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Melatonin is a neurohormone produced by the pineal gland that regulates sleep and circadian functions. Melatonin also regulates inflammatory and immune processes acting as both an activator and inhibitor of these responses. Melatonin demonstrates endocrine, but also paracrine and autocrine effects in the leukocyte compartment: on one side, leukocytes respond to melatonin in a circadian fashion; on the other side, leukocytes are able to synthesize melatonin by themselves.With its endocrine and paracrine effects, melatonin differentially modulates pro-inflammatory enzymes, controls production of inflammatory mediators such as cytokines and leukotrienes and regulates the lifespan of leukocytes by interfering with apoptotic processes. Moreover, its potent anti-oxidant ability allows scavenging of oxidative stress in the inflamed tissues. The interesting timing of pro-and anti-inflammatory effects, such as those affecting lipoxygenase activity, suggests that melatonin might promote early phases of inflammation on one hand and contribute to its attenuation on the other hand, in order to avoid complications of chronic inflammation. This review aims at giving a comprehensive overview of the various inflammatory pathways regulated by this pleiotropic hormone.

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“…Release of melatonin from the digestive system can be a post-prandial effect [4,5] or a response to tryptophan administration [17]. These findings may account for some transient rises in melatonin, but hardly for the circadian rhythm in plasma concentration.…”

Section: Introductionmentioning

confidence: 99%

Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

Pöeggeler

Cornélissen

Huether

et al. 2005

Biomedicine & Pharmacotherapy

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In Göttingen, Germany, circadian variations in melatonin had been determined time-macroscopically in pineal glands, blood plasma and duodenum of chicken and rats. When these data were metaanalyzed, they agreed with the results from an independent survey on tissues from rats collected in a laboratory in Pécs, Hungary. In the latter study, tissues were analyzed chemically in Bratislava, Slovakia, and numerically in Minneapolis, MN, USA, all by single-and multiple-component cosinor and parameter tests. In rats and chickens, these inferential statistical procedures clearly demonstrated a lead in phase of the 24-h cosine curves best fitting all of the duodenal vs. those best fitting all of the pineal melatonin values in each species in 2 geographic (geomagnetic) locations. The 24-h cosine curve of circulating melatonin was found to be in an intermediate phase position. Mechanisms of the phase differences and the contribution of gastrointestinal melatonin to circulating hormone concentrations are discussed.

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Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract

Cited by 240 publications

References 34 publications

Effects of dietary lysine levels and lighting conditions on intramuscular fat accumulation in growing pigs

Effects of dietary lysine levels and lighting conditions on intramuscular fat accumulation in growing pigs

Melatonin: A pleiotropic molecule regulating inflammation

Chronomics affirm extending scope of lead in phase of duodenal vs. pineal circadian melatonin rhythms

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