Effect of tumor properties on energy absorption, temperature mapping, and thermal dose in 13.56-MHz radiofrequency hyperthermia

Prasad, Bibin; Kim, Subin; Cho, Woong; Kim, Suzy; Kim, Jung Kyung

doi:10.1016/j.jtherbio.2018.04.007

Cited by 45 publications

(31 citation statements)

References 48 publications

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“…Combined treatment led to significant apoptosis and tumor volume reduction in vivo [ 44 ]. This was dependent on the dielectric properties of the tumors, and the measurement of dielectric features provided suitable temperature-mapping results [ 90 ]. These data suggested that clinical treatment planning could be improved by noninvasive measurement of patient-related tumor-specific dielectric properties using, for instance, magnetic resonance electrical properties tomography (MREPT) and dictionary-based electric properties tomography (dbEPT).…”

Section: Combination With Radiotherapymentioning

confidence: 99%

“…However, other regulated cell death pathways including ferroptosis, autophagy, necroptosis, or parthanatos may also be induced by mEHT, which require further studies. (3) Although some preclinical studies showed a sizable tumor destruction effect of mEHT at lower temperature ranges of 38–40 °C linked to electric field [ 23 , 43 ] and dielectric properties of tumor tissues [ 90 ], most studies reviewed here used ≈42 °C. Since some clinical studies, best exemplified, for instance, in advanced cervical cancer [ 90 , 99 , 102 ], also showed lower peritumoral treatment temperatures (about 38.5–40 °C), the translation of preclinical results obtained at about 42 °C in clinical situations requires caution.…”

Section: Limitations Of the Presented Studiesmentioning

confidence: 99%

“…(3) Although some preclinical studies showed a sizable tumor destruction effect of mEHT at lower temperature ranges of 38–40 °C linked to electric field [ 23 , 43 ] and dielectric properties of tumor tissues [ 90 ], most studies reviewed here used ≈42 °C. Since some clinical studies, best exemplified, for instance, in advanced cervical cancer [ 90 , 99 , 102 ], also showed lower peritumoral treatment temperatures (about 38.5–40 °C), the translation of preclinical results obtained at about 42 °C in clinical situations requires caution. A dominant effect of hyperthermia in this lower temperature range is likely to be enhanced perfusion and improved reoxygenation, which will result in strong radiosensitization and chemosensitization [ 103 ].…”

Section: Limitations Of the Presented Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Krenács

Meggyesházi

Forika

et al. 2020

IJMS

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The benefits of high-fever range hyperthermia have been utilized in medicine from the Ancient Greek culture to the present day. Amplitude-modulated electro-hyperthermia, induced by a 13.56 MHz radiofrequency current (mEHT, or Oncothermia), has been an emerging means of delivering loco-regional clinical hyperthermia as a complementary of radiation-, chemo-, and molecular targeted oncotherapy. This unique treatment exploits the metabolic shift in cancer, resulting in elevated oxidative glycolysis (Warburg effect), ion concentration, and electric conductivity. These promote the enrichment of electric fields and induce heat (controlled at 42 °C), as well as ion fluxes and disequilibrium through tumor cell membrane channels. By now, accumulating preclinical studies using in vitro and in vivo models of different cancer types have revealed details of the mechanism and molecular background of the oncoreductive effects of mEHT monotherapy. These include the induction of DNA double-strand breaks, irreversible heath and cell stress, and programmed cells death; the upregulation of molecular chaperones and damage (DAMP) signaling, which may contribute to a secondary immunogenic tumor cell death. In combination therapies, mEHT proved to be a good chemosensitizer through increasing drug uptake and tumor reductive effects, as well as a good radiosensitizer by downregulating hypoxia-related target genes. Recently, immune stimulation or intratumoral antigen-presenting dendritic cell injection have been able to extend the impact of local mEHT into a systemic “abscopal” effect. The complex network of pathways emerging from the published mEHT experiments has not been overviewed and arranged yet into a framework to reveal links between the pieces of the “puzzle”. In this paper, we review the mEHT-related damage mechanisms published in tumor models, which may allow some geno-/phenotype treatment efficiency correlations to be exploited both in further research and for more rational clinical treatment planning when mEHT is involved in combination therapies.

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Section: Combination With Radiotherapymentioning

confidence: 99%

Section: Limitations Of the Presented Studiesmentioning

confidence: 99%

Section: Limitations Of the Presented Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Krenács

Meggyesházi

Forika

et al. 2020

IJMS

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“…Importantly, the combination of mEHT with chemotherapy in vitro and in vivo as well as with radiation therapy in vitro and in vivo show the broad application variability of the method in preclinical experiments, which was also shown in clinical phase in both chemotherapies and radiation therapies (See details below) [39][40][41][42][43][44]. The thermal dose with temperature mapping is also shown in vivo, as well as the radiation equivalent of mEHT is estimated [45,46]. mEHT causes massive apoptosis by exciting the death-toll receptors and transient reaction-potential channels of the membrane [47,48].…”

Section: Discussionmentioning

confidence: 92%

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Szász¹

2020

COR

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Hyperthermia treatment for solid tumors is a long-used, but poorly accepted method in clinical use. Modulated electro-hyperthermia (mEHT, trade name: oncothermia®) changes the paradigm, introduces a novel, cellularly selective and immunogenic cell-ruination. The mEHT method produces tumor-vaccination, presenting the unharmed genetic information of cancer cells to immune cells [1]. The mEHT method is approved in more than 30 countries. Its phase II/III clinical applications indicate a broad perspective.

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“…11,12 A method that uses a¯ber-optic probe, which is nonmetallic and nonelectrical in nature, can be used to measure the temperature in phantom and animal models. [13][14][15][16] In our previous research, we developed a technique for temperature measurement inside a deep tissue heated by an infrared laser to test the e±ciency of a laser moxibustion device using a thermal-imaging camera and thermocouples. 17 Various materials have been used as a substitute for skin in previous studies.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared laser irradiation of a multilayer agar-gel tissue phantom to induce thermal effect of traditional moxibustion

Cho

Prasad

Kim

2018

J. Innov. Opt. Health Sci.

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Traditional moxibustion therapy can stimulate heat and blood-vessel expansion and advance blood circulation. In the present study, a novel noncontact-type thermal therapeutic system was developed using a near-infrared laser diode. The device allows direct interaction of infrared laser light with the skin, thereby facilitating a controlled temperature distribution on the skin and the deep tissues below the skin. While using a tissue-mimicking phantom as a substitute for real skin, the most important optical and thermal parameters are the absorption/attenuation coefficient, thermal conductivity, and specific heat. We found that these parameters can be manipulated by varying the agar-gel concentration. Hence, a multilayer tissue-mimicking phantom was fabricated using different agar-gel concentrations. Thermal imaging and thermocouples were used to measure the temperature distribution inside the phantom during laser irradiation. The temperature increased with the increase in the agar-gel concentration and reached a maximum value under the tissue phantom surface. To induce a similar thermal effect of moxibustion therapy, controlled laser-irradiation parameters such as output power, wavelength and pulse width were obtained from further analysis of the temperature distribution. From the known optothermal properties of the patient’s skin, the temperature distribution inside the tissue was manipulated by optimizing the laser parameters. This study can contribute to patient-specific thermal therapy in clinics.

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Effect of tumor properties on energy absorption, temperature mapping, and thermal dose in 13.56-MHz radiofrequency hyperthermia

Cited by 45 publications

References 48 publications

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Modulated Electro-Hyperthermia-Induced Tumor Damage Mechanisms Revealed in Cancer Models

Towards the Immunogenic Hyperthermic Action: Modulated ElectroHyperthermia

Near-infrared laser irradiation of a multilayer agar-gel tissue phantom to induce thermal effect of traditional moxibustion

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