Effect of Turmeric on Serum Malondialdehyde in Oral Submucous Fibrosis

Kapgate, Tejashree Dashrath; Bhowate, Rahul; Dangore, Suwarna; Meshram, Mrunal; Lohe, Vidya K

doi:10.31782/ijcrr.2020.122313

Cited by 1 publication

(2 citation statements)

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“…Arecoline induces ROS generation and cell cycle arrest in human keratinocytes [22]. Compared to healthy subjects, OSMF patients had elevated levels of serum malondialdehyde (MDA) [8,[23][24][25][26], copper [27,28], LPO, ceruloplasmin [28,29], nitric oxide [30], calcium, magnesium, potassium, iron, conjugated dienes, and hydroxyl radicals [28]; as well as elevated levels of salivary 8-Hydroxy-2 -deoxyguanosine (8-OHdG) [31], 8-isoprostane [32,33], lactoperoxidase, and total protein [34]. Conversely, OSMF patients had relatively decreased levels of hydrogen peroxide (H 2 O 2 ) and sodium, compared to healthy controls [28].…”

Section: Oxidative Stress Biomarkers In the Pathogenesis Of Osmfmentioning

confidence: 99%

“…Serum samples from OSMF patients revealed increased MDA [24], ceruloplasmin [29], LPOs [8], nitric oxide [30], and decreased levels of beta-carotene, vitamin E [8], and SOD levels [30]. Human studies largely demonstrated elevated levels of oxidative stress biomarkers serum MDA [8,23,25,26,83], salivary 8-hydroxy-2 -deoxyguanosine [31], salivary 8isoprostane [33], salivary lactoperoxidase and total salivary protein [34], and serum copper [27,28], calcium, magnesium, potassium, iron, LPOs, conjugated dienes, and hydroxyl radicals [28]. MDA was found by two articles to be more significant with higher clinical OSMF staging and grading [8,83], while 8-OHdG (salivary oxidative stress biomarker) levels were almost double in OSMF patients [31].…”

Section: Oxidative Stress Biomarkers Is Osmfmentioning

confidence: 99%

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A Comprehensive Analysis of the Role of Oxidative Stress in the Pathogenesis and Chemoprevention of Oral Submucous Fibrosis

Saso

Ahmad

et al. 2022

Antioxidants

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Oral submucous fibrosis (OSMF) is a chronic oral potentially malignant disorder (OPMD). It is described as a scarring disease of the oral mucosa associated with excess oxidants and insufficient antioxidants. While it is becoming increasingly accepted that oxidative stress results in excessive accumulation of collagen and progressive fibrosis of the submucosal tissues, there is limited data regarding the moderation of oxidative stress to initiate or prevent OSMF. To assess the scope for mechanism-based approaches to prevent or reverse OSMF, we systematically evaluated the existing literature and investigated the role of oxidative stress in the pathogenesis and chemoprevention of OSMF. A search for relevant articles on PubMed and Scopus was undertaken using pre-defined inclusion and exclusion criteria. A total of 78 articles were selected in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The articles eligible for assessment investigated both OSMF and/or oxidative stress biomarkers or specific antioxidants. Both in vitro and human studies consistently demonstrated variations in oxidative stress biomarker levels in OSMF and revealed an increase in oxidative stress, paralleling the development of the disease. Furthermore, the use of antioxidant supplements was overall associated with an improvement in clinical outcomes. Having identified the significance of oxidative stress in OSMF and the therapeutic potential of antioxidant supplements, this scoping review highlights the need for further well-designed studies in the development of mechanism-based interventions for managing OSMF.

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