Effect of Two-Day Atorvastatin Pretreatment on Long-Term Outcome of Patients With Stable Angina Pectoris Undergoing Elective Percutaneous Coronary Intervention

Relationship between time of day and periprocedural myocardial infarction after elective angioplasty

“…Aside from technical factors, clopidogrel and statin pre-treatment have been shown to reduce the risk of PMI (Cuisset et al, 2008;Herrmann et al, 2002;Patti et al, 2005;Veselka et al, 2011). The patients included in our study had similar rate of clopidogrel and statin use with even higher rate in the afternoon group.…”

Update on the efficacy of statin treatment in acute coronary syndromes

“…More recently, several studies and a meta-analysis confirmed these findings, showing the effectiveness of a statin loading dose before PCI to improve short-term CV outcomes (RR 1Á08 [CI 95% 1Á02-1Á14]; P = 0Á01) [38,[40][41][42]. On the other hand, other clinical studies showed controversial results on this role for statins [28,30,34,36,37]. However, the small sample size of some randomized trials [34,36,37] and the observational design of other studies [28,30] may impair the statistical power and then their reliability to identify a protective effect over a long-term follow-up, as suggested by Lev and coworkers [33].…”

“…On the other hand, other clinical studies showed controversial results on this role for statins [28,30,34,36,37]. However, the small sample size of some randomized trials [34,36,37] and the observational design of other studies [28,30] may impair the statistical power and then their reliability to identify a protective effect over a long-term follow-up, as suggested by Lev and coworkers [33]. The mechanisms by which statins might prevent PCI-induced adverse CV events are still a matter of debate.…”

“…However, vascular injury following coronary angioplasty and stent displacement is still frequent and strongly worsen short-and longterm event-free survival [26]. Several studies reported that preoperative administration of statins might reduce the incidence of adverse effects after PCI [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] (Table 3). The Atorvastatin for Reduction of MYocardial Damage During Angioplasty-Acute Coronary Syndromes (ARMYDA-ACS) [29] and Novel Approaches for Preventing or Limiting Events (NAPLES) II trials [32] are the first large clinical trials supporting the use of a loading dose of atorvastatin (80 mg) before coronary PCI, to improve the short-term outcomes.…”

Effect of Statins Therapy Prior to Percutaneous Coronary Intervention

“…In conclusion, the authors suggested that 2-day therapy with highdose atorvastatin before PCI did not influence occurrence of periprocedural MI or long-term clinical outcomes. 19,20 Hüseyin et al 21 studied 93 patients which were divided into 3 groups: control group (n = 34), group receiving pravastatin at a dose of 10 mg per day (n = 30), and group receiving and 40 mg per day (n = 29). Blood samples were tested before and after PCI to measure serum CRP and neopterin levels.…”