Effect of Tympanic Perforations on the Detection of Distortion-product Otoacoustic Emissions

Abstract

The deteeti an of distort ion-p rodu ct otoaco ustic emissions (DPOA Es) depends on the viability of the ear's conduction apparatus. Ho wever, tympanic membrane perforations and other conductive disorders ha ve not been fu lly investigated with rega rd to the exa mination of DPOAEs. Using the gu inea pi g model, we made perfo rations ofdifferent sizes and loei on the tympa nic memb ran e and eollee ted DPOAE datafo rfrequencies between Z,193 and 5,508 Hz f or eaeh condi tion. We fo und that small p erfo rations, up to 25% of the are a of the tympani c membrane, still all ow us to deteet emissions at the speeifi ed freq uen cies. How ever, p erfo rations of 50 % and larger, as well as tho se accompanied by traumatic p erilymph fistula s and ossicular disarticulations, severely interfe red with the deteetian of DPOAEs. We discuss the clinical relevance of these findin gs with respeet to the potential uses of DPOAEs.

Study of distortion-product otoacoustic emissions during hypothermia in humans

“…This was clearly observed in the ANESTHESIA and HYPOTHERMIA series, as the data was collected in the operating room where low frequencies simply could not be properly recorded. A similar situation was described by LeBourgeouis III et al 29 .…”

“…They resorted to tympanometry and stapedial reflex studies but did not succeed in correlating the failure rate to alterations in the middle ear. Le Bourgeois III et al 29 , using animal models and looking at tympanic perforations of various sizes, were only able to find changes to DPOAE when perilymph fistulae were present. Therefore, although it may be said that changes in middle ear impedance during hypothermia could hinder DPOAE recording, we tend to agree with Seifert et al 11 and Kvolves et al 10 and conclude that OAE disappearance during hypothermia does not occur by the works of such mechanism.…”

Distortion product otoacoustic emissions: Sensitive measures of tympanic -membrane perforation and healing processes in a gerbil model

“…Mechanically-induced TM perforations have been shown to be similar to TM perforations caused by intense acoustic blasts (Cho et al, 2013), but the advantage of our study was that we could study these effects in isolation, i.e., without the confounding effects of multiple sites of damage to the ossicular chain, or a resulting sensorineural hearing loss. Similar to the published studies on TM perforations in the guinea pig and mouse (LeBourgeois et al, 2000;Qin et al, 2010;Ueda et al, 1998), 2-tone evoked DPOAEs were measurable with up to a 50% of TM perforation of the pars tensa and showed frequency-dependent systematic decreases in magnitude with increases in the size of TM perforations ( Figs. 2A, B & D).…”

Self‐Adhesive Silicone Microstructures for the Treatment of Tympanic Membrane Perforations

“…[ 27,28 ] The latter is an important frequency‐specific method to detect the functional effects of middle ear disorders, such as otitis media, TMPs, and discontinuity of the ossicular chain. [ 29–31 ] DPOAE measurements are a very sensitive tool to analyze mechanical alterations in the middle ear, among other things, and therefore can also be used to obtain information about the healing process of the perforated tympanic membrane. [ 32 ]…”