Effect of Ubiquinone 35 on Hypercitricemia

Tsunemitsu, Akira; Honjo, K.; Nakamura, Ryô; Kani, Misako; Matsumura, Tomohiro

doi:10.1902/jop.1968.39.4.215

Cited by 7 publications

(1 citation statement)

References 22 publications

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“…The effects of CoQ administration on hypercitricemia in both human patients and rats with PE (Tsunemitsu and Matsumura, 1967;Tsunemitsu et al, 1968;Matsumura et al, 1969a,b) were studied by the homologue CoO7, and prolonged administration of CoQ7 alleviated the histopathological alterations found in citrated rats (i.e., marked osteoporosis of the alveolar bone accompanied by myelofibrosis and atrophy of the periodontal ligament).…”

Section: Coo In Inflammatory Periodontal Diseasementioning

confidence: 99%

Oxidative Injury and Inflammatory Periodontal Diseases : the Challenge of Anti-Oxidants to Free Radicals and Reactive Oxygen Species

Battino

Bullón

Wilson

et al. 1999

Critical Reviews in Oral Biology & Medicine

284

266

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ABSTRACT. In recent years, there has been a tremendous expansion in medical and dental research concerned with free radicals, reactive oxygen species, and anti-oxidant defense mechanisms. This review is intended to provide a critical, up-to-date summary of the field, with particular emphasis on its implications for the application of "anti-oxidant therapy" in periodontal disease. We have reviewed the nomenclature, mechanisms of actions, features, and sources of most common free radicals and reactive oxygen species, as well as analyzed the typical biological targets for oxidative damage. Based on a review of direct and indirect anti-oxidant host defenses, particularly in relation to the key role of polymorphonuclear neutrophils in periodontitis, we review current evidence for oxidative damage in chronic inflammatory periodontal disease, and the possible therapeutic effects of anti-oxidants in treating and/or preventing such pathology, with special attention to vitamin E and Co-enzyme Q.

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Section: Coo In Inflammatory Periodontal Diseasementioning

confidence: 99%