Effect of Ultralow Doses of Antibodies to S-100 Protein in Animals with Impaired Cognitive Function and Disturbed Emotional and Neurological Status under Conditions of Experimental Alzheimer Disease

Воронина, Т. А.; Belopolskaya, M. V.; Kheyfets, I. A.; Duginа, Yu. L.; Сергеева, С. А.; Эпштейн, О. И.

doi:10.1007/s10517-010-0757-y

Cited by 7 publications

(6 citation statements)

References 4 publications

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“…La escopolamina es un antagonista de receptores muscarínicos que imita de manera aguda la enfermedad de Alzheimer (55) . Además, se demostró que ambos extractos de maca negra inhibieron la actividad de la acetilcolinesterasa, sin modificar los niveles de monoamino oxidasa (56) .…”

Section: Efecto De La Maca Sobre Memoria Depresión Y Ansiedadunclassified

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Gonzáles

Villaorduña

Gasco

et al. 2014

Rev Peru Med Exp Salud Publica

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RESUMENLa maca (Lepidium meyenii) es una planta que crece sobre los 4000 metros de altitud en los Andes Centrales del Perú, presenta diferentes variedades de acuerdo al color de su hipocótilo. La presente revisión resume los resultados de estudios sobre los efectos de la maca en la función sexual, la espermatogénesis, la función reproductiva femenina, la memoria, la depresión y la ansiedad, como energizante y contra la hiperplasia benigna de próstata, osteoporosis y síndrome metabólico. Se discute también su efecto antienvejecimiento y la seguridad en su consumo. Se han demostrado diferencias en el efecto de las variedades negra, amarilla y roja de maca. La maca negra es la que mejores resultados presenta sobre la espermatogénesis, la memoria y contra la fatiga, mientras que la maca roja es la variedad que mejor revierte la hiperplasia benigna de próstata y la osteoporosis inducida experimentalmente. Además, la maca reduce los niveles de glucosa, y su consumo se relaciona con la reducción de la presión arterial y un mejor puntaje de salud. Estudios experimentales han demostrado que el consumo a corto como a largo plazo no muestra toxicidad tanto in vivo como in vitro. A pesar que los estudios experimentales han demostrado que la maca presenta diversos efectos benéficos, son necesarios más estudios clínicos para confirmar estos resultados. Palabras clave: Espermatogénesis; Hiperplasia benigna prostática; Osteoporosis; Fatiga; Toxicidad (fuente: DeCS BIREME). MACA (Lepidium meyenii Walp), A REVIEW OF ITS BIOLOGICAL PROPERTIES ABSTRACTMaca (Lepidium meyenii) is a plant that grows above 4000 altitude meters in Peru's Central Andes; it has different varieties according to the color of the hypocotyl. This review summarizes the results of studies about the effects of maca on sexual function, spermatogenesis, female reproductive function, memory, depression and anxiety, and energy as well as effects on benign prostatic hyperplasia, osteoporosis and metabolic syndrome. Its anti-aging effect is also discussed as well as safety in consumption. Differences have been shown between the effects of the black, yellow and red maca varieties. Black maca shows the best results on spermatogenesis, memory and fatigue, while red maca is the variety that reverses the benign prostatic hyperplasia and experimentally induced osteoporosis. In addition, maca reduces the glucose levels, and its consumption is related to the lowering of blood pressure and an improved health score. Experimental studies have proven that short and long term consumption don't show in vivo and in vitro toxicity. Although experimental studies have shown that maca has diverse beneficial effects, more clinical studies are needed to confirm these results.

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Section: Efecto De La Maca Sobre Memoria Depresión Y Ansiedadunclassified

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Gonzáles

Villaorduña

Gasco

et al. 2014

Rev Peru Med Exp Salud Publica

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“…Ion capture changes a spatial organization ( Liu et al, 2013 ). A nerve injury induces a system of regeneration in vivo , including the excessive expression of the S100 protein and initiating neuroregeneration ( Voronina et al, 2009 ; Liu et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Allogenic Adipose Derived Stem Cells Transplantation Improved Sciatic Nerve Regeneration in Rats: Autologous Nerve Graft Model

et al. 2018

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We examined the effect of transplantation of allogenic adipose-derived stem cells (ADSCs) with properties of mesenchymal stem cells (MSCs) on posttraumatic sciatic nerve regeneration in rats. We suggested an approach to rat sciatic nerve reconstruction using the nerve from the other leg as a graft. The comparison was that of a critical 10 mm nerve defect repaired by means of autologous nerve grafting versus an identical lesion on the contralateral side. In this experimental model, the same animal acts simultaneously as a test model, and control. Regeneration of the left nerve was enhanced by the use of ADSCs, whereas the right nerve healed under natural conditions. Thus the effects of individual differences were excluded and a result closer to clinical practice obtained. We observed significant destructive changes in the sciatic nerve tissue after surgery which resulted in the formation of combined contractures in knee and ankle joints of both limbs and neurotrophic ulcers only on the right limb. The stimulation of regeneration by ADSCs increased the survival of spinal L5 ganglia neurons by 26.4%, improved sciatic nerve vascularization by 35.68% and increased the number of myelin fibers in the distal nerve by 41.87%. Moreover, we have demonstrated that S100, PMP2, and PMP22 gene expression levels are suppressed in response to trauma as compared to intact animals. We have shown that ADSC-based therapy contributes to significant improvement in the regeneration.

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“…A substantial body of animal experiments indicating that elevated levels of pro‐inflammatory cytokines are closely associated with cognitive impairment supports this hypothesis . Another molecule that has been used to predict cognitive dysfunction is S‐100β, which shows a correlation with cognitive function in patients after minor surgery, after cardiac surgery, or experimental Alzheimer's disease in animals . It is now increasingly used in the evaluation of cognitive function after traumatic brain injury …”

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confidence: 99%

Perioperative inflammatory response and protein S‐100β concentrations – relationship with post‐operative cognitive dysfunction in elderly patients

et al. 2012

Acta Anaesthesiol Scand

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Effect of Ultralow Doses of Antibodies to S-100 Protein in Animals with Impaired Cognitive Function and Disturbed Emotional and Neurological Status under Conditions of Experimental Alzheimer Disease

Cited by 7 publications

References 4 publications

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Maca (Lepidium meyenii WALP), una revisión sobre sus propiedades biológicas

Allogenic Adipose Derived Stem Cells Transplantation Improved Sciatic Nerve Regeneration in Rats: Autologous Nerve Graft Model

Perioperative inflammatory response and protein S‐100β concentrations – relationship with post‐operative cognitive dysfunction in elderly patients

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