Aluminum and its alloys are widely used in packaging, transportation, electrical materials, and many other fields because of their abundance, light weight, good mechanical properties, suitable corrosion resistance, excellent electrical conductivity, and other advantages. Grain refinement achieved by adding inoculant is important not only to reduce the segregation and thermal cracking of alloy castings but also to improve the mechanical properties of alloy castings. Therefore, fine equiaxed grain structure has always been one of the goals pursued by the aluminum alloy casting industry. For this reason, the selection and development of effective inoculants for aluminum alloy is a key technology in the aluminum processing industry. This paper summarizes the development history of inoculants for aluminum alloy, including Al-Ti-C, Al-Ti-B, Al-Ti, Al-Ti-B-(C)-Ce, Al-Sc, and the Fe-rich phase of Al-Si alloy. At the same time, the advantages and disadvantages of common inoculants are introduced and prospective future applications are reviewed.