Effect of ultrasonic treatment on the degradation and inhibition cancer cell lines of polysaccharides from Porphyra yezoensis

Yu, Xiaojie; Zhou, Cunshan; Yang, Hua; Huang, Xingyi; Ma, Haile; Qin, Xiaopei; Hu, Jiali

doi:10.1016/j.carbpol.2014.09.086

Cited by 103 publications

(67 citation statements)

References 27 publications

(23 reference statements)

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“…Although the IC 50 value (556.4 g/ml) of PSPP1-1 required for inhibiting tumor cells (SW620) is relatively high, others have shown that some excellent antitumor polysaccharides also have very high IC 50 values such as the polysaccharide SHP30 from Sargassum horneri (Its IC 50 value for inhibiting MKN45 cells is estimated to be 1000 g/ml) (Shao et al, 2014) and the polysaccharide GBEP from Ginkgo biloba sarcotesta (its IC 50 value for inhibiting U937 cells is estimated to be 640 g/ml) (Wu et al, 2011). The antitumor activity of polysaccharide may be related to monosaccharide composition, molecular size, structure and conformation (Yu et al, 2015). Previous studies observed that the polysaccharides with low molecular weight and high sulfate contents could The effects of PSPP1-1 on the apoptotic rates of SGC7901 and SW620 cells.…”

Section: Antitumor Activitiesmentioning

confidence: 97%

Characterization, antioxidant and antitumor activities of polysaccharides from purple sweet potato

Jia

et al. 2015

Carbohydrate Polymers

138

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Section: Antitumor Activitiesmentioning

confidence: 97%

Characterization, antioxidant and antitumor activities of polysaccharides from purple sweet potato

Jia

et al. 2015

Carbohydrate Polymers

138

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“…PRM3 exhibited the best anticancer activity and its IC50 value was 15.61 mg/mL. It was well-known that the anticancer activity of polysaccharide might be associated with its monosaccharide composition, molecular weight, and structural conformation [19,20]. Our previous study observed that PRM3 with moderate uronic acid contents and low molecular weight could exhibit potent anticancer activities in vitro [10].…”

Section: In Vitro Anticancer Activity Of Purified Fractionsmentioning

confidence: 90%

Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root

Jia

Zhang

et al. 2015

Molecules

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Box-Behnken design (BBD), one of the most common response surface methodology (RSM) methods, was used to optimize the experimental conditions for ultrasound-assisted extraction of polysaccharides from Rhynchosia minima root (PRM). The antioxidant abilities and anticancer activity of purified polysaccharide fractions were also measured. The results showed that optimal extraction parameters were as follows: ultrasound exposure time, 21 min; ratio of water to material, 46 mL/g; ultrasound extraction temperature, 63˝C. Under these conditions, the maximum yield of PRM was 16.95%˘0.07%. Furthermore, the main monosaccharides of purified fractions were Ara and Gal. PRM3 and PRM5 exhibited remarkable DPPH radical scavenging activities and reducing power in vitro. PRM3 showed strong inhibitory activities on the growth of MCF-7 cells in vitro. The above results indicate that polysaccharides from R. minima root have the potential to be developed as natural antioxidants and anticancer ingredients for the food and pharmaceutical industries.

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“…Laurencia okamurai Yamada derived secolaurokamurone, four laurane-type sesquiterpenes, laurepoxyene, 3β-hydroperoxyaplysin, 3α-hydroperoxy-3-epiaplysin, and 8,10-dibromoisoaplysin, one laurokamurane-type sesquiterpene, laurokamurene D, and one bisabolane-type sesquiterpene, (5S)-5-acetoxy-β-bisabolene, induced cytotoxicity against HL-60 and A-549 human cancer cell lines (Table 2). These compounds studied displayed moderate activities, relative to controls [35]. It was for the first time found that Laurencia okamurai extract containing laurinterol (LOEL) exhibited an excellent effect on the induction of apoptosis as determined by DNA fragmentation, terminal deoxynucleotidyl transferase-mediated dUTP in situ nick-end labeling assay, cell cycle analysis, and measurement of activities of several caspases in melanoma cells.…”

Section: Laurenciamentioning

confidence: 97%

Algae as potential repository of anti cancerous natural compounds

Mridha¹,

Paul²

2017

ijpm

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Algae constitute a promising source of novel compounds with potential as human therapeutic agents. In particular, algae have been considered as a potential source of new bio-active compound. Algae possess several biological activities, including anticancer activity. This review provides a comprehensive report on the several genera of algae belonging to Chlorophyceae, Pheophyceae and Rhodophyceae having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action in vitro as well as in vivo condition. Algae are extensively used as functional foods and medicinal herbs, and have a long history of use in Asian countries. Many algae have been used for the treatment of cancer, many crude or partially purified polysaccharides from various brown, green, and red algae have been tested for their antitumor activities. Relevant information was collected from scientific journals, books, and reports via library and electronic search using Medline, Pubmed, Science Direct, and Scopus. The different extracts with some other solvent shows a huge anti-proliferative action on different cancer as well as on different leukemia cell lines. Here we focus on several bioactive compounds that have been derived as well as characterized from different genera of algae and there mechanism of inhibiting cancer cell growth. Considering the ability of the golden treasure present in algae to act against different cancers, this review highlights the potential use of algae as anticancer agents.

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Effect of ultrasonic treatment on the degradation and inhibition cancer cell lines of polysaccharides from Porphyra yezoensis

Cited by 103 publications

References 27 publications

Characterization, antioxidant and antitumor activities of polysaccharides from purple sweet potato

Characterization, antioxidant and antitumor activities of polysaccharides from purple sweet potato

Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root

Algae as potential repository of anti cancerous natural compounds

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