Effect of ultrasound on binding interaction between emodin and micellar casein and its microencapsulation at various temperatures

Min, Yang; Wei, Yanming; Ashokkumar, Muthupandian; Qin, Juanjuan; Han, Na; Wang, Yucheng

doi:10.1016/j.ultsonch.2019.104861

Cited by 46 publications

(49 citation statements)

References 38 publications

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“…Comparably, the main interaction forces between tea polyphenols, rutin, and β-LG at neutral pH were dominated by hydrophobic interactions, which is similar to our results [2] , [9] . These data collaborated well with previous data showing that ultrasound may strengthen or weaken the interactions between dietary protein and phenolics, but would not alter the type of major driving forces [38] . Overall, ULG-35 showed the highest K a and ΔH values when interacting with EGCG/CA, thus was selected in the following experiments.…”

Section: Resultssupporting

confidence: 90%

“…Ultrasound pre-treatment was beneficial for the hydrophobic stacking interactions between β-LG and phenolics, and the form of β-LG (dimer/monomer) played a crucial role in the spatial structure of complexes due to the distinct binding locations [1] , [8] . A similar phenomenon of ultrasound-driven protein structural changes by phenolic binding was witnessed in EGCG/GA–egg white [5] and emodin–micellar casein systems [38] .…”

Section: Resultssupporting

confidence: 58%

“…Given this, it is expected that the sonication of proteins would have a profound impact on their subsequent interactions with phenolic ingredients. To our knowledge, only a few studies have investigated the role of ultrasound on protein–phenolic binding, such as emodin–micellar casein [38] , egg white–gallic acid (GA)/EGCG [5] , and myofibrillar protein–GA systems [22] . Despite extensive research on β-LG relating phenolic addition and ultrasound alone, no studies have yet focused on the ultrasound-driven changes in the interactions between β-LG and dietary phenolics, results of which would provide greater insights into the utilization of both techniques in the dairy products.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ultrasonic pre-treatment modifies the pH-dependent molecular interactions between β-lactoglobulin and dietary phenolics: Conformational structures and interfacial properties

Zhang

Cen

et al. 2021

Ultrasonics Sonochemistry

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Section: Resultssupporting

confidence: 90%

Section: Resultssupporting

confidence: 58%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrasonic pre-treatment modifies the pH-dependent molecular interactions between β-lactoglobulin and dietary phenolics: Conformational structures and interfacial properties

Zhang

Cen

et al. 2021

Ultrasonics Sonochemistry

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“…Crosslinking of casein micelles [110], was used to create casein nanoparticles using transglutaminase by pushing out micellar calcium phosphate. Recently, Yang and coworkers [134], investigated the microencapsulation of emodin, having antibacterial and potent antioxidant properties, in micellar casein by applying heat (25 • C, 30 • C, 37 • C) and ultrasound (20 kHz). Fluorescence evaluation revealed that the hydrophobic forces are the primary interaction between micellar casein and emodin while heating independent of ultrasounds.…”

Section: Researchers Cohen and Hahammentioning

confidence: 99%

Casein Micelles as an Emerging Delivery System for Bioactive Food Components

Sadiq

Gill

Chandrapala

2021

Foods

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Bioactive food components have potential health benefits but are highly susceptible for degradation under adverse conditions such as light, pH, temperature and oxygen. Furthermore, they are known to have poor solubilities, low stabilities and low bioavailabilities in the gastrointestinal tract. Hence, technologies that can retain, protect and enable their targeted delivery are significant to the food industry. Amongst these, microencapsulation of bioactives has emerged as a promising technology. The present review evaluates the potential use of casein micelles (CMs) as a bioactive delivery system. The review discusses in depth how physicochemical and techno-functional properties of CMs can be modified by secondary processing parameters in making them a choice for the delivery of food bioactives in functional foods. CMs are an assembly of four types of caseins, (αs1, αs2, β and κ casein) with calcium phosphate. They possess hydrophobic and hydrophilic properties that make them ideal for encapsulation of food bioactives. In addition, CMs have a self-assembling nature to incorporate bioactives, remarkable surface activity to stabilise emulsions and the ability to bind hydrophobic components when heated. Moreover, CMs can act as natural hydrogels to encapsulate minerals, bind with polymers to form nano capsules and possess pH swelling behaviour for targeted and controlled release of bioactives in the GI tract. Although numerous novel advancements of employing CMs as an effective delivery have been reported in recent years, more comprehensive studies are required to increase the understanding of how variation in structural properties of CMs be utilised to deliver bioactives with different physical, chemical and structural properties.

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“…11,12 Emodin is the major bioactive compound of R. officinale and has strong anti-inflammatory and antioxidant properties. 13 It has been reported that emodin notably suppresses the development of multiple diseases. 14,15 Additionally, it has previously been verified that emodin can relieve the progression of renal fibrosis.…”

Section: Introductionmentioning

confidence: 99%

<p>Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway</p>

Yang

Deng

et al. 2020

DDDT

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Background: Renal fibrosis is a frequently occurring type of chronic kidney disease that can cause end-stage renal disease. It has been verified that emodin or HGF can inhibit the development of renal fibrosis. However, the antifibrotic effect of emodin in combination with HGF remains unclear. Methods: Cell viability was detected with CCK8. Gene and protein expression in HK2 cells was detected by qRT-PCR and Western blot, respectively. Moreover, a unilateral ureteral obstruction-induced mouse model of renal fibrosis was established for investigating the antifibrotic effect of emodin in combination with HGF in vivo. Results: HGF notably increased the expression of collagen II in TGFβ-treated HK2 cells. In addition, HGF-induced increase in collagen II expression was further enhanced by emodin. In contrast, fibronectin, αSMA and Smad2 expression in TGFβ-stimulated HK2 cells was significantly inhibited by HGF and further decreased by combination treatment (emodin plus HGF). Moreover, we found that combination treatment exhibited better antifibrotic effects compared with emodin or HGF in vivo. Conclusion: These data demonstrated that emodin plus HGF exhibited better antifibrotic effects compared with emodin or HGF. As such, emodin in combination with HGF may serve as a new possibilty for treatment of renal fibrosis.

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Effect of ultrasound on binding interaction between emodin and micellar casein and its microencapsulation at various temperatures

Cited by 46 publications

References 38 publications

Ultrasonic pre-treatment modifies the pH-dependent molecular interactions between β-lactoglobulin and dietary phenolics: Conformational structures and interfacial properties

Ultrasonic pre-treatment modifies the pH-dependent molecular interactions between β-lactoglobulin and dietary phenolics: Conformational structures and interfacial properties

Casein Micelles as an Emerging Delivery System for Bioactive Food Components

<p>Emodin Retarded Renal Fibrosis Through Regulating HGF and TGFβ–Smad Signaling Pathway</p>

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