Effect of ultrasound on development. Part 2: Studies in mammalian species and overview.

Sikov, M.R.

doi:10.7863/jum.1986.5.11.651

Cited by 24 publications

(4 citation statements)

References 10 publications

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“…In lieu of an earlier report of migrational aberration in mouse neocortex following prenatal exposure, as well as the healing effects ultrasound is known to have on bone fractures and varicose ulcers, we decided to delve further into the molecular biology of ultrasound [124, 125, 126]. While earlier animal studies utilized gross morphometry and evidence of tissue necrosis to establish safety levels, fewer studies have focused on ultrasound effects at the single cell level ([127] for review). Upon review of the literature, we found that ultrasound targets multipotent cell populations in particular.…”

Section: Targeting β-Catenin In Progenitor Proliferationmentioning

confidence: 99%

Above genetics: Lessons from cerebral development in autism

Williams

2011

Translational Neuroscience

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While a distinct minicolumnar phenotype seems to be an underlying factor in a significant portion of cases of autism, great attention is being paid not only to genetics but to epigenetic factors which may lead to development of the conditions. Here we discuss the indivisible role the molecular environment plays in cellular function, particularly the pivotal position which the transcription factor and adhesion molecule, β-catenin, occupies in cellular growth. In addition, the learning environment is not only integral to postnatal plasticity, but the prenatal environment plays a vital role during corticogenesis, neuritogenesis, and synaptogenesis as well. To illustrate these points in the case of autism, we review important findings in genetics studies (e.g., PTEN, TSC1/2, FMRP, MeCP2, Neurexin-Neuroligin) and known epigenetic factors (e.g., valproic acid, estrogen, immune system, ultrasound) which may predispose towards the minicolumnar and connectivity patterns seen in the conditions, showing how one-gene mutational syndromes and exposure to certain CNS teratogens may ultimately lead to comparable phenotypes. This in turn may shed greater light on how environment and complex genetics combinatorially give rise to a heterogenetic group of conditions such as autism.

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Section: Targeting β-Catenin In Progenitor Proliferationmentioning

confidence: 99%

Above genetics: Lessons from cerebral development in autism

Williams

2011

Translational Neuroscience

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“…In addition to the thermal effect of ultrasound, pulsed and continuous-wave ultrasound can affect reproduction and prenatal development of the embryo and fetus (Jensh and Brent 1999;Sikov 1986). Notable ultrasound effects such as increased malformation rates and weight changes have been observed in some studies, whereas others do not report any firm exposure-related effects in either dam or child (Brown et al 2004;Carnes et al 1991;Devi et al 1995;Fisher et al 1994Fisher et al , 1996Gu et al 2002;Devi 1992, 1995;Jia et al 2005;Karag€ oz et al 2007;Norton et al 1991;Oh et al 1999;Ryo et al 2001;Tarantal et al 1993).…”

Section: Prenatal Exposure To Ultrasoundmentioning

confidence: 99%

Mechanical and Biological Effects of Ultrasound: A Review of Present Knowledge

Izadifar

Babyn

Chapman

2017

Ultrasound in Medicine & Biology

214

127

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Ultrasound is widely used for medical diagnosis and increasingly for therapeutic purposes. An understanding of the bio-effects of sonography is important for clinicians and scientists working in the field because permanent damage to biological tissues can occur at high levels of exposure. Here the underlying principles of thermal mechanisms and the physical interactions of ultrasound with biological tissues are reviewed. Adverse health effects derived from cellular studies, animal studies and clinical reports are reviewed to provide insight into the in vitro and in vivo bio-effects of ultrasound.

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“…Hence, any external disruption like ultrasound heating could possibly affect the development of the glands, thus its secretion (Dom et al, 2013). There are two basic mechanisms, thermal and non-thermal, by which ultrasound is known to affect biologic materials (Ndumbe et al, 2008;Sheiner & Abramowicz 2008;Brendt, 1986;Sikov, 1986a;Sikov, 1986b;Laurel, 1993). The thermal mechanism is associated with the absorption of acoustic energy by tissue and the generation of heat.…”

Section: Introductionmentioning

confidence: 99%

Effect of multiple in-utero insonation on rabbit fetal thyroid hormonal level

Idris¹,

Audu²,

Fadason³

et al. 2017

Sokoto J. Vet. Sc.

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Due to the increased use of ultrasound in the diagnosis of cyesis, it is necessary to study the possible adverse effect of insonation on thyroid hormone in fetuses. Sixteen (16) adult rabbit does that had kindled at least once were used for the study and were scanned using a Medison S600V ® Ultrasound machine with a 6.5MHz transcutaneous curve-linear probe. All does were mated naturally by the introduction of a doe to a buck and then divided randomly into two groups. The does that were scanned (insonated)-, were properly restrained on dorsal recumbency, liberally shaved; aquasonic gel applied and scanned using a transcutaneous curve-linear probe for 5 minutes on the 5 th day post coitus and thereafter on days 7, 12, 15, 20, 25, 27 and 29. The restrain and scanning procedures were mimicked on the group of does that were not scanned (non-insonated). Upon parturition, blood was collected from kits and serum was extracted and used to assay for total thyroxine (tT4) and triiodothyronine (tT3). Fetal thyroid glands were also harvested for histologic study. Mean tT3 concentration was 1.60 ± 0.90 µg/dl and 1.58 ± 0.03 µg/dl while mean tT4 was 1.46 ± 0.10 µg/dl and 1.39 ± 0.07 µg/dl for the non-insonated and insonated groups, respectively. P values of 0.610 and 0.132 for tT3 and tT4 concentration respectively showed that there is no statistically significant difference in the values even though there was a numerical difference between the groups. No histopathologic change on fetal thyroid gland from both groups was observed. In conclusion, although the values were not significantly different, the numerical decrease of both tT3 and tT4 in the insonated rabbits suggest the possibility that insonation could alter their values in fetuses when the threshold of ultrasound waves are increased and insonation prolonged.

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Effect of ultrasound on development. Part 2: Studies in mammalian species and overview.

Cited by 24 publications

References 10 publications

Above genetics: Lessons from cerebral development in autism

Above genetics: Lessons from cerebral development in autism

Mechanical and Biological Effects of Ultrasound: A Review of Present Knowledge

Effect of multiple in-utero insonation on rabbit fetal thyroid hormonal level

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