Effect of Ultraviolet-A and Riboflavin treatment on the architecture of the center and periphery of normal rat cornea: 7 days post treatment

Akhtar, Saeed; Smędowski, Adrian; Masmali, Ali M.; Alkanaan, Aljoharah; Khan, Adnan; Almutleb, Essam S.; mofty, hanan; Al-Debasi, Hind I; Samivel, Ramachandran; Almubrad, Turki

doi:10.1016/j.exer.2022.109064

Experimental Eye Research

2022

DOI: 10.1016/j.exer.2022.109064

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Effect of Ultraviolet-A and Riboflavin treatment on the architecture of the center and periphery of normal rat cornea: 7 days post treatment

Saeed Akhtar

Adrian Smędowski

Ali M. Masmali

et al.

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Cited by 3 publications

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“… 7 This reaction promotes the formation of chemical crosslinks within collagen fibrils and between surrounding proteoglycans that are highly abundant within the stroma. 8 Physiologically crosslinking by lysyl oxidase or age-related glycation end products during prolonged hyperglycemia are slow reactions by comparison that likewise influence the biomechanical properties of the cornea and have been inversely associated with the development of KC. 9 …”

mentioning

confidence: 99%

Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus

Van

Bennett

Nicholas

et al. 2024

Ophthalmology Science

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mentioning

confidence: 99%

Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus

Van

Bennett

Nicholas

et al. 2024

Ophthalmology Science

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Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography

Regnault,

Kirby,

Wang

et al. 2023

Biomed. Opt. Express

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Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking mechanical wave propagation, depth dependent changes are still unclear if the cornea is not crosslinked through the whole depth. Here, phase-decorrelation measurements on optical coherence tomography (OCT) structural images are combined with acoustic micro-tapping (AµT) OCE to explore possible reconstruction of depth-dependent stiffness within crosslinked corneas in an ex vivo human cornea sample. Experimental OCT images are analyzed to define the penetration depth of CXL into the cornea. In a representative ex vivo human cornea sample, crosslinking depth varied from ∼100 µm in the periphery to ∼150 µm in the cornea center and exhibited a sharp in-depth transition between crosslinked and untreated areas. This information was used in an analytical two-layer guided wave propagation model to quantify the stiffness of the treated layer. We also discuss how the elastic moduli of partially CXL-treated cornea layers reflect the effective engineering stiffness of the entire cornea to properly quantify corneal deformation.

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The Results of Experimental Studies of the Passage of Light Energy Under the Skin of Animals Along Individual Hairs

Сhervinsky¹,

Radko²,

Nalyvaiko³

et al. 2022

Tehnìka ta energetika

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This paper presents new scientific results of experimental studies that refute the generally accepted fact that the coat solely protects animals from the effects of solar energy. The purpose of this study was to confirm the fact of the spread of optical radiation energy under the animal’s skin along individual hairs, as light guides. The authors of this study experimentally determined the optically conductive structure of an individual wool hair, the components of the transmission parameter of an individual wool hair, namely the coefficient of light transmission inside the wool hair, the coefficient of attenuation of internal light transmission by the substance of the wool hair, the coefficient of losses in the middle of the cylinder of the wool hair due to the beam scattered in the internal structure and the refractive index of its outer shell. Based on the use of methods of photometry and geometric optics, theoretically substantiated and experimentally obtained results regarding the establishment of a mathematical dependence of the total amount of optical radiation energy entering the hair cylinder on the value of the angle of incidence of the beam on the surface of the hair, the cleanliness of the inner core of the cylinder structure, the length of the light-conducting section to the surface of the skin, as well as the refractive index of its outer shell. Based on the results of experimental studies, mathematical dependencies were obtained that describe the spectral light-conducting properties of an individual hair, as well as the distribution of energy emitted in the thickness of the skin along the entire length from the point of penetration into the hair and to the follicle – the place of use of optical energy in photobiological processes. The obtained results of experimental studies of the passage of optical radiation energy along the length of a single hair into the body of an animal are of practical importance for photobiologists investigating the effect of optical radiation from the Sun on biological objects of animal origin.

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Effect of Ultraviolet-A and Riboflavin treatment on the architecture of the center and periphery of normal rat cornea: 7 days post treatment

Cited by 3 publications

References 29 publications

Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus

Prospective Observational Study Evaluating Systemic Hormones and Corneal Crosslinking Effects in Keratoconus

Possible depth-resolved reconstruction of shear moduli in the cornea following collagen crosslinking (CXL) with optical coherence tomography and elastography

The Results of Experimental Studies of the Passage of Light Energy Under the Skin of Animals Along Individual Hairs

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