Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells

Ryšavá, Alena; Vostalová, Jitka; Svobodová, Alena Rajnochová

doi:10.1080/09553002.2021.1962566

Cited by 38 publications

(30 citation statements)

References 185 publications

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“…These external stimuli also lead to an increase in the phosphorylation of the MAPK family such as extracellular signal-regulated kinase (ERK), c-jun N -terminal kinase (JNK), and p38, which then affects the phosphorylation of nuclear transcription factor AP-1 (c-Jun, c-Fos), which contributes to express MMPs [ 3 , 6 , 8 ]. On the contrary, many cells including dermal fibroblasts have a system to defend ROS called the nuclear factor erythroid-2-related factor 2 (NRF2) signaling pathway [ 17 ]. This pathway accelerates the expression levels of genes that regulate processes such as protein stability, autophagy, senescence, and protection against oxidative stress and inflammation.…”

Section: Resultsmentioning

confidence: 99%

The Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts

2022

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Skin is the largest organ in the body comprised of three different layers including the epidermis, dermis, and hypodermis. The dermis is mainly composed of dermal fibroblasts and extracellular matrix (ECM), such as collagen and elastin, which are strongly related to skin elasticity and firmness. Skin is continuously exposed to different kinds of environmental stimuli. For example, ultraviolet (UV) radiation, air pollutants, or smoking aggravates skin aging. These external stimuli accelerate the aging process by reactive oxygen species (ROS)-mediated signaling pathways and even cause aging-related diseases. Skin aging is characterized by elasticity loss, wrinkle formation, a reduced dermal-epidermal junction, and delayed wound healing. Thus, many studies have shown that natural polyphenol compounds can delay the aging process by regulating age-related signaling pathways in aged dermal fibroblasts. This review first highlights the relationship between aging and its related molecular mechanisms. Then, we discuss the function and underlying mechanism of various polyphenols for improving skin aging. This study may provide essential insights for developing functional cosmetics and future clinical applications.

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Section: Resultsmentioning

confidence: 99%

The Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts

2022

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“…CA attenuates the local immune repression provoked via UVB irradiation and blocks the UVB-irradiation-mediated IL-10 promoter, IL-10 mRNA expression, and protein-making in mouse skin ( 178 , 180 ). CA can present IL-10-making by interfering with prostaglandin E2 production connected to stimulating the UVB-irradiation-mediated immune repressive cytokine system.…”

Section: Anticancer Effect Of Caffeic Acidmentioning

confidence: 99%

Therapeutic Implications of Caffeic Acid in Cancer and Neurological Diseases

et al. 2022

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Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA and its derivatives have been used for many centuries due to their natural healing and medicinal properties. CA possesses various biological and pharmacological activities, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. The potential therapeutic effects of CA are mediated via repression and inhibition of transcription and growth factors. CA possesses potential anticancer and neuroprotective effects in human cell cultures and animal models. However, the biomolecular interactions and pathways of CA have been described highlighting the target binding proteins and signaling molecules. The current review focuses on CA’s chemical, physical, and pharmacological properties, including antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. We further described CA’s characteristics and therapeutic potential and its future directions.

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“…concluded that keratinocytes show a less prominent response to UVA radiation for NRF2 translocation and NRF2-controlled proteins (HO-1, NQO1, GSR, GST, IL-6, and MMP-1, MMP-2), compared to primary human fibroblasts [ 137 ]. In a review by Ryšavá et al the effect of UVR on the NRF2 signaling pathway in skin cells is well described [ 138 ].…”

Section: Photoprotective Action Of the Nrf2 System In The Skinmentioning

confidence: 99%