Systemic lupus erythematosus in children is a multisystem disease with extensive organ involvement. Mothers may struggle to manage their child's health, their own emotions and had negative effect on mothers quality of life and self-efficacy. The aim of the study: Was to evaluate effect of family empowerment model on quality of life and self-efficacy of mothers toward children with systematic lupus. Research design: A quasi-experimental (pre/post-test) design.