Effect of Uremia on Semen Quality and Reproductive Function in Humans

Li-qun, XU; Xu, Huiming; Zhu, Xiaofeng; Junrong, Zhang; Ma, Mingzhe; Shi, Xiaohong

doi:10.1007/s12013-011-9254-9

Cited by 11 publications

(11 citation statements)

References 11 publications

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“…Kosar et al The explanation of the decrease in mean ST levels in unhealthy men in sub/infertility studies are not well known, but it is hypothesized that it is due to the action of interleukin-6 (IL6) in testis to reduces transferrin secretion in Sertoli cells (15). All sperm cell parameters evaluated (Table 1) were significantly lower in the case group than in the control group (p = 0.000), corroborating partially the results of other authors (16,17) that did not found significant differences for all the elements of the SP (16,17). However there is a study that did not show a significant difference in ST levels between healthy subjects and those with seminal quality alterations (18).…”

Section: Discussionsupporting

confidence: 76%

Seminal transferrin in the seminal quality evaluation of hemodialytic patients

Silva

Carneiro

Grangeiro

2018

Arch Ital Urol Androl

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Section: Discussionsupporting

confidence: 76%

Seminal transferrin in the seminal quality evaluation of hemodialytic patients

Silva

Carneiro

Grangeiro

2018

Arch Ital Urol Androl

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“…Xu et al (16) found similar results in a uremic population: 0.68 (2.08) for case and 7.7 (13.51) for control.…”

Section: Discussionmentioning

confidence: 55%

“…After the contribution of uremic factor in the lowering of seminal quality in patients with renal failure was recognized (16,20), the contribution of the oxidative/inflammatory factors was emphasized (21,22). Patients undergoing hemodialysis can be characterized by increased levels of oxidative stress and inflammation (23).…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammation and Seminal Parameters in Chronic Hemodialysis Patients

2018

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Objectives: We proposed to investigate the possible effect and association of systemic inflammation (SI) and seminal parameter indicators in chronic hemodialysis patients. Methods: This was a case-control study. All the participants were subjected to a spermiogram with calculation of fertility index (FI), serum C-reactive protein (CRP) level, seminal transferrin (ST) level, as well as evaluation of the hormonal profile (HP). The sample consisting of 60 men (cases) undergoing hemodialysis for more than 6 months was subdivided into 3 groups: group 1 (n = 30, with inflammation, CRP > 5 mg/L), group 2 (n = 30, without inflammation, CRP ≤ 5 mg/L), and group 3 (n = 30, healthy men, CRP ≤ 1). Results:Age was similar in the 3 groups (P = 0.43). FI, testosterone total (TT) and ST levels were significantly lower in the case groups than in the control group (P < 0.001). Follicle stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL) levels were significantly higher in the case groups than in the control group (P < 0.001). Between the subgroups of cases (groups 1 and 2), the inflammatory factor alone does not seem to interfere with the FI, HP, and ST level (P > 0.05). However, it significantly interfered with the FI, HP, and ST level when compared between the case groups and the control group (P < 0.001). No correlation was observed between SI and analyzed parameters (P > 0.05). Conclusions:The results suggest that the SI alone has no effect and is not associated with the FI or ST level in a patient undergoing chronic hemodialysis.

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“…Changes to the function of the hypothalamic-pituitary-ovarian/testis axis in patients with chronic renal failure or severe hepatic dysfunction may result in anovulation or azoospermia. Uremia causes a significant decline in reproductive function and sperm quality which may lead to infertility or even sterility in humans (7). The earlier the onset, pre or post-pubertal, and the longer the duration of uremia, the more impairment the reproductive function in the human (8).…”

Section: Discussionmentioning

confidence: 99%

Intracytoplasmic sperm injection in male renal transplant recipients

Berkkanoğlu

Bulut

Coetzee

et al. 2015

Middle East Fertility Society Journal

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Objective: In this study, we reviewed the reproductive outcomes following ICSI in 5 couples where the male partners had undergone renal transplantations. Chronic renal failure and dialysis may adversely affect male reproductive function resulting in severely depressed semen parameters or even azoospermia, which maybe further adversely affected by the immunosuppression taken from after transplantation.Study design: Case report. Setting: A private fertility clinic. Patients: The study included five infertile couples where the male partners were the recipients of renal transplants, 3-15 years prior to having ICSI treatment. All couples suffered from male factor infertility, with diagnoses of; azoospermia, asthenoteratozoospermia, oligoasthenoteratozoopsermia.Results: In the 5 case reports 5 ICSI and 3 FET treatment procedures were completed. In all but one of the cases grade 1 quality embryos were obtained and transferred. From the 8 embryo transfers performed 4 pregnancies were obtained, one miscarried at 8 weeks and 3 resulted in live births.

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Effect of Uremia on Semen Quality and Reproductive Function in Humans

Cited by 11 publications

References 11 publications

Seminal transferrin in the seminal quality evaluation of hemodialytic patients

Seminal transferrin in the seminal quality evaluation of hemodialytic patients

Systemic Inflammation and Seminal Parameters in Chronic Hemodialysis Patients

Intracytoplasmic sperm injection in male renal transplant recipients

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