Effect of Use of Propolis on Serum Levels of Il-17 and Clinical Symptoms and Signs in Patients with Ulcerative Oral Lichen Planus

Zenouz, Ali Taghavi; Mehdipour, Masoumeh; Abadi, Reza Tavakoli Ata; Shokri, Javad; Rajaee, Mehrangiz; Aghazadeh, Marziyeh; Golizadeh, Narges

doi:10.1016/j.oooo.2014.07.285

Cited by 4 publications

(9 citation statements)

References 14 publications

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“…Such variations in effect vs. composition across different samples could provide the basis for a subsequent study. The effects of propolis on the immune response are very interesting, and these in vitro results support the in vivo trials [ 10 , 11 , 12 , 13 ] aimed at producing immune modulation. There is a particularly strong need for a more comprehensive study of the absorption and metabolism of propolis components to support any claims with regard to its efficacy in providing immune support.…”

Section: Discussionsupporting

confidence: 59%

“…The current paper provides strong support for propolis being effective as an anti-inflammatory complex. Propolis has been studied as an immunomodulatory agent in a number of sizeable trials, and its safety in high doses is good [ 9 , 10 , 11 , 12 , 13 ]. There had been no studies examining whether or not the components in propolis are absorbed.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent paper, we studied several types of propolis for their effects on the metabolic response of THP-1 cells to treatment with lipopolysaccharide (LPS), and for one sample from Cameroon, which inhibited cytokine release, we studied the metabolomics of the immune response and found a clear effect of the propolis in inhibiting purine nucleotide phosphorylase [ 8 ]. In addition, there have been some quite extensive trials of propolis in humans aimed at affecting the immune response [ 9 , 10 , 11 , 12 , 13 ]. The commonly available propolis supplements, such as glycerol-based tinctures, lozenges, and capsules, are mainly based on temperate propolis such as that collected by bees in the UK.…”

Section: Introductionmentioning

confidence: 99%

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Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages

Alanazi

Alenzi

Fearnley³

et al. 2020

Metabolites

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Previous research has shown that propolis has immunomodulatory activity. Extracts from two UK propolis samples were assessed for their anti-inflammatory activities by investigating their ability to alter the production of the cytokines: tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-10 from mouse bone marrow-derived macrophages co-stimulated with lipopolysaccharide (LPS). The propolis extracts suppressed the secretion of IL-1β and IL-6 with less effect on TNFα. In addition, propolis reduced the levels of nitric oxide formed by LPS-stimulated macrophages. Metabolomic profiling was carried out by liquid chromatography (LC) coupled with mass spectrometry (MS) on a ZIC-pHILIC column. LPS increased the levels of intermediates involved in nitric oxide biosynthesis; propolis lowered many of these. In addition, LPS produced an increase in itaconate and citrate, and propolis treatment increased itaconate still further while greatly reducing citrate levels. Moreover, LPS treatment increased levels of glutathione (GSH) and intermediates in its biosynthesis, while propolis treatment boosted these still further. In addition, propolis treatment greatly increased levels of uridine diphosphate (UDP)–sugar conjugates. Overall, the results showed that propolis extracts exert an anti-inflammatory effect by the inhibition of pro-inflammatory cytokines and by the metabolic reprogramming of LPS activity in macrophages.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages

Alanazi

Alenzi

Fearnley³

et al. 2020

Metabolites

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“…They also proved that propolis showed to be a promising pharmacological agent for inhibiting epithelial cell proliferation and has anti-inflammatory effect. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

To evaluate the efficacy of topical propolis in the management of symptomatic oral lichen planus: A randomized controlled trial

et al. 2018

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“…Eleven studies used the ethanolic extract of propolis, two used aqueous extract (2), one used ethyl alcoholic, and one used hydroalcoholic solution (1). All studies reported the origin of the propolis used, except three studies [18,34,35].…”

Section: Study Characteristicsmentioning

confidence: 99%

Propolis Controlled Delivery Systems for Oral Therapeutics in Dental Medicine: A Systematic Review

et al. 2023

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This systematic review synthesizes the existing evidence in the literature regarding the association of propolis with controlled delivery systems (DDSs) and its potential therapeutic action in dental medicine. Two independent reviewers performed a literature search up to 1 June 2023 in five databases: PubMed/Medline, Web of Science, Cochrane Library, Scopus, and Embase, to identify the eligible studies. Clinical, in situ, and in vitro studies that investigated the incorporation of propolis as the main agent in DDSs for dental medicine were included in this study. Review articles, clinical cases, theses, dissertations, conference abstracts, and studies that had no application in dentistry were excluded. A total of 2019 records were initially identified. After carefully examining 21 full-text articles, 12 in vitro studies, 4 clinical, 1 animal model, and 3 in vivo and in vitro studies were included (n = 21). Relevant data were extracted from the included studies and analyzed qualitatively. The use of propolis has been reported in cariology, endodontics, periodontics, stomatology, and dental implants. Propolis has shown non-cytotoxic, osteoinductive, antimicrobial, and anti-inflammatory properties. Moreover, propolis can be released from DDS for prolonged periods, presenting biocompatibility, safety, and potential advantage for applications in dental medicine.

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Effect of Use of Propolis on Serum Levels of Il-17 and Clinical Symptoms and Signs in Patients with Ulcerative Oral Lichen Planus

Cited by 4 publications

References 14 publications

Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages

Temperate Propolis Has Anti-Inflammatory Effects and Is a Potent Inhibitor of Nitric Oxide Formation in Macrophages

To evaluate the efficacy of topical propolis in the management of symptomatic oral lichen planus: A randomized controlled trial

Propolis Controlled Delivery Systems for Oral Therapeutics in Dental Medicine: A Systematic Review

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