Effect of vaccination against gonadotropin-releasing factor (GnRF) with Bopriva® in the prepubertal bull calf

Janett, F.; Gerig, Thomas M.; Tschuor, A; Amatayakul-Chantler, S.; Walker, John; Howard, R.; Marion, P; Bollwein, Heinrich; Hartnack, Sonja; Thun, R.

doi:10.1016/j.anireprosci.2012.02.012

Cited by 33 publications

(31 citation statements)

References 51 publications

(75 reference statements)

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“…At the end of the study, 20 weeks after the second vaccination, the difference between vaccinated and control animals was still 9 cm. The observation that vaccination against GnRF resulted in an impairment of testicular development was also found in previous studies in pubertal [4,13] as well as prepubertal [6,20] bulls. In the pilot experiment [13] using Bopriva ® , calves were slaughtered 3 months after the booster vaccination and histological examination of testes performed.…”

Section: Daysupporting

confidence: 84%

“…When comparing these data with a recent experiment [20] using bull calves vaccinated at an early age of 3 to 6 weeks, mean maximum titer concentration and the duration of testosterone suppression in the older bulls were reduced by approximately half.…”

Section: Daymentioning

confidence: 66%

“…Currently Bopriva  is the only anti-GnRF vaccine available for cattle on the market and has demonstrated good efficacy and safety in a pilot project [13] with young bulls. The latter and several other studies [6,9,20,40,41] have shown that anti-GnRF based vaccines to be efficacious at suppressing testosterone driven sexual and aggressive behavior. In these investigations behavior was only assessed subjectively but no information is available in the literature about behavior changes in vaccinated bulls analyzed objectively by using an electronic activity meter system.…”

Section: Introductionmentioning

confidence: 75%

“…As it has been shown in many investigations published during the last years [3][4][5][6][7][8][9][10]17,20,[29][30][31][32][33][34] vaccination against GnRF was able to induce an increase in anti-GnRF antibody titer.…”

Section: Discussionmentioning

confidence: 99%

“…The suppression of reproductive function using an anti-GnRF vaccine has been demonstrated in numerous studies in cattle [3][4][5][6][7][8][9][10][11][12][13], sheep [10,[14][15][16][17][18][19][20][21], pig [22][23][24][25][26][27][28], horse [29][30][31][32][33][34] and in wild animals [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

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Vaccination against gonadotropin-releasing factor (GnRF) with Bopriva significantly decreases testicular development, serum testosterone levels and physical activity in pubertal bulls

Janett

Gerig

Tschuor³

et al. 2012

Theriogenology

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The aim of this study was to evaluate the effects of vaccination against gonadotropin-releasing factor (GnRF) on testicular development, testosterone secretion, and physical activity in pubertal bulls. The experiment was performed using 44 bulls aged between 6 and 7 mo. Twenty-three animals were vaccinated twice 4 wk apart with 1 mL of Bopriva (Pfizer, Animal Health, Parkville, Australia) and 21 bulls served as matched controls. Serum GnRF antibody titer and testosterone concentration as well as body weight and scrotal circumference were determined in all bulls for 24 wk from the first vaccination. In addition, physical activity was analyzed in 11 vaccinated and in 10 control animals using the ALPRO DeLaval activity meter system (DeLaval AG, Sursee, Switzerland). The results show that vaccination significantly (P < 0.05) influenced all parameters evaluated except body weight. Antibody titers to GnRF began to rise 2 wk after the first vaccination and reached peak values 2 wk after the second injection. Significant group differences in anti-GnRF titer were present for 22 wk following the first vaccination. Testosterone concentrations were significantly lower between weeks 6 to 24 after first vaccination in bulls with Bopriva compared with control animals. In vaccinated bulls testicular development was impaired after the second injection and scrotal circumference was significantly smaller between weeks 8 to 24 after first vaccination. Physical activity of vaccinated bulls was reduced after the booster injection with significant group differences for a continuous period of 106 days. In conclusion, vaccination against GnRF with Bopriva in pubertal bulls decreased testosterone levels in peripheral blood, testicular development, and physical activity but did not affect weight gain. AbstractThe aim of this study was to evaluate the effects of vaccination against gonadotropinreleasing factor (GnRF) on testicular development, testosterone secretion and physical activity in pubertal bulls. The experiment was performed using 44 bulls aged between 6 and 7 months. Twenty-three animals were vaccinated twice 4 weeks apart with 1 mL of Bopriva ® (Pfizer Animal Health, Australia) and 21 bulls served as matched controls. Serum GnRF antibody titer and testosterone concentration as well as body weight and scrotal circumference were determined in all bulls for 24 weeks from the first vaccination. In addition, physical activity was analyzed in 11 vaccinated and in 10 control animals using the ALPRO  DeLaval activity meter system (DeLaval AG, Sursee, Switzerland). The results show that vaccination significantly (P < 0.05) influenced all parameters evaluated except body weight. Antibody 2 titers to GnRF began to rise 2 weeks after the first vaccination and reached peak values 2 weeks after the second injection. Significant group differences in anti-GnRF titer were present for 22 weeks following the first vaccination. Testosterone concentrations were significantly lower between weeks 6 to 24 after first vaccination in bulls w...

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