Effect of vaccination in lowering the prevalence of bovine brucellosis in the State of Mato Grosso, Brazil

Barddal, Janice Elena Ioris; Quixabeira-Santos, Jociane Cristina; Lopes, Isabela Ferreira; Neto, José Soares Ferreira; Ferreira, Fernando; Amaku, Marcos; Dias, Ricardo Augusto; Telles, Evelise Oliveira; Grisi-Filho, José Henrique Hildebrand; Heinemann, Marcos Bryan; Gonçalves, Vı́tor Salvador Picão; Aguiar, Daniel Moura de

doi:10.5433/1679-0359.2016v37n5supl2p3479

Cited by 30 publications

(41 citation statements)

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“…However, a decrease in the prevalence of infected herds was found only in Mato Grosso, Mato Grosso do Sul, Minas Gerais and Rondônia (BARDDAL et al, 2016;ANZAI et al, 2016;INLAMEA et al, 2016;LEAL FILHO et al, 2016;OLIVEIRA et al, 2016;. The state of Santa Catarina, which had exhibited the lowest prevalence of infected herds and animals, had prohibited the vaccination and had, instead, implemented eradication strategies.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling of bovine brucellosis control using the RB51 vaccine

Souza

Neto

Amaku

et al. 2016

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The Brazilian Ministry of Agriculture, Livestock and Food Supply established the National Program for Control and Eradication of Brucellosis and Tuberculosis (PNCEBT) in 2001. One of the main strategies adopted by the program is the mandatory vaccination of heifers between three and eight months of age with the B19 strain. In 2007, Brazil allowed the use of RB51 vaccine in bovine females over 8 months of age as an option for the producer, but kept the B19 strain as a mandatory vaccine. This decision is based on the assumption that combining the two vaccines allows to achieve significant vaccination coverage sooner and, consequently, accelerates the fall speed of prevalence. Thus, this study aimed to measure the impact of the combined use of these two vaccines in reducing the prevalence, using as a tool the mathematical modeling. It was concluded that vaccination by RB51, if adopted as a complement to vaccination by B19, mean decrease in the prevalence of bovine brucellosis in less time. Key words: Bovine brucellosis. Thematical modeling. Vaccine. B19. RB51. ResumoO Ministério da Agricultura Pecuária e Abastecimento brasileiro instituiu o Programa Nacional de Controle e Erradicação da Brucelose e da Tuberculose Animal em 2001. Uma das principais medidas adotadas pelo programa é a vacinação obrigatória de fêmeas entre três e oito meses de idade com a cepa B19. Em 2007, o Brasil permitiu a utilização da vacina RB51 em fêmeas bovinas com mais de 8 anos de idade como uma opção para o produtor, porém manteve como vacina obrigatória a B19 em bezerras de 3 a 8 meses de idade. Essa decisão parte do princípio de que combinando as duas vacinas abrevia-se o tempo para a obtenção de coberturas vacinais expressivas na população de fêmeas em idade de procriar e, consequentemente, acelera-se a velocidade de queda da prevalência. Assim, o presente estudo objetivou medir o impacto do uso combinado dessas duas vacinas na redução da prevalência, utilizando como instrumento a modelagem matemática. Concluiu-se que a vacinação pela RB51, se adotada de forma complementar à vacinação pela B19, significaria queda da prevalência da brucelose bovina em menor intervalo de tempo. Palavras-chave: Brucelose bovina. Modelagem matemática. Vacina. B19. RB51

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Section: Introductionmentioning

confidence: 99%

Mathematical modeling of bovine brucellosis control using the RB51 vaccine

Souza

Neto

Amaku

et al. 2016

SCA

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“…The states of Santa Catarina, São Paulo, Minas Gerais, Rondônia, Mato Grosso, Mato Grosso do Sul, and Rio Grande do Sul carried out a second study on the prevalence of brucellosis. Of the 7 states included in this study a decrease in the prevalence of infected herds, as a consequence of the immunization program, was observed only in the states of Mato Grosso, Mato Grosso do Sul, Minas Gerais, and Rondônia (BARDDAL et al;BAUMGARTEN et al, 2016;DIAS et al, 2016;INLAMEA et al, 2016;LEAL FILHO et al, 2016;OLIVEIRA et al, 2016;SILVA et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

An update on the epidemiologic situation of bovine brucellosis in the State of Espírito Santo, Brazil

Anzai

Costa²,

Said

et al. 2016

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A cross-sectional study was carried out between January 2012 and May 2014 to estimate the prevalence of bovine brucellosis in the state of Espírito Santo, Brazil. This study was carried out 11 years after the implementation of the immunization program for heifers with a vaccine derived from the S19 strain of Brucella abortus. The state was divided into two regions. Three hundred farms from each region, with reproductive activity, were randomly chosen and included as primary sample units. A fixed number of cows were randomly selected and tested for antibodies against Brucella spp. A farm was considered to be infected when at least one female tested positive for Brucella spp. In the selected farms, an epidemiological questionnaire based survey, focused on herd traits as well as husbandry and sanitary practices, was conducted, to evaluate the factors associated with the risk of infection. The overall prevalence of infected herds was 9.3% (95% confidence interval, 95% CI = 7.1-11.8%), varying from 8.7% (95% CI = 5.7-12.6%) in region 2 to 9.7% (95% CI = 6.8-13.4%) in region 1. There was no significant difference in the prevalence between the regions. The apparent prevalence of Brucella spp. positive farms across the regions and the state was similar to the prevalence observed 11 years earlier.The prevalence of positive animals was 3.8% (95% CI = 0.9-10.1%), varying from 1.5% (95% CI = 0.8-2.4%) in region 1 to 7.9% (95% CI = 1.9-20.3%) in region 2, without a significant difference between the regions. There was no difference in the number of Brucella spp. positive animals after 11 years of the immunization program. The risk factors associated with brucellosis were (i) more than 10 cows per herd (OR = 5.0; 95% CI =2.5-11.1) and (ii) equipment, feedstock, or personnel sharing (OR = 2.2; 95% CI = 1.1-4.2). The state of Espírito Santo should seek systematic vaccination coverage targeting more than 80% of the eligible heifers. An efficient animal health program, which educates the farmers to test replacement animals for brucellosis before introducing them to their herds, to avoid equipment, personnel or feedstock sharing with farms of unknown sanitary conditions, and to increase awareness of the importance of good sanitary procedures during artificial insemination, should be implemented. Anzai, E. K. et al. ResumoPara estimar a prevalência e os fatores de risco da brucelose bovina no Estado do Espírito Santo (Brasil), foi realizado um estudo transversal entre janeiro de 2012 e maio de 2014. Esse estudo foi realizado 11 anos após a implementação de um programa de imunização em novilhas utilizando uma vacina derivada da estirpe S19 de Brucella abortus. O estado foi dividido em duas regiões. Trezentas propriedades com atividade reprodutiva foram aleatoriamente selecionadas em cada região e incluídas como unidades primárias de amostragem. Um número fixo de fêmeas adultas foi aleatoriamente selecionado em cada propriedade. Os animais foram testados para anticorpos contra Brucella spp. Um questionário epidemiológico foi ...

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“…The states of São Paulo, Minas Gerais, Espirito Santo, Rondônia, Mato Grosso, and Mato Grosso do Sul conducted a second brucellosis prevalence study in order to verify the effectiveness of their immunization programs. However, only in Mato Grosso, Mato Grosso do Sul, Minas Gerais, and Rondônia was a decrease in the prevalence of infected herds confirmed (BARDDAL et al, 2016;DIAS et al, 2016;ANZAI et al, 2016;INLAMEA et al, 2016;LEAL FILHO et al, 2016;OLIVEIRA et al, 2016). The state of Santa Catarina, which had the lowest prevalence of infected herds and animals, prohibited vaccinations and initiated the implementation of eradication strategies.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological situation of bovine brucellosis after implementation of a vaccination program in Rio Grande do Sul State, Brazil

Silva

Groff

Vidor

et al. 2016

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This study aimed to evaluate the effectiveness of a bovine brucellosis vaccination program in Rio Grande do Sul, with prevalence as the indicator, and to identify risk factors for the disease. The state was divided into seven regions. For each region, a predetermined number of properties were randomly sampled, in which a pre-established number of randomly selected females aged over 24 months were tested. The serodiagnosis protocol consisted of a screening test using buffered acidified antigen, followed by a confirmatory test using 2-mercaptoethanol. An epidemiological questionnaire was utilized to identify possible risk factors associated with bovine brucellosis. In the state of Rio Grande do Sul, the prevalence of infected herds was found to be 3.54% [2.49-4.88], and the prevalence of infected animals was 0.98% [0.57-1.57]. In assessments of specific regions, the infected herd prevalence ranged from 0.66% to 3.09%, and among the animals, from 0.06% to 2.03%. In herds comprising 15 or more cows, beef type and pasture sharing emerged as risk factors for bovine brucellosis in the state. The epidemiological status of bovine brucellosis in Rio Grande do Sul has remained unchanged since 2004, even though adequate vaccination coverage has been recorded since 2009. Thus, the state should continue its vaccination program, with emphasis on the quality of the process and on encouraging the use of nonantibody inducing vaccines. In addition, the state must make a greater effort to educate producers on the importance of testing for brucellosis in breeding animals before introducing them onto their properties, and on the importance of avoiding shared grazing among herds whose health conditions are unknown. preestabelecido de propriedades nas quais foi testado um número também preestabelecido de fêmeas com idade igual ou superior a 24 meses, aleatoriamente selecionadas. O protocolo do sorodiagnóstico foi composto de triagem com o teste do antígeno acidificado tamponado, seguido de teste confirmatório dos positivos com o teste 2-Mercaptoetanol. Nas propriedades foi aplicado um questionário epidemiológico sobre possíveis fatores de riscos associados à brucelose bovina. No estado do Rio Grande do Sul, a prevalência de focos foi de 3.54% [2.49 -4.88] e a de animais 0.98% [0.57 -1.57]. Nas regiões, as prevalências de focos variaram de 0.66% a 9.03% e a de animais de 0.06% a 2.03%. Rebanhos com 15 ou mais vacas, tipologia corte e compartilhamento de pastagens emergiram como fatores de risco para brucelose bovina no estado. A situação epidemiológica da brucelose bovina no Rio Grande do Sul manteve-se estável desde 2004, a despeito de boas coberturas vacinais terem sido registradas a partir de 2009. Assim, o estado deve continuar seu programa de vacinação, dando ênfase para a qualidade do processo e estimulando a utilização da vacina não indutora de anticorpos. Adicionalmente, o estado deve realizar um grande esforço de educação para que os produtores testem os animais de reprodução para brucelose antes de introduzi-los em sua...

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Effect of vaccination in lowering the prevalence of bovine brucellosis in the State of Mato Grosso, Brazil

Cited by 30 publications

References 17 publications

Mathematical modeling of bovine brucellosis control using the RB51 vaccine

Mathematical modeling of bovine brucellosis control using the RB51 vaccine

An update on the epidemiologic situation of bovine brucellosis in the State of Espírito Santo, Brazil

Epidemiological situation of bovine brucellosis after implementation of a vaccination program in Rio Grande do Sul State, Brazil

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