2000
DOI: 10.1016/s0264-410x(99)00444-2
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Effect of vaccination with 3 recombinant asexual-stage malaria antigens on initial growth rates of Plasmodium falciparum in non-immune volunteers

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Cited by 132 publications
(141 citation statements)
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“…However, the inhibition of merozoite invasion obtained with monoclonal antibodies has not been induced to date by immunisation. [36][37][38] Several other molecules are being channelled into human trials on the basis of results considered promising and obtained in one of the primate, mouse, or in-vitro models (figure 1). [39][40][41][42][43] Clinical trials will be essential to show whether these results can be extended to human beings.…”
Section: Personal Viewmentioning
confidence: 99%
“…However, the inhibition of merozoite invasion obtained with monoclonal antibodies has not been induced to date by immunisation. [36][37][38] Several other molecules are being channelled into human trials on the basis of results considered promising and obtained in one of the primate, mouse, or in-vitro models (figure 1). [39][40][41][42][43] Clinical trials will be essential to show whether these results can be extended to human beings.…”
Section: Personal Viewmentioning
confidence: 99%
“…ISA-720 has been evaluated with malaria antigens in several small-scale human clinical trials where the safety profiles were acceptable. [32][33][34] Saponins, such as QS-21 35 induce mixed immune responses with both antibody and cellular components. 36 QS-21 in combination with mono phosphoryl lipid A and an oil-in-water emulsion forms the proprietary adjuvant ASO2.…”
Section: Human Vaccines 19mentioning
confidence: 99%
“…However postthaw viability of the parasite stock varies widely (10-100%). This finding does not appear to be related to duration of storage, but may be caused by sensitivity of the parasites to freeze-thaw procedures and storage conditions, 9 and the current lack of an agreed or standardized viability assay.…”
Section: Controlled Human Blood Stage Malaria Infectionmentioning
confidence: 87%
“…4 Intravenous injection of a sterile suspension of thawed leukocyte-depleted erythrocytes, combined with monitoring of parasitemia postinoculation by highly-sensitive quantitative polymerase chain reaction (qPCR), enables accurate calculation of in vivo parasite multiplication rates (PMRs), a surrogate end-point for vaccine efficacy testing. 4,[6][7][8][9] The inoculum, estimated from the pre-freeze donor parasitemia, is retrospectively quantified by testing viability of the thawed stock. 4 Volunteers in BSP CHMIs were typically treated at a pre-defined parasite density predicted to prevent clinical malaria, 4,9,10 although more recent studies have used the onset of microscopic patency as a treatment endpoint.…”
Section: Controlled Human Blood Stage Malaria Infectionmentioning
confidence: 99%
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