1995
DOI: 10.1016/0264-410x(95)00119-l
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Effect of vaccination with a recombinant Bm86 antigen preparation on natural infestations of Boophilus microplus in grazing dairy and beef pure and cross-bred cattle in Brazil

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Cited by 86 publications
(36 citation statements)
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“…Tick resistance against vaccine antigens is less likely than resistance against chemical acaricides, because numerous different antibodies are usually generated against multiple antigen epitopes (Hajdusek et al, 2010). The demonstration that recombinant forms of the protein Bm86 confer protection against R. microplus infestations was a major achievement in parasite vaccinology, proving that a vaccine to protect against an ectoparasite is indeed a realistic possibility (Rand et al, 1989;Rodriguez et al, 1994Rodriguez et al, , 1995aRodriguez et al, , 1995b. Indeed, a Bm86-based tick vaccine was the first ectoparasite vaccine available in the market (Rodriguez et al, 1994).…”
Section: Discussionmentioning
confidence: 97%
“…Tick resistance against vaccine antigens is less likely than resistance against chemical acaricides, because numerous different antibodies are usually generated against multiple antigen epitopes (Hajdusek et al, 2010). The demonstration that recombinant forms of the protein Bm86 confer protection against R. microplus infestations was a major achievement in parasite vaccinology, proving that a vaccine to protect against an ectoparasite is indeed a realistic possibility (Rand et al, 1989;Rodriguez et al, 1994Rodriguez et al, , 1995aRodriguez et al, , 1995b. Indeed, a Bm86-based tick vaccine was the first ectoparasite vaccine available in the market (Rodriguez et al, 1994).…”
Section: Discussionmentioning
confidence: 97%
“…Commercialization of the vaccine against Rhipicephalus ( Boophilus ) microplus validated the feasibility of controlling ticks through immunization (Willadsen et al, 1995). Weaknesses of the R. microplus vaccine including effectiveness against one tick species (Rodriguez et al, 1995a, Rodriguez et al, 1995b, Garcia-Garcia et al, 2000), necessitates the search for effective target anti-tick vaccine antigens with potential to control multiple tick species (Mulenga et al, 2013a). …”
Section: Introductionmentioning
confidence: 99%
“…microplus vaccine products in other parts of the world. The level of efficacy reported for vaccines containing a recombinant form of Bm86 varies according to, among other factors, the expression system used for vaccine production, characteristics of the tick population targeted, and host factors (DE LA FUENTE et al, 1999;PATARROYO et al, 2002;RAND et al, 1989;RODRÍGUEZ et al, 1995;SITTE et al, 2002;ANDREOTTI et al, 2008;PARIZI et al, 2009). It has been postulated that sequence variation in the bm86 locus is associated with low susceptibility of certain R.…”
Section: Introductionmentioning
confidence: 99%