Effect of vaccination with an inactivated vaccine on transplacental transmission of BTV-8 in mid term pregnant ewes and heifers

Sluijs, M.T.W. van der; Schroer-Joosten, D.P.H.; Fid-Fourkour, A.; Vrijenhoek, Mieke P.; Debyser, Isolde; Gregg, Douglas A.; Dufe, Divine; Moulin, Véronique; Moormann, R.J.M.; Smit, A.J. de

doi:10.1016/j.vaccine.2011.10.106

Cited by 17 publications

(11 citation statements)

References 20 publications

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“…It was shown that, using immune globulins during pregnancy and after birth, some protective effect against some herpes viruses and HBV [98-100] was observed. Vaccines may also protect against mother-to-child transmission of infections [101]. Because the elimination of infection could minimize the risk of childhood cancer, everything possible should be done to prevent or control infections in both the mother and child.…”

Section: Discussionmentioning

confidence: 99%

Childhood cancers: what is a possible role of infectious agents?

Alibek

Mussabekova

Kakpenova

et al. 2013

Infect Agents Cancer

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The etiology of childhood cancers has been studied for more than 40 years. However, most if not all cancers occurring in children are attributed to unknown causes. This review is focused on the role of infections in cancer development and progression in children. The main infectious agents include human herpesviruses, polyoma viruses, and human papilloma viruses. It is known that infections can lead to carcinogenesis through various mechanisms, and most likely act in addition to genetic and environmental factors. Given the importance of the infectious etiology of childhood cancers, clinical implications and possible prevention strategies are discussed.

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Section: Discussionmentioning

confidence: 99%

Childhood cancers: what is a possible role of infectious agents?

Alibek

Mussabekova

Kakpenova

et al. 2013

Infect Agents Cancer

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“…Transplacental transmission of AHSV and related viruses has been described [21], [22], [23]. While traditional LAV for BTV and AHSV can block viremia and reduce transplacental transmission [24], [25], [26], the vaccines themselves are teratogenic. Although requiring confirmation with higher numbers, our study indicates that the replication-abortive vaccine strains maybe safe in pregnant ponies and maternal antibodies can be beneficially transferred to the foal.…”

Section: Discussionmentioning

confidence: 99%

Protective efficacy of multivalent replication-abortive vaccine strains in horses against African horse sickness virus challenge

Lulla

Losada

Lecollinet

et al. 2017

Vaccine

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“…Previous studies have indicated that transplacental transmission of BTV-8 wt has occurred in sheep [23,24] and cattle [20,35,36] but the frequency can be quite variable varying from 0-69% in sheep [21,24,25] and 20-35% in cattle [22,26,36]. This may depend, in part, on the time of infection in relation to the gestation period.…”

Section: Discussionmentioning

confidence: 99%

“…[19,20]). However, unexpectedly, following the introduction of the pathogenic BTV-8 into Northern Europe in 2006, it was observed that transplacental transmission of this virus strain occurred in both cattle and sheep [13,21-26]. A summary of the reported information on transplacental transmission of BTV in cattle and sheep has been published [27].…”

Section: Introductionmentioning

confidence: 99%

Transplacental transmission of field and rescued strains of BTV-2 and BTV-8 in experimentally infected sheep

Rasmussen

Savini

Lorusso

et al. 2013

Vet Res

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Transplacental transmission of bluetongue virus has been shown previously for the North European strain of serotype 8 (BTV-8) and for tissue culture or chicken egg-adapted vaccine strains but not for field strains of other serotypes. In this study, pregnant ewes (6 per group) were inoculated with either field or rescued strains of BTV-2 and BTV-8 in order to determine the ability of these viruses to cross the placental barrier. The field BTV-2 and BTV-8 strains was passaged once in Culicoides KC cells and once in mammalian cells. All virus inoculated sheep became infected and seroconverted against the different BTV strains used in this study. BTV RNA was detectable in the blood of all but two ewes for over 28 days but infectious virus could only be detected in the blood for a much shorter period. Interestingly, transplacental transmission of BTV-2 (both field and rescued strains) was demonstrated at high efficiency (6 out of 13 lambs born to BTV-2 infected ewes) while only 1 lamb of 12 born to BTV-8 infected ewes showed evidence of in utero infection. In addition, evidence for horizontal transmission of BTV-2 between ewes was observed. As expected, the parental BTV-2 and BTV-8 viruses and the viruses rescued by reverse genetics showed very similar properties to each other. This study showed, for the first time, that transplacental transmission of BTV-2, which had been minimally passaged in cell culture, can occur; hence such transmission might be more frequent than previously thought.

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Effect of vaccination with an inactivated vaccine on transplacental transmission of BTV-8 in mid term pregnant ewes and heifers

Cited by 17 publications

References 20 publications

Childhood cancers: what is a possible role of infectious agents?

Childhood cancers: what is a possible role of infectious agents?

Protective efficacy of multivalent replication-abortive vaccine strains in horses against African horse sickness virus challenge

Transplacental transmission of field and rescued strains of BTV-2 and BTV-8 in experimentally infected sheep

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