Effect of Vaccinium myrtillus anthocyanins on triiodothyronine transport into brain in the rat

Saija, Antonella; Princi, Pietro; D'Amico, N.; Pasquale, R. De; Costa, G

doi:10.1016/s1043-6618(09)80029-7

Cited by 19 publications

(11 citation statements)

References 3 publications

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“…T3 enters the brain by a specific transport in the capillaries; therefore, anthocyanins may mediate T3 transport at the capillary level. Bilberry-treated animals exhibited superior memory, better vision, and better control of sensory input [60,63].…”

Section: Neuroprotectionmentioning

confidence: 97%

Berry anthocyanins as novel antioxidants in human health and disease prevention

Zafra-Stone¹,

Yasmin

Bagchi³

et al. 2007

Molecular Nutrition Food Res

790

499

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Edible berries, a potential source of natural anthocyanin antioxidants, have demonstrated a broad spectrum of biomedical functions. These include cardiovascular disorders, advancing age-induced oxidative stress, inflammatory responses, and diverse degenerative diseases. Berry anthocyanins also improve neuronal and cognitive brain functions, ocular health as well as protect genomic DNA integrity. This chapter demonstrates the beneficial effects of wild blueberry, bilberry, cranberry, elderberry, raspberry seeds, and strawberry in human health and disease prevention. Furthermore, this chapter will discuss the pharmacological benefits of a novel combination of selected berry extracts known as OptiBerry, a combination of wild blueberry, wild bilberry, cranberry, elderberry, raspberry seeds, and strawberry, and its potential benefit over individual berries. Recent studies in our laboratories have demonstrated that OptiBerry exhibits high antioxidant efficacy as shown by its high oxygen radical absorbance capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic activities, and potential cytotoxicity towards Helicobacter pylori, a noxious pathogen responsible for various gastrointestinal disorders including duodenal ulcer and gastric cancer, as compared to individual berry extracts. OptiBerry also significantly inhibited basal MCP-1 and inducible NF-kappabeta transcriptions as well as the inflammatory biomarker IL-8, and significantly reduced the ability to form hemangioma and markedly decreased EOMA cell-induced tumor growth in an in vivo model. Overall, berry anthocyanins trigger genetic signaling in promoting human health and disease prevention.

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Section: Neuroprotectionmentioning

confidence: 97%

Berry anthocyanins as novel antioxidants in human health and disease prevention

Zafra-Stone¹,

Yasmin

Bagchi³

et al. 2007

Molecular Nutrition Food Res

790

499

View full text Add to dashboard Cite

show abstract

“…The rats were treated by gavage with ANT (30 and 100 mg/kg body weight) during this period (approximately 10 a.m.). The dose of ANT was chosen on the basis of protocols developed by our group (data not published) and previous studies that indicated neuroprotection [29,[49][50][51]. The control groups received only vehicle (2-ml/kg daily gavage of saline for 7 days).…”

Section: Treatmentmentioning

confidence: 99%

Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

Carvalho

Gutierres

Bohnert

et al. 2015

The Journal of Nutritional Biochemistry

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“…30 min after the training in inhibitory avoidance apparatus, as previously described (Ali and Arafa, 2011;Marisco et al, 2013); the second group of animals were submitted to same treatment and sacrificed 2 h post training, with seven animals per group (see Scheme 1). The dose of anthocyanins used was chosen on the basis of previous studies indicating neuroprotection (Gutierres et al, 2012b;Manach et al, 2004;Saija et al, 1990;Varadinova et al, 2009). In addition, the daily intake of anthocyanins in residents of the United States is estimated to be about 200 mg or about 9-fold higher than that of other dietary flavonoids, and this also served as a basis for this study (Manach et al, 2004;Wang and Stoner, 2008).…”

Section: Drug Administrationmentioning

confidence: 99%

Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine‐induced amnesia in rats

Gutierres

Carvalho

Schetinger

et al. 2013

Intl J of Devlp Neuroscience

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., Morsch, V.M., Spanevello, R., Mazzanti, C.M.,Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats, International Journal of Developmental Neuroscience (2013), http://dx.doi.org/10. 1016/j.ijdevneu.2013.12.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. animals were SCO injected (1mg/kg; IP) and were performed the behavior 58 tests, and submitted to euthanasia. A memory deficit was found in SCO group, 59but ANT treatment prevented this impairment of memory (P<0.05). The ANT 60 treatment per se had an anxiolitic effect. AChE activity was increased in both in 61 cortex and hipoccampus of SCO group, this effect was significantly attenuated 62 by ANT (P<0.05). SCO decreased Na + ,K + -ATPase and Ca 2+-ATPase activities 63 in hippocampus, and ANT was able to significantly (P<0.05) prevent these 64 effects. No significant alteration was found on NOx levels among the groups. In 65 conclusion, the ANT is able to regulate cholinergic neurotransmission and 66 restore the Na + ,K + -ATPase and Ca 2+ -ATPase activities, and also prevented 67 memory deficits caused by scopolamine administration. 68 69 70

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Effect of Vaccinium myrtillus anthocyanins on triiodothyronine transport into brain in the rat

Cited by 19 publications

References 3 publications

Berry anthocyanins as novel antioxidants in human health and disease prevention

Berry anthocyanins as novel antioxidants in human health and disease prevention

Anthocyanins suppress the secretion of proinflammatory mediators and oxidative stress, and restore ion pump activities in demyelination

Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine‐induced amnesia in rats

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