2016
DOI: 10.18203/2320-1770.ijrcog20160884
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Effect of vaginal pH on efficacy of dinoprostone gel for labour induction

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Cited by 7 publications
(6 citation statements)
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“…No significant difference was found in our study with respect to time taken to enter the active phase of labour in the two groups. Similar findings had been reported by U. Singh et al ,[ 9 ] Kurian et al ,[ 10 ] Ramsey et al ,[ 5 ] and Onen et al . [ 11 ] However, in studies conducted by Goswami et al ,[ 8 ] Aruna et al ,[ 7 ] and Yayla Abide et al ,[ 12 ] a significant difference was reported between the two groups; that is, this duration was significantly shorter in the high-pH group than the low-pH group.…”
Section: Discussionsupporting
confidence: 91%
“…No significant difference was found in our study with respect to time taken to enter the active phase of labour in the two groups. Similar findings had been reported by U. Singh et al ,[ 9 ] Kurian et al ,[ 10 ] Ramsey et al ,[ 5 ] and Onen et al . [ 11 ] However, in studies conducted by Goswami et al ,[ 8 ] Aruna et al ,[ 7 ] and Yayla Abide et al ,[ 12 ] a significant difference was reported between the two groups; that is, this duration was significantly shorter in the high-pH group than the low-pH group.…”
Section: Discussionsupporting
confidence: 91%
“…Concerning this, a few researches have explored the effect of pH on drug performance. For instance, the effect of the vaginal pH over the induction of labor with misoprostol and dinoprostone was studied by Chandra et al [81] and by Kurian et al [82], respectively. No effect was observed when misoprostol was employed (pKa = 14.68), while the pH was a positive factor for the effectiveness of dinoprostone (pKa = 4.9).…”
Section: Possible Effects Of Changes In Vaginal Microbiota On Drugmentioning
confidence: 99%
“…30 Other studies reported the benefits of high vaginal pH in improving prostaglandin effectiveness in reducing the duration of the active phase of labor. 10 31 Moreover, Kurian et al 32 stated women with multiple parities were more likely to have a higher vaginal pH, leading to an increase in dinoprostone gel efficacy causing higher Bishop's scores and more normal vaginal deliveries compared with those with lower vaginal pH. On the contrary, Chandra et al 33 demonstrated that vaginal pH has no effect in reducing labor duration among women undergoing labor induction with vaginal prostaglandin as well as the optimal pH in the vagina for reaching the maximal prostaglandin efficacy has not yet been detected.…”
Section: Discussionmentioning
confidence: 99%