Effect of Vagotomy on Gastric Mucosal Blood Flow

Bell, P. R. F.; Battersby, Cameron

doi:10.1016/s0016-5085(68)80123-4

Cited by 42 publications

(13 citation statements)

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“…Some investigators have examined the effects of vagotomy topromote healing of AGML [8,30]. Bell et al [2] reported that vagotomy controlled the output of gastric juice and promoted healing of AGML. Delaney [8], however, reported just the opposite, i.e., only the gastric antrum had a significantly different perfusion rate in both vagotomized and vagally innervated dogs.…”

Section: Discussionmentioning

confidence: 99%

“…He concluded that vagal resection had no long-term effect on gastrointestinal ischemia. Bell and Battersby [2] also reported contradictory results for vagotomy with respect to its healing effect on AGML and stated that vagotomy produced a significant decrease in gastric mucosal blood flow, which continued for at least 2 h. Bell and Shelly [3] emphasized the necessity of measuring mucosal blood flow in conscious animals. They reported that vagotomy had no long-term effect on the ability of gastric mucosal vasculature to respond to vasoactive agents.…”

Section: Discussionmentioning

confidence: 99%

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The role of neostigmine in development of acute gastric mucosal lesion in dogs with live bacterial flora-induced shock

et al. 1990

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The factors that frequently cause the development of acute gastric mucosal lesions (AGML) were studied in 37 mongrel dogs. Bacterial shock was induced by bolus injection of E. coli live bacterial flora (10(10) cells/kg body weight) under parietal cell-stimulated condition by intravenous administration of 0.008 mg/kg per hour of pentagastrin. In addition, 0.01 mg/kg per hour of neostigmine sulfate was administered intravenously during the experiment. Frequent development of AGML was observed in the neostigmine-administered canines without significant changes in the gastric corporal and antral tissue blood flow. In the neostigmine-administered group, AGML was observed in the antrum, although in the other group AGML was mostly observed in the corpus. These results suggest that a neostigmine-induced systemic vagostimulated condition by intravenous administration of neostigmine plays an important role in the development of AGML in dogs subjected to bacterial shock.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of neostigmine in development of acute gastric mucosal lesion in dogs with live bacterial flora-induced shock

et al. 1990

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“…Mucosal capillaries of the rat stomach are known to be regulated directly by the parasympathetic nervous system (Nakamura et al 1982). The increase in gastric blood flow has been demonstrated during vagal stimulation, and the blood flow has been contrarily reduced by vagotomy as well as by sympathetic stimulation in dogs (Peter et al 1963;Bell and Battersby 1968). Transient ischemia due to mucosal capillary constriction is the most probable cause of degeneration observed in parietal cells as well as chief cells in the early stage after truncal vagotomy in dogs, although it does not account for the longstanding reduction of gastric acid secretion (Halaris 1971) and there is an argument against the reduction of blood flow from the results of the radiorubidium distribution technique (Delaney 1967).…”

Section: Discussionmentioning

confidence: 99%

Quantitative light and electron microscopical studies of the effect of vagotomy on parietal cells in rats.

Nakamura

1985

Tohoku J. Exp. Med.

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As early as 3 days after truncal vagotomy, a decrease in the number of parietal cells per gland and the length of fundic glands of the stomach was observed in young Wistar rats. A decrease in the size of cells and the number of mitochondria per cell was also evident in the remaining parietal cells. These atrophic changes lasted nearly one month after the operation. A decrease in the cellular size and mitochondrial number in parietal cells was noted again in the rats sacrificed 12 months after the operation. Since the similar changes were also seen in the age-matched controls, the changes in older rats were interpreted as an aging phenomenon.

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“…Flow rates can be estimated from the rate of washout of radioactive isotopes of inert gases ( 133 Xenon, 85krypton) introduced into tissue intravascularly (14,15). Flow rates can be estimated from the rate of washout of radioactive isotopes of inert gases ( 133 Xenon, 85krypton) introduced into tissue intravascularly (14,15).…”

Section: Techniques Measuring Mucosal Blood Flow (Mbf)mentioning

confidence: 99%

Gastric Blood Flow and Acid Secretion: Problems of the Methodology and Regulatory Mechanisms

Döbrönte

Várró²

1998

Scandinavian Journal of Gastroenterology

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Döbrönte Z, Varró V. Gastric blood flow and acid secretion. Problems of the methodology and regulatory mechanisms. Scand J Gastroenterol 1998;33 Suppl 228:21-30. Methods for proper measurement of gastric mucosal blood flow (MBF) in animal experiments or in clinical studies are critically reviewed. It can be stated that none of the techniques hitherto published fulfil all the criteria for proper measurement of the mucosal blood flow and concomitant acid production in the stomach. Some give an estimate of local blood flow changes (e.g. H 2 gas clearance, laser Doppler flowmetry) in man without the possibility of simultaneous acid measurement. The 99m Tc-MAP clearance technique developed by the authors reflects changes in both parameters and may also be used in clinical studies, when limitations of the method are taken into consideration. As a rule we assume that acid production and mucosal blood flow may change independently. The effects of various bioactive substances and drugs on both parameters are analysed. It seems that many contradictory findings have arisen because of differences in technique and experimental animals used.

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Effect of Vagotomy on Gastric Mucosal Blood Flow

Cited by 42 publications

References 9 publications

The role of neostigmine in development of acute gastric mucosal lesion in dogs with live bacterial flora-induced shock

The role of neostigmine in development of acute gastric mucosal lesion in dogs with live bacterial flora-induced shock

Quantitative light and electron microscopical studies of the effect of vagotomy on parietal cells in rats.

Gastric Blood Flow and Acid Secretion: Problems of the Methodology and Regulatory Mechanisms

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