Effect of valproic acid combined with transplantation of olfactory ensheathing cells modified by neurotrophic 3 gene on nerve protection and repair after traumatic brain injury

Li, Haiming; Yin, Zhijie; Yue, Shuangzhu; An, Yunying; Wang, Xiaoyin; Zhou, Shifang; Meng, Lei; Jin, Baozhe

doi:10.1016/j.npep.2023.102389

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…The distinctive properties of OECs arise from their phagocytic abilities combined with their low production of pro-inflammatory cytokines [67]. Notably, while OEC transplantation has shown to be safe in several clinical trials [68] and has garnered attention in the context of spinal cord injury, its application for TBI treatment remains limited to a few studies [69,70]. jury, differentiate into neuronal-like cells, and improve the histological and behavioral outcomes [58][59][60].…”

Section: Therapeutic Potential Of Exogenous Cellsmentioning

confidence: 99%

Cell-Based Therapies for the Treatment of Traumatic Brain Injury: Promises and Trajectories

Habashy,

Omais,

Haupt

et al. 2024

Biologics

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Traumatic Brain Injury (TBI) is a debilitating condition that poses a significant public health concern. Historically linked to motor vehicle accidents, the epidemiology of TBI has evolved. Falls now emerge as the predominant cause, particularly among older adults. Sport-related TBIs have also garnered increased attention due to concerns regarding long-term neurological sequelae. To date, therapeutic interventions remain limited and have yet to yield substantial clinical benefits. Cell-based therapies offer promising avenues for neural repair and regeneration: endogenous stem cell therapies capitalize on endogenous pools that can be triggered by the injury and further enhanced by therapeutic approaches. In contrast, exogenous cell therapies provide an exogenous source of cells. However, challenges such as age-related decline in neurogenesis, age-related inflammation, and the heterogeneity of TBI present significant hurdles to overcome. Moreover, translating stem cell research from the laboratory to clinical applications necessitates the adherence to good manufacturing practice standards, which presents distinct obstacles. Addressing these challenges requires a multifaceted approach, including careful patient selection in clinical trials, appropriate experimental models, and the optimization of therapeutic techniques. Ultimately, a combination of strategies is likely to yield the most promising outcomes in the pursuit of effective TBI therapies.

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Section: Therapeutic Potential Of Exogenous Cellsmentioning

confidence: 99%

Cell-Based Therapies for the Treatment of Traumatic Brain Injury: Promises and Trajectories

Habashy,

Omais,

Haupt

et al. 2024

Biologics

View full text Add to dashboard Cite

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Electromagnetic-responsive targeted delivery scaffold technology has better potential to repair injured peripheral nerves: a narrative review

Chen,

Xu,

Ramakrishna

2024

Advanced Technology in Neuroscience

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Peripheral nerve injury with long size defects has been an urgent clinical challenge. With the development of bioengineering, nanotechnology and additive manufacturing technologies, biologic delivery systems have gradually shown great potential for the treatment of peripheral nerve injury. The main problem of general biologic delivery systems is that the loading capacity of biologics is positively correlated with the release rate, and it is more difficult to achieve long-term stable release of high biologics-loaded scaffolds; thus, it is not possible to carry out full-cycle targeted therapy for peripheral nerve injury sites. To solve these problems, the mechanisms of common neurotrophic factors, bioelectrical signals and biomagnetic signals for repairing peripheral nerve injury are discussed in this paper. Moreover, this review summarizes the mechanism of electroactive and magnetoresponsive materials that have significant ability to repair peripheral nerve injury to promote nerve regeneration and provides an overview of the biologic delivery mechanism for repairing peripheral nerve injury in different structural dimensions. It was finally concluded that electromagnetic responsive targeted delivery scaffolds (four-dimensional scaffolds) have good peripheral nerve repair ability, which provides guidance for the clinical application of targeted therapy for peripheral nerve injury.

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Effect of valproic acid combined with transplantation of olfactory ensheathing cells modified by neurotrophic 3 gene on nerve protection and repair after traumatic brain injury

Cited by 2 publications

References 39 publications

Cell-Based Therapies for the Treatment of Traumatic Brain Injury: Promises and Trajectories

Cell-Based Therapies for the Treatment of Traumatic Brain Injury: Promises and Trajectories

Electromagnetic-responsive targeted delivery scaffold technology has better potential to repair injured peripheral nerves: a narrative review

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