Effect of Vanadium on Metabolism of Glucose in the Rat

Meeks, Marion J.; Landolt, Robert R.; Kessler, Wayne V.; Born, Gordon S.

doi:10.1002/jps.2600600336

Cited by 20 publications

(6 citation statements)

References 6 publications

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“…The significant level of 5% (p<0.05) was used as the minimum acceptable probability for the difference between the means. Vanadium is one nutritional trace element that has been found to be very effective in reducing blood glucose [17]. It is known to act as a potent insulin mimetic agent by increasing glucose transport and metabolism in skeletal muscle, liver, and adipose tissue [2,18].…”

Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Grifola frondosa Rich in Vanadium

Cui

Han

Jing-ran

et al. 2009

Biol Trace Elem Res

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The hypoglycemic activity of fermented mushroom of Grifola frondosa rich in vanadium (GFRV) was studied in this paper. Alloxan- and adrenalin-induced hyperglycemic mice were used in the study. The blood glucose and the HbA1c of the mice were analyzed respectively. After the mice were administered (ig) with GFRV, the blood glucose and the HbA1c of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01) and ascension of blood glucose induced by adrenalin was inhibited (p < 0.01). Also, the bodyweight of the alloxan-induced hyperglycemic mice was increased gradually. In the fermented mushroom of G. frondosa, vanadium at lower doses in combination with G. frondosa induced significant decreases of the blood glucose and HbA1c levels in hyperglycemic mice.

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Section: Resultsmentioning

confidence: 99%

Hypoglycemic Activity of Grifola frondosa Rich in Vanadium

Cui

Han

Jing-ran

et al. 2009

Biol Trace Elem Res

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“…Meeks et al [26] reported the effect of vanadium on metabolism of glucose in rats. Thompson et al [27] studied the effect of vanadium (V) intake on blood glucose lowering using streptozotocin (STZ)-diabetic rats.…”

Section: Article In Pressmentioning

confidence: 98%

Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium

Han

Yuan

Wang³

et al. 2006

Journal of Trace Elements in Medicine and Biology

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“…Glucose metabolism is also affected by vanadium. Orally administered ammonium metavanadate reduced 14C-glucose catabolism as measured by 14C02 expiration (Meeks et al, 1971). In vitro studies using rat apidocytes as target cells demonstrated that vanadium stimulates glucose transport and oxidation as well as hepatic glycogen synthesis (Tolman et al, 1979;Dubyak and Kleinzeller, 1980;Shechter and Karlish, 1980).…”

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confidence: 99%

Sodium orthovanadate stimulation of DNA synthesis in nakano mouse lens epithelial cells in serum‐free medium

Jones

Reid

1984

Journal Cellular Physiology

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Quiescent cultured Nakano mouse lens cells incubated for 40 hours with sodium orthovanadate incorporated 3H-thymidine at an accelerated rate; the greatest response occurred at 20 microM vanadate, whereas by 2 microM an incorporation rate equivalent to unstimulated cells was noted. Microscopic examination of the cells revealed that those exposed to concentrations of vanadate greater than 100 microM had lysed by the end of the 40-hour incubation. Reduction in vanadate exposure time to 1 hour caused the cells to incorporate the greatest amount of 3H-thymidine at a vanadate concentration of 200 microM to 500 microM. Half-maximum incorporation of 3H-thymidine (after a 40-hour incubation) was induced by a 2-hour incubation with 20 microM vanadate. Studies with insulin showed that while 20 ng/ml insulin alone did not increase 3H-thymidine incorporation, 20 ng/ml insulin in combination with 20 microM vanadate resulted in a significant increase in 3H-thymidine uptake over cells exposed to only vanadate. Insulin alone will increase cell number and insulin with vanadate are synergistic in the stimulation of DNA synthesis, but the two together show no further increase in cell number over that produced by insulin alone. Thus, vanadate can increase progression from G1/G0 to S-phase, but cannot stimulate cells to divide. Studies designed to detect DNA damage and repair rather than S-phase DNA synthesis demonstrated that vanadate was not causing increased 3H-thymidine uptake by damaging DNA. Cell counts revealed that vanadate, while able to induce DNA synthesis, does not induce mitosis. Autoradiography and equilibrium sedimentation experiments demonstrated that gene amplification was not occurring. A known vanadate exchange inhibitor blocked the ability of vanadate to increase 3H-thymidine incorporation which is consistent with the idea that cellular internalization of vanadate is required for this effect to be seen. 86Rb+ uptake experiments demonstrate that the vanadate concentration inducing 50% inhibition of (Na+, K+)ATPase is nearly two orders of magnitude more concentrated that vanadate concentrations shown capable of inducing 3H-thymidine uptake. This strongly suggests that (Na+, K+)ATPase inhibition is not the central mechanism by which DNA synthesis is stimulated by vanadate.

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Effect of Vanadium on Metabolism of Glucose in the Rat

Cited by 20 publications

References 6 publications

Hypoglycemic Activity of Grifola frondosa Rich in Vanadium

Hypoglycemic Activity of Grifola frondosa Rich in Vanadium

Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium

Sodium orthovanadate stimulation of DNA synthesis in nakano mouse lens epithelial cells in serum‐free medium

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