This study investigates the impact of Inconel 625 interlayer on dissimilar welded low nickel austenitic stainless steel (LNiASS) and super duplex stainless steel (S32760) using activated tungsten inert gas (ATIG) welding. Two weldments were prepared: with and without (autogenous) interlayer. Geometrical investigation of the weld cross sections revealed that interlayer-based welding significantly increased the depth of penetration and decreased weld width as compared to autogenous welding at the same welding current. The dual microstructure was observed in the weld zone (WZ) of autogenous weldment while a fully austenitic structure with few intermetallics was observed in the WZ of interlayer-based weldment. Mechanical properties, particularly impact strength observed to be improved in the case of interlayer-based weldment (91±2 J) compared to autogenous weldment (68±2 J). Lower microhardness was noticed for the WZ of interlayer-based weldment (258±3 HV0.2) than WZ of autogenous (279±2 HV0.2) weldment due to the presence of higher content of Ni. However, the ultimate tensile strength of interlayer-based weldment (654 MPa), falls short in comparison to the autogenous weldment (693 MPa), indicating a compromised joint efficiency of 5.96%. The corrosion resistance was observed to be higher for the WZ of interlayer-based weldment attributed to the higher content of Ni and Mo. The sensitization study revealed a 47.33% degree of sensitization in the WZ of autogenous weldments due to dual microstructure, while interlayer-based weldments showed no sensitization.