Effect of Various Catechins on the IL-12p40 Production by Murine Peritoneal Macrophages and a Macrophage Cell Line, J774.1

The Effect of Epigallocatechin Gallate on Lipopolysaccharide-Induced Acute Lung Injury in a Murine Model

“…Another report showed that EGCG had various effects on phosphorylation of mitogen activated protein kinases (MAPKs). Recently, Yun, et al showed that EGCG inhibited TNF-α induced phosphorylation of MAPKs family, such as ERK1/2, p38 and JNK in synovial fibroblast [28], while others showed that EGCG inhibited LPS-induced activation of p38, but augmented phosphorylation of ERK1/2 in macrophage cell line, J774.1 cells [29]. Taken together, the effects of EGCG on the inflammatory cytokine production and MAPKs phosphorylation are thought to be cell type-dependent.…”

Anti-Inflammatory Role of Natural Polyphenols and Their Degradation Products

“…Also, EGCG attenuated the production of TNF-and MIP-2, and the phosphorylation of ERK1/2 and JNK in the lungs of mice administered with LPS intratracheally (Bae et al, 2010). Recently, Yun, et al showed that EGCG inhibited TNF-induced phosphorylation of MAPKs family, such as ERK1/2, p38 and JNK in synovial fibroblast (Yun et al, 2008), while others showed that EGCG inhibited LPS-induced activation of p38, but augmented phosphorylation of ERK1/2 in J774.1 macrophage cells (Ichikawa et al, 2004). Inhibition of protein tyrosine kinase activity, reducing c-jun mRNA expression and inhibition of JNK1 activation by EGCG were reported by Yokozawa et al (Yokozawa & Dong, 1997).…”

Role of tea catechins in prevention of aging and age-related disorders

“…They may achieve this by inhibition of COX-1/COX-2 enzymes (Seeram et al, 2003;Santangelo et al, 2007), repression of nitric oxide (NO) production (Lyu and Park, 2005;Santangelo et al, 2007), varying degrees of regulation of the expression of proinflammatory cytokines like IL-6 and IL-12 (Ichikawa et al, 2004;Santangelo et al, 2007) or by the inhibition of nuclear factor kappa B (NF-κB) and Activator Protein-1 (AP-1) mediated gene activation (Ichikawa et al, 2004;Ahmad et al, 2000;Zaveri, 2006). Catechins inhibit the activation of genes in response to ROS; for example, in the case of NF-κB by either scavenging ROS or by reducing the degradation of the IκB, the inhibitory protein for NF-κB (Nam et al, 2001;Ichikawa et al, 2004;Zaveri, 2006).…”

“…Catechins inhibit the activation of genes in response to ROS; for example, in the case of NF-κB by either scavenging ROS or by reducing the degradation of the IκB, the inhibitory protein for NF-κB (Nam et al, 2001;Ichikawa et al, 2004;Zaveri, 2006). As chronic inflammation occurs only when the normal inflammatory response of the body is disturbed, it may be a common link between chronic disorders.…”