Effect of various modes of tracheal mechanical stimulation on the cough motor pattern

Veternik, Marcel; Simera, Michal; Martvon, Lukas; Cibulkova, Lucia; Kotmanova, Zuzana; Poliacek, Ivan

doi:10.1016/j.resp.2024.104367

Respiratory Physiology & Neurobiology

2025

DOI: 10.1016/j.resp.2024.104367

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Effect of various modes of tracheal mechanical stimulation on the cough motor pattern

Marcel Veternik,

Michal Simera,

Lukas Martvon

et al.

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2025

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Peripheral antitussives affect temporal features of tracheobronchial coughing in cats

Poliacek,

Veterník,

Martvon

et al. 2025

Journal of Applied Physiology

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The influence of peripheral antitussive drugs on spatiotemporal features of coughing have not been reported. We hypothesized that this class of compounds would alter the cough motor pattern, in part, by lengthening cough phases. Peripherally acting antitussives 3-Aminopropylphosphinic Acid (3APPi, 5mg/kg) and levodropropizine (Levo, 3mg/kg) were injected i.v. in anesthetized spontaneously breathing cats (13 males, 2 females; 4.38 ± 0.19 kg). Spatio-temporal analysis of cough induced by mechanical stimulation of the trachea showed significant reductions in cough number and expiratory cough efforts after administration of each drug. A significant reduction in inspiratory cough efforts occurred after Levo. Both drugs induced temporal changes in the cough motor pattern, including prolongations of inspiratory phase, inspiratory-expiratory transition, total cough diaphragm activity and total cough cycle duration. Levo also significantly lengthened the expiratory phase of cough. A shortening of the overlap between diaphragm and abdominal activity and cough abdominal EMG activity was observed after the administration of 3APPi. No significant changes in cardiorespiratory data were seen, with the exception of prolonged expiratory phase after 3APPi and lower blood pressure after Levo. Peripherally induced cough suppression is accompanied with changes in cough temporal characteristics that are not observed after administration of centrally acting antitussives. The motor output produced by the cough central pattern generator differs significantly when coughing is perturbed by peripherally and centrally acting antitussives.

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Peripheral antitussives affect temporal features of tracheobronchial coughing in cats

Poliacek,

Veterník,

Martvon

et al. 2025

Journal of Applied Physiology

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Effect of various modes of tracheal mechanical stimulation on the cough motor pattern

Cited by 1 publication

References 47 publications

Peripheral antitussives affect temporal features of tracheobronchial coughing in cats

Peripheral antitussives affect temporal features of tracheobronchial coughing in cats

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