Effect of Various Mushroom Preparations on Cholesterol Levels in Rats

Kaneda, Takashi; Tokuda, Setsuko

doi:10.1093/jn/90.4.371

Cited by 73 publications

(25 citation statements)

References 4 publications

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“…Initial research on the cholesterol-lowering effects of mushrooms was conducted in Japan in the 1960s, and it was demonstrated that when rats were fed with a highfat and high-cholesterol diet supplemented with 5% water of the fruiting bodies of L. edodes for ten weeks, the plasma cholesterol levels of the animals decreased significantly (Sun et al, 1984). The adenosine derivative lentinacin or lentysine (currently known as eritadenine [2(R), 3(R)-dihydroxy-4-(9-adenyl)-butyric acid] (12) was subsequently isolated and identified to be one of the active hypocholesterolemic components in the shiitake mushroom (Kaneda & Tokuda, 1966).…”

Section: Mushrooms As Hypocholesterolemic Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

124

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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Section: Mushrooms As Hypocholesterolemic Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

124

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“…Their results clearly showed that the cultured broth had an anti-hepatitis B virus activity in vitro and protected mice from liver damage in vivo. On the other hand, different studies reported the relationship between low plasma cholesterol levels and mushrooms consumption [67][68][69][70]. In animal experiments, Kabir et al [71] investigated the dietary effect of G. lucidum on blood pressure and their results showed a significant reduction of the plasma cholesterol level in animals fed with G. lucidum, and these observations have been reported previously.…”

Section: Mechanisms Of Action Of G Lucidum Polysaccharides and Terpenmentioning

confidence: 62%

Ganoderma lucidum Polysaccharides and Terpenoids: Profile and Health Benefits

Benkeblia¹

2016

J Food Nutri Diete

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Recent studies have shown that mushrooms are recognized as a promising source of functional and nutraceutical compounds. The species Ganoderma lucidum (also called Reishi or Lingzhi) is a mushroom used in medicine because Chinese attributes to this fungus better health and longevity. Among the numerous bioactive compounds identified in G. lucidum are polysaccharides mostly β-glucans, heteropolysaccharides or glycoproteins, terpenoids mostly ganoderic acids and derivatives, as well as many other bioactive proteinases that contribute to health and diseases prevention. The aim of this review is to report on the profile of the most bioactive compounds, particularly polysaccharides and terpenoids of G. lucidum.

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“…Eritadenine from L. edodes mushroom has a wide range of eŠects on lipid metabolism such as a hypocholesterolemic action, 1) an increase in liver microsomal PE concentration, 4,5) a decrease in D6-desaturase activity, 6,7) and an alteration of the fatty acid and molecular species proˆles of liver and plas- 1 Each value, which was estimated according to the method shown in Fig. 5, represents the time required for a half-change during 5 days after changing from the control diet to the eritadenine-supplemented (50 mg W kg) diet.…”

Section: Discussionmentioning

confidence: 99%

“…1) A compound currently called eritadenine [2(R ), 3(R )-dihydroxy-4-(9-adenyl)-bytyric acid] has been isolated as a hypocholesterolemic factor of this mushroom. 2,3) In addition to the hypocholesterolemic action, eritadenine was found to decrease both the phosphatidylcholine (PC) W phosphatidylethanolamine (PE) ratio 4,5) and D6-desaturase activity 6,7) in the liver microsomes of rats.…”

mentioning

confidence: 99%