Effect of various therapeutic approaches on plasma potassium and major regulating factors in terminal renal failure

Blumberg, A; Weidmann, P; Shaw, Sidney; Gnädinger, Markus

doi:10.1016/s0002-9343(88)80086-x

Cited by 207 publications

(133 citation statements)

References 35 publications

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“…This is particularly based on the results of studies in dogs with experimentally induced hyperkalemia24 and human patients with end‐stage renal disease25, 26 where alkalinization after intravenous administration of sodium bicarbonate was reported to be ineffective in lowering blood K + concentrations. However, it was discussed that the plasma potassium‐lowering effect of sodium bicarbonate depends on the presence of a metabolic acidosis and more importantly on the degree of intracellular acidosis 22.…”

Section: Discussionmentioning

confidence: 99%

Effects of Alkalinization and Rehydration on Plasma Potassium Concentrations in Neonatal Calves with Diarrhea

Trefz

Lorch

Zitzl

et al. 2015

Veterinary Internal Medicne

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BackgroundIncreased plasma potassium concentrations (K+) in neonatal calves with diarrhea are associated with acidemia and severe clinical dehydration and are therefore usually corrected by intravenous administration of fluids containing sodium bicarbonate.ObjectivesTo identify clinical and laboratory variables that are associated with changes of plasma K+ during the course of treatment and to document the plasma potassium‐lowering effect of hypertonic (8.4%) sodium bicarbonate solutions.AnimalsSeventy‐one neonatal diarrheic calves.MethodsProspective cohort study. Calves were treated according to a clinical protocol using an oral electrolyte solution and commercially available packages of 8.4% sodium bicarbonate (250–750 mmol), 0.9% saline (5–10 L), and 40% dextrose (0.5 L) infusion solutions.ResultsInfusions with 8.4% sodium bicarbonate solutions in an amount of 250–750 mmol had an immediate and sustained plasma potassium‐lowering effect. One hour after the end of such infusions or the start of a sodium bicarbonate containing constant drip infusion, changes of plasma K+ were most closely correlated to changes of venous blood pH, plasma sodium concentrations and plasma volume (r = −0.73, −0.57, −0.53; P < .001). Changes of plasma K+ during the subsequent 23 hours were associated with changes of venous blood pH, clinical hydration status (enophthalmos) and serum creatinine concentrations (r = −0.71, 0.63, 0.62; P < .001).Conclusions and Clinical ImportanceThis study emphasizes the importance of alkalinization and the correction of dehydration in the treatment of hyperkalemia in neonatal calves with diarrhea.

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Section: Discussionmentioning

confidence: 99%

Effects of Alkalinization and Rehydration on Plasma Potassium Concentrations in Neonatal Calves with Diarrhea

Trefz

Lorch

Zitzl

et al. 2015

Veterinary Internal Medicne

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“…Although sodium bicarbonate use has fallen out of favour in patients on dialysis, it should be considered in patients with significant acidaemia where it is expected that infusion of bicarbonate would increase serum pH significantly. 13 Cation exchange resin mixed with sorbitol should be used orally if hyperkalaemia is not life threatening, however resin mixed with water (and not sorbitol) can be repeated hourly for rapid removal of potassium. It should be remembered that each gram of sodium polystyrene resin (Kayexalate) removes 0.5-1.0 mmol of potassium in exchange for 2-3 mmol of sodium.…”

Section: Management Of Hyperkalaemiamentioning

confidence: 99%

Hypokalaemia and hyperkalaemia

Rastergar

Soleimani

2001

Postgrad Med J

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Disturbances in potassium homoeostasis presenting as low or high serum potassium are common, especially among hospitalised patients. Given the fact that untreated hypokalaemia or hyperkalaemia is associated with high morbidity and mortality, it is critical to recognise and treat these disorders promptly. In this article, normal potassium homoeostasis is reviewed initially and then a pathophysiological approach to work-up and management of hypokalaemia and hyperkalaemia is presented. Recent advances with respect to the role of kidney in handling of the potassium, the regulation of renal ion transporters in hypokalaemia, and treatment of hypokalaemia and hyperkalaemia will be discussed. (Postgrad Med J 2001;77:759-764)

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“…The increase in potassium elimination by the body can be attained by the administration of diuretics, exchange enzymes (Kayexalate) and renal replacement therapy. 37 …”

Section: Hyperkalemiamentioning

confidence: 99%

Suporte de terapia intensiva no paciente oncológico

Sapolnik¹

2003

J. Pediatr. (Rio J.)

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Objective: To review the most important aspects of the clinical presentation and treatment of children with cancer in intensive care units. Medline (1970Medline ( to 2003; search terms: children, cancer, oncology, intensive care, complications. General and pediatric oncology textbooks. Sources of data: Summary of the findings:Practically all organs may be affected by cancer or by its treatment. The main complications include infections, hematological problems and electrolyte/ metabolic disturbances. Intensive care therapy is necessary to correct organic dysfunctions (cardiovascular, respiratory, renal, gastrointestinal, and neurologic). Nutritional and emotional support, as well as pain control are fundamental aspects for recovery in children. The intensivist should be alert to interrupt intensive care measures if required. Conclusions:Many studies show that the use of intensive care therapy in children with cancer is not futile, with a reduction in mortality and improvement in the quality of life of these children in the medium and long terms.

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Effect of various therapeutic approaches on plasma potassium and major regulating factors in terminal renal failure

Cited by 207 publications

References 35 publications

Effects of Alkalinization and Rehydration on Plasma Potassium Concentrations in Neonatal Calves with Diarrhea

Effects of Alkalinization and Rehydration on Plasma Potassium Concentrations in Neonatal Calves with Diarrhea

Hypokalaemia and hyperkalaemia

Suporte de terapia intensiva no paciente oncológico

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