Effect of vascular endothelial growth factor on hepatic regenerative activity following partial hepatectomy in rats

Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats

“…40 We have previously demonstrated a stimulatory effect of exogenous VEGF-165 and VEGF-121 on liver regeneration following PHx. 41,42 We have also documented a gain of heparanase expression following 70% PHx. 15 HF treatment, which was used in our animal model to reduce collagen deposition, 20 elevated VEGF-165 expression and also stimulated heparanase expression.…”

Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells

“…7,8 In response to liver injury, VEGF may enhance the regenerative potential of residual hepatocytes and that of nonparenchymal cells. 7,8 We have previously shown that the nonparenchymal hepatic cell, the hepatic stellate cell, expresses receptors for VEGF: Flt-1 and Flk-1. 9 This observation suggests that stellate cells are also cellular targets for VEGF during hepatic wound healing and carcinogenesis.…”

LYVE1 and PROX1 in the reconstruction of hepatic sinusoids after partial hepatectomy in mice

“…The intra-platelet VEGFA level was elevated during liver regeneration in hepatocellular carcinoma patients who underwent partial hepatectomy [2]. In a rat study, the exogenous administration of VEGF at the early stage after partial hepatectomy improved liver regeneration [3]. These data suggest that VEGFA may have an essential role in mediating vasculogenesis during the early stage of liver regeneration.…”