Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis

Abstract

Abstract. Pharyngitis presents as an inflammation of the oropharynx, and clinical examination often shows evidence of nasopharyngitis. In numerous cases the condition occurs as a self-limiting illness of non-infectious aetiology, whose clinical management remains a matter for debate given the inappropriateness of antibiotics, the reported worsening following steroid use and the recent discouragement of the use of Chinese herbal medicine. The aim of the present study was thus to test VBC-1814/7J, a poly-phytocompound with known anti-inflammatory and immune-response enhancing properties, in an experimental model of non-infectious pharyngitis. Experimental non-infectious pharyngitis was induced by applying a pyridine solution to the surface of the pharyngeal mucosa in rats that were either normally fed (group A) or fed VBC-1814/7J three days prior to and three days subsequent to the induction of pharyngitis (group B). Healthy rats treated with topical saline were used as a control (group C). At time-points of 0, one hour, one day and three days sacrifices were carried out and microscopic examination, Evans blue (EB) dye extravasation and tissue concentrations of tumour necrosis factor (TNF)-α, interleukin (IL)-6 and mRNA of α-and β-defensins were studied. As compared with group C, group A showed significant microscopic damage, EB extravasation, and increases in the levels of TNF-α and IL-6, as well as in the mRNA of three defensins (P<0.001) on the third day of observation. VBC-1814/7J significantly mitigated these microscopic and inflammatory markers while allowing a prompter and wider defensin reaction (P<0.05 vs. group A). These data suggest that VBC-1814/7J, as demonstrated in earlier studies, has the potential to address non-infectious pharyngitis in clinical practice.

Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozyme-based Therapy in Patients with Noninfectious Sore Throat

“…In this model, microscopic changes as well as increased levels of tumor necrosis factor alpha (TNF-α), interleukin -6 (IL-6) and expression of defensins' genes were observed. Those changes could be mitigated by application of phytochemical preparations with immunomodulatory and anti-inflammatory activities (7,8). Non-infectious sore throat was investigated in clinical settings as well, when pharynx was exposed to cold dry air and acute response characteristic for non-infectious sore throat was provoked.…”

Application of High-Performance Liquid Chromatography Coupled with Linear Ion Trap Quadrupole Orbitrap Mass Spectrometry for Qualitative and Quantitative Assessment of Shejin-Liyan Granule Supplements

“…Patients often report pain and irritation in the throat. In certain cases, the illness is not caused by an infection; in such a setting, antibiotics may be the wrong choice for treatment or they may only offer a modest improvement in symptoms [ 1 , 2 ]. Traditional Chinese medicines have been successfully used to treat pharyngitis for thousands of years because of their variety of multi-target, therapeutic, and synergistic effects [ 1 , 3 , 4 ].…”

Lysozyme in the treatment of non-infectious sore throat

“…Inflammation is the pathophysiological mechanism of both infectious and non-infectious sore throat, so similar anti-inflammatory therapies have beneficial effects in both etiologies [2]. Few studies showed positive effects of non-steroidal anti-inflammatory medicines, paracetamol, and steroids [13]. Various herbal formulations and antiseptic lozenges, sprays, and mouthwashes (with or without the addition of an anesthetic or analgesic) are most commonly used [2,12].…”