Effect of Venous Stasis on Vessel Wall Fibrinolysis

Abstract

SummaryThe effects of prolonged venous stasis on release of plasminogen activators (PA) from the caval vein of rats were studied.PA activity was continuously reduced in the intimal layer and after 8 hr of stasis the reduction was statistically significant. After 2 and 3 days no intimal PA activity was found. The PA activity in the adventitial vasa vasorum was unchanged during the experimental period.

Vein wall re-endothelialization after deep vein thrombosis is improved with low-molecular-weight heparin

“…Thus, persistence of thrombus, which occurs in this stasis model, may negate the early beneficial effect of LMWH. 36 Preservation of the endothelium paralleled preservation of the VSMC layer (␣-SMA area) and was observed with prethrombosis, and to a lesser extent, post-thrombosis LMWH treatment at 4 days. The ␣-SMA antigen is also a marker for VSMC contractible phenotype, which is the physiological vasculae state.…”

Venous stasis-induced fibrinolysis prevents thrombosis in mice: role of α2-antiplasmin

“…6,11,12 Prolonged venous stasis has been associated with early reductions in plasminogen activator activity. 13 Expression of tissue-type plasminogen activator (tPA) and urinary-type plasminogen activator (uPA) relative to their inhibitor, plasminogen activator inhibitor-1 (PAI-1), is very low in experimental venous thrombi in the first week and increases marginally through 14 days. 14 Evidence suggests that uPA contributes to the resolution of acute and chronic venous thrombi, 15,16 but little is known about the role of the fibrinolytic system in the stages of early thrombus formation.…”