2000
DOI: 10.1136/heart.83.3.262
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Effect of verapamil on systolic and diastolic coronary blood flow velocity in asymptomatic and mildly symptomatic patients with hypertrophic cardiomyopathy

Abstract: Objective-To assess non-invasively the eVect of verapamil treatment on coronary blood flow velocity in asymptomatic and mildly symptomatic patients with hypertrophic cardiomyopathy. Design-High frequency transthoracic Doppler echocardiography was used to compare resting phasic coronary blood flow velocity before and after a one month period of verapamil treatment in 17 patients (14 men and three women) with non-obstructive hypertrophic cardiomyopathy. Eighteen healthy subjects formed an age and sex matched con… Show more

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Cited by 22 publications
(13 citation statements)
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“…In these studies CFR was measured using adenosine (standard vasodilator to test endothelium-independent vasodilatation). In patients with hypertrophic cardiomyopathy additionally the vasomotor response to stressors testing endothelium-dependent vasomotion was studied [18-22,47]. Cold pressor test [20,21], handgrip [22,47] and pacing [19] was used as stressing stimuli.…”
Section: Reviewmentioning
confidence: 99%
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“…In these studies CFR was measured using adenosine (standard vasodilator to test endothelium-independent vasodilatation). In patients with hypertrophic cardiomyopathy additionally the vasomotor response to stressors testing endothelium-dependent vasomotion was studied [18-22,47]. Cold pressor test [20,21], handgrip [22,47] and pacing [19] was used as stressing stimuli.…”
Section: Reviewmentioning
confidence: 99%
“…In patients with hypertrophic cardiomyopathy additionally the vasomotor response to stressors testing endothelium-dependent vasomotion was studied [18-22,47]. Cold pressor test [20,21], handgrip [22,47] and pacing [19] was used as stressing stimuli. Importantly, the noninvasive approach provides an opportunity to assess asymptomatic patients [18,20] and to recruit healthy subjects to form adequate control groups [13,18,19,21,22], which is impossible in an invasive study.…”
Section: Reviewmentioning
confidence: 99%
See 1 more Smart Citation
“…Previous studies have demonstrated that coronary vasomotor responses to the sympathetic activation induced by mental stress or cold pressor testing correlate closely with vasomotor responses to acetylcholine [35,40], suggesting that a coronary vasodilator response to sympathetic activation reflects the functional integrity of the endothelium [41]. More recently, these stressors have tested with non-invasive PET [42,43] and with transthoracic Doppler echocardiography [44]. However, one drawback with these adrenergic stressors is that an impaired efferent adrenergic system [45] and concurrent adrenergic modulating therapies such as adrenergic blockers may alter the coronary flow responses.…”
Section: Measurement Of Coronary Endothelium-dependent Vasomotor Funcmentioning
confidence: 97%
“…Determination of coronary flow measurements employing coronary vasodilators provides important information on coronary flow reserve and the predominantly vascular smooth muscle control. With respect to endothelial-dependent vasodilation, adrenergically mediated flow responses to cold pressor testing and hand-grip [35,40] have been tested using non-invasive PET measured myocardial blood flow [42,43] and transthoracic Doppler echocardiography [44]. It has been argued that any research study aiming to fully assess the global parameter and integrated function of coronary circulation may require the measurement of both coronary flow reserve and endothelium-dependent vasodilation.…”
Section: Utility Of Coronary Flow Measurement In Researchmentioning
confidence: 99%