Effect of Virgin Coconut Oil from Green Coconut on High-Density Lipoprotein (HDL) Levels in Blood Serum of White Mice

Abstract

This study aims to determine the effect of High-Density Lipoprotein (VCO) dose on mice's blood serum High-Density Lipoprotein (HDL) levels. This study is an experimental study using 24 mice divided into four groups. Control (-), Control (+) were fed egg yolks 0.025 mL/g body weight, Dose 0.02 and Dose 0.025 were experimental groups, given egg yolks 0.025 mL/g mice body weight and VCO at a dose of 0.020 mL, and 0.025 mL/g body weight of mice. HDL levels were determined on days 7, 14, and 21 by enzymatic method using 20 D* spectrophotometry. The statistical test found that the length of time giving VCO significantly affected blood serum HDL levels in mice with Fcount > Ftable (Fcount = 7.128 and Ftable = 5.14). In contrast, variations in VCO dose did not significantly affect blood serum HDL levels. mice with Fcount < Ftable (Fcount = 3.33 and Ftable = 4.76). The highest HDL level was at a dose of 0.020 mL/g body weight of mice with a treatment period of 14 days, namely 164,033 mg/dL of blood.

Virgin Coconut Oil: A Dietary Intervention for Dyslipidaemia in Patients with Diabetes Mellitus

“…As a result, the bonding process of cholesterol esters–lipoprotein cores improves; thus, low-density lipoprotein (VLDL) catabolism increases. The process means that free cholesterol and phospholipids resulting from VLDL breakdown are transferred to HDLs; thereby, HDL formation increases [ 34 ].…”

“…In relation to ABI improvement, VCO reduces LDL levels by dissolving cholesterol. Thus, blood circulation becomes smooth, maintaining the ABI value [ 34 ]. The evidence is similar to our finding that the VCO group experienced refinement of the ABI value, whereas the control group experienced worsening of the ABI value.…”